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Periocular basal cell carcinoma: 5-year outcome following Slow Mohs surgery with formalin-fixed paraffin-embedded sections and delayed closure.
Br J Ophthalmol. 2009 Apr; 93(4):474-6.BJ

Abstract

AIM

The aim of the study was to determine the 5-year outcome of periocular basal cell carcinoma (BCC) managed by Mohs surgery using formalin-fixed, paraffin-embedded sections (Slow Mohs).

METHODS

This was a prospective, non-comparative, interventional case series of all patients with periocular BCC treated by Slow Mohs in Newcastle upon Tyne, UK, between 1985 and 1999. Data collected included demographic information, indication for Slow Mohs, tumour site, histology, recurrence rate after 5 years and cosmetic outcome.

RESULTS

Of 287 BCCs in 278 patients, 5-year follow-up data were available for 173 (60.2%). Recurrence following Slow Mohs occurred in one patient: 0.34% of total and 0.58% of those with 5-year follow-up. The main indication for Slow Mohs was most frequently due to the tumour site. Cosmetic outcome was deemed excellent in 56%, good in 18%, adequate in 8%, unknown in 14% and revision advised in only 4%.

CONCLUSION

The low 5-year recurrence rate (0.58%) reported in this prospective series confirms the importance of margin-controlled removal of recurrent, poorly defined or critically sited BCCs, and illustrates that Slow Mohs is equivalent to standard Mohs. While delayed closure does not appear to compromise cosmetic outcome, this technique offers a histologically superior and cheaper alternative to frozen-section Mohs surgery.

Authors+Show Affiliations

Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK. dsm@doctors.org.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

19060015

Citation

Morris, D S., et al. "Periocular Basal Cell Carcinoma: 5-year Outcome Following Slow Mohs Surgery With Formalin-fixed Paraffin-embedded Sections and Delayed Closure." The British Journal of Ophthalmology, vol. 93, no. 4, 2009, pp. 474-6.
Morris DS, Elzaridi E, Clarke L, et al. Periocular basal cell carcinoma: 5-year outcome following Slow Mohs surgery with formalin-fixed paraffin-embedded sections and delayed closure. Br J Ophthalmol. 2009;93(4):474-6.
Morris, D. S., Elzaridi, E., Clarke, L., Dickinson, A. J., & Lawrence, C. M. (2009). Periocular basal cell carcinoma: 5-year outcome following Slow Mohs surgery with formalin-fixed paraffin-embedded sections and delayed closure. The British Journal of Ophthalmology, 93(4), 474-6. https://doi.org/10.1136/bjo.2008.141325
Morris DS, et al. Periocular Basal Cell Carcinoma: 5-year Outcome Following Slow Mohs Surgery With Formalin-fixed Paraffin-embedded Sections and Delayed Closure. Br J Ophthalmol. 2009;93(4):474-6. PubMed PMID: 19060015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periocular basal cell carcinoma: 5-year outcome following Slow Mohs surgery with formalin-fixed paraffin-embedded sections and delayed closure. AU - Morris,D S, AU - Elzaridi,E, AU - Clarke,L, AU - Dickinson,A J, AU - Lawrence,C M, Y1 - 2008/12/05/ PY - 2008/12/9/pubmed PY - 2009/4/29/medline PY - 2008/12/9/entrez SP - 474 EP - 6 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 93 IS - 4 N2 - AIM: The aim of the study was to determine the 5-year outcome of periocular basal cell carcinoma (BCC) managed by Mohs surgery using formalin-fixed, paraffin-embedded sections (Slow Mohs). METHODS: This was a prospective, non-comparative, interventional case series of all patients with periocular BCC treated by Slow Mohs in Newcastle upon Tyne, UK, between 1985 and 1999. Data collected included demographic information, indication for Slow Mohs, tumour site, histology, recurrence rate after 5 years and cosmetic outcome. RESULTS: Of 287 BCCs in 278 patients, 5-year follow-up data were available for 173 (60.2%). Recurrence following Slow Mohs occurred in one patient: 0.34% of total and 0.58% of those with 5-year follow-up. The main indication for Slow Mohs was most frequently due to the tumour site. Cosmetic outcome was deemed excellent in 56%, good in 18%, adequate in 8%, unknown in 14% and revision advised in only 4%. CONCLUSION: The low 5-year recurrence rate (0.58%) reported in this prospective series confirms the importance of margin-controlled removal of recurrent, poorly defined or critically sited BCCs, and illustrates that Slow Mohs is equivalent to standard Mohs. While delayed closure does not appear to compromise cosmetic outcome, this technique offers a histologically superior and cheaper alternative to frozen-section Mohs surgery. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/19060015/Periocular_basal_cell_carcinoma:_5_year_outcome_following_Slow_Mohs_surgery_with_formalin_fixed_paraffin_embedded_sections_and_delayed_closure_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=19060015 DB - PRIME DP - Unbound Medicine ER -