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Estimation of anti-inflammatory, antinociceptive and antioxidant activities of Arctium minus (Hill) Bernh. ssp. minus.
J Ethnopharmacol. 2009 Jan 21; 121(2):318-23.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Arctium minus (Hill) Bernh. ssp. minus (Asteraceae) leaves are used to alleviate rheumatic pain, against fever and sunstroke with externally application in Turkish folk medicine.

AIM OF THE STUDY

To evaluate the anti-inflammatory, antinociceptive and antioxidant activities of aqueous and ethanol extracts prepared from the leaves of Arctium minus ssp. minus.

MATERIALS AND METHODS

The ethanolic and aqueous extracts from the leaves of Arctium minus ssp. minus were evaluated in mice for anti-inflammatory activity using carrageenan-induced hind paw edema model and for antinociceptive activity using p-benzoquinone-induced abdominal contractions test. Moreover, the antioxidant power of the extracts has been determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and flow injection analysis-luminol chemiluminescence (FIA-CL). In addition, the total phenolic content in both extracts was determined with spectrophotometric method.

RESULTS

Our results showed that only the ethanol extract exhibited a dose-dependent anti-inflammatory activity ranging between 11.1 and 23.6% at 200mg/kg dose as well as displayed a significant antinociceptive activity without inducing any gastric damage. Although, both extracts were shown to possess significant DPPH radical-scavenging activity, that of aqueous extract was found to have more pronounced activity. In FIA-CL system, the ethanol extract was shown to possess a significant scavenger activity against H(2)O(2) while the aqueous extract was much more potent antioxidant activity against HOCl-luminol CL than ethanol extract.

CONCLUSION

According to our results, it was concluded that Arctium minus ssp. minus contains potent natural antioxidants. In this study, in vivo experimental results have also supported the folk medicinal utilization of Arctium minus ssp. minus.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330 Ankara, Turkey. nurgun@gazi.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19061945

Citation

Erdemoglu, Nurgun, et al. "Estimation of Anti-inflammatory, Antinociceptive and Antioxidant Activities of Arctium Minus (Hill) Bernh. Ssp. Minus." Journal of Ethnopharmacology, vol. 121, no. 2, 2009, pp. 318-23.
Erdemoglu N, Turan NN, Akkol EK, et al. Estimation of anti-inflammatory, antinociceptive and antioxidant activities of Arctium minus (Hill) Bernh. ssp. minus. J Ethnopharmacol. 2009;121(2):318-23.
Erdemoglu, N., Turan, N. N., Akkol, E. K., Sener, B., & Abacioglu, N. (2009). Estimation of anti-inflammatory, antinociceptive and antioxidant activities of Arctium minus (Hill) Bernh. ssp. minus. Journal of Ethnopharmacology, 121(2), 318-23. https://doi.org/10.1016/j.jep.2008.11.009
Erdemoglu N, et al. Estimation of Anti-inflammatory, Antinociceptive and Antioxidant Activities of Arctium Minus (Hill) Bernh. Ssp. Minus. J Ethnopharmacol. 2009 Jan 21;121(2):318-23. PubMed PMID: 19061945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of anti-inflammatory, antinociceptive and antioxidant activities of Arctium minus (Hill) Bernh. ssp. minus. AU - Erdemoglu,Nurgun, AU - Turan,Nilufer N, AU - Akkol,Esra Küpeli, AU - Sener,Bilge, AU - Abacioglu,Nurettin, Y1 - 2008/11/17/ PY - 2008/03/17/received PY - 2008/11/03/revised PY - 2008/11/06/accepted PY - 2008/12/9/pubmed PY - 2009/4/2/medline PY - 2008/12/9/entrez SP - 318 EP - 23 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 121 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Arctium minus (Hill) Bernh. ssp. minus (Asteraceae) leaves are used to alleviate rheumatic pain, against fever and sunstroke with externally application in Turkish folk medicine. AIM OF THE STUDY: To evaluate the anti-inflammatory, antinociceptive and antioxidant activities of aqueous and ethanol extracts prepared from the leaves of Arctium minus ssp. minus. MATERIALS AND METHODS: The ethanolic and aqueous extracts from the leaves of Arctium minus ssp. minus were evaluated in mice for anti-inflammatory activity using carrageenan-induced hind paw edema model and for antinociceptive activity using p-benzoquinone-induced abdominal contractions test. Moreover, the antioxidant power of the extracts has been determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and flow injection analysis-luminol chemiluminescence (FIA-CL). In addition, the total phenolic content in both extracts was determined with spectrophotometric method. RESULTS: Our results showed that only the ethanol extract exhibited a dose-dependent anti-inflammatory activity ranging between 11.1 and 23.6% at 200mg/kg dose as well as displayed a significant antinociceptive activity without inducing any gastric damage. Although, both extracts were shown to possess significant DPPH radical-scavenging activity, that of aqueous extract was found to have more pronounced activity. In FIA-CL system, the ethanol extract was shown to possess a significant scavenger activity against H(2)O(2) while the aqueous extract was much more potent antioxidant activity against HOCl-luminol CL than ethanol extract. CONCLUSION: According to our results, it was concluded that Arctium minus ssp. minus contains potent natural antioxidants. In this study, in vivo experimental results have also supported the folk medicinal utilization of Arctium minus ssp. minus. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/19061945/Estimation_of_anti_inflammatory_antinociceptive_and_antioxidant_activities_of_Arctium_minus__Hill__Bernh__ssp__minus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00640-5 DB - PRIME DP - Unbound Medicine ER -