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Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties.
J Nat Prod. 2008 Dec; 71(12):2068-72.JN

Abstract

Six new unusual C-4'-prenylated flavonols, dorsilurins F-K (1-6), together with six known compounds were isolated from the roots of Dorstenia psilurus, and their structures were elucidated on the basis of spectroscopic evidence. The isolated compounds exhibited moderate to low alpha-glucosidase inhibitory activity. Dorsilurin F (1), with three unmodified prenyl groups, was the most active, while dorsilurin K (6), with only one unmodified prenyl group, was the least active compound. Furthermore, NMR data of dorsilurin C (7), isolated some years ago from the same plant, have been revised.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tabopda TK
Organic Chemistry Department, University of Yaoundé I, P.O. Box 8664, Yaoundé, Cameroon. ttabopda@yahoo.fr
Ngoupayo J
No affiliation info available
Awoussong PK
No affiliation info available
Mitaine-Offer AC
No affiliation info available
Ali MS
No affiliation info available
Ngadjui BT
No affiliation info available
Lacaille-Dubois MA
No affiliation info available

MeSH

CameroonFlavonoidsGlycoside Hydrolase InhibitorsMolecular StructureMoraceaeNuclear Magnetic Resonance, BiomolecularPlant RootsPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19061390

Citation

Tabopda, Turibio K., et al. "Triprenylated Flavonoids From Dorstenia Psilurus and Their Alpha-glucosidase Inhibition Properties." Journal of Natural Products, vol. 71, no. 12, 2008, pp. 2068-72.
Tabopda TK, Ngoupayo J, Awoussong PK, et al. Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties. J Nat Prod. 2008;71(12):2068-72.
Tabopda, T. K., Ngoupayo, J., Awoussong, P. K., Mitaine-Offer, A. C., Ali, M. S., Ngadjui, B. T., & Lacaille-Dubois, M. A. (2008). Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties. Journal of Natural Products, 71(12), 2068-72. https://doi.org/10.1021/np800509u
Tabopda TK, et al. Triprenylated Flavonoids From Dorstenia Psilurus and Their Alpha-glucosidase Inhibition Properties. J Nat Prod. 2008;71(12):2068-72. PubMed PMID: 19061390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties. AU - Tabopda,Turibio K, AU - Ngoupayo,Joseph, AU - Awoussong,Patrice K, AU - Mitaine-Offer,Anne-Claire, AU - Ali,Muhammad S, AU - Ngadjui,Bonaventure T, AU - Lacaille-Dubois,Marie-Aleth, PY - 2008/12/9/pubmed PY - 2009/1/29/medline PY - 2008/12/9/entrez SP - 2068 EP - 72 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 12 N2 - Six new unusual C-4'-prenylated flavonols, dorsilurins F-K (1-6), together with six known compounds were isolated from the roots of Dorstenia psilurus, and their structures were elucidated on the basis of spectroscopic evidence. The isolated compounds exhibited moderate to low alpha-glucosidase inhibitory activity. Dorsilurin F (1), with three unmodified prenyl groups, was the most active, while dorsilurin K (6), with only one unmodified prenyl group, was the least active compound. Furthermore, NMR data of dorsilurin C (7), isolated some years ago from the same plant, have been revised. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/19061390/Triprenylated_flavonoids_from_Dorstenia_psilurus_and_their_alpha_glucosidase_inhibition_properties_ L2 - https://doi.org/10.1021/np800509u DB - PRIME DP - Unbound Medicine ER -