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Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea.
Am J Clin Oncol. 2008 Dec; 31(6):580-4.AJ

Abstract

OBJECTIVE

Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID).

METHODS

We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test.

RESULTS

Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID.

CONCLUSIONS

Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID.

Authors+Show Affiliations

Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic. bohuslav.melichar@fnol.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19060591

Citation

Melichar, Bohuslav, et al. "Intestinal Permeability and Vitamin a Absorption in Patients With Chemotherapy-induced Diarrhea." American Journal of Clinical Oncology, vol. 31, no. 6, 2008, pp. 580-4.
Melichar B, Dvorák J, Krcmová L, et al. Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. Am J Clin Oncol. 2008;31(6):580-4.
Melichar, B., Dvorák, J., Krcmová, L., Hyspler, R., Urbánek, L., & Solichová, D. (2008). Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. American Journal of Clinical Oncology, 31(6), 580-4. https://doi.org/10.1097/COC.0b013e318174dbb9
Melichar B, et al. Intestinal Permeability and Vitamin a Absorption in Patients With Chemotherapy-induced Diarrhea. Am J Clin Oncol. 2008;31(6):580-4. PubMed PMID: 19060591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea. AU - Melichar,Bohuslav, AU - Dvorák,Josef, AU - Krcmová,Lenka, AU - Hyspler,Radomír, AU - Urbánek,Lubor, AU - Solichová,Dagmar, PY - 2008/12/9/pubmed PY - 2009/1/14/medline PY - 2008/12/9/entrez SP - 580 EP - 4 JF - American journal of clinical oncology JO - Am. J. Clin. Oncol. VL - 31 IS - 6 N2 - OBJECTIVE: Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID). METHODS: We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test. RESULTS: Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID. CONCLUSIONS: Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID. SN - 1537-453X UR - https://www.unboundmedicine.com/medline/citation/19060591/Intestinal_permeability_and_vitamin_A_absorption_in_patients_with_chemotherapy_induced_diarrhea_ L2 - http://dx.doi.org/10.1097/COC.0b013e318174dbb9 DB - PRIME DP - Unbound Medicine ER -