Tags

Type your tag names separated by a space and hit enter

Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats.
J Ethnopharmacol. 2009 Jan 30; 121(3):419-24.JE

Abstract

AIM OF THE STUDY

Nigella sativa L. (Ranunculaceae) seeds have been used traditionally for centuries, notably for treating diabetes.

MATERIALS AND METHODS

We studied the effects of the crude aqueous extract of Nigella sativa seeds on intestinal glucose absorption in vitro using a short-circuit current technique and in vivo using an oral glucose tolerance test.

RESULTS

The aqueous extract of Nigella sativa (0.1 pg/ml to 100 ng/ml) exerted dose-dependent inhibition of sodium-dependent glucose transport across isolated rat jejunum. Maximal inhibition exceeded 80% and IC50 was close to 10 pg/ml. An oral glucose tolerance test was carried out in rats after the initial dose and after a 6-week treatment of Nigella sativa (2 g/(kg day)), and compared to metformin (300 mg/(kg day)). Chronic Nigella sativa treatment improved glucose tolerance as efficiently as metformin. Nigella sativa and metformin also reduced body weight without any toxic effect.

CONCLUSIONS

To our knowledge, this is the first demonstration that Nigella sativa directly inhibits the electrogenic intestinal absorption of glucose in vitro. Together with the observed improvement of glucose tolerance and body weight in rats after chronic oral administration in vivo, these effects further validate the traditional use of Nigella sativa seeds against diabetes.

Authors+Show Affiliations

Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Université Mohammed V-Souissi, Rabat, Morocco.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19061948

Citation

Meddah, Bouchra, et al. "Nigella Sativa Inhibits Intestinal Glucose Absorption and Improves Glucose Tolerance in Rats." Journal of Ethnopharmacology, vol. 121, no. 3, 2009, pp. 419-24.
Meddah B, Ducroc R, El Abbes Faouzi M, et al. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol. 2009;121(3):419-24.
Meddah, B., Ducroc, R., El Abbes Faouzi, M., Eto, B., Mahraoui, L., Benhaddou-Andaloussi, A., Martineau, L. C., Cherrah, Y., & Haddad, P. S. (2009). Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. Journal of Ethnopharmacology, 121(3), 419-24. https://doi.org/10.1016/j.jep.2008.10.040
Meddah B, et al. Nigella Sativa Inhibits Intestinal Glucose Absorption and Improves Glucose Tolerance in Rats. J Ethnopharmacol. 2009 Jan 30;121(3):419-24. PubMed PMID: 19061948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. AU - Meddah,Bouchra, AU - Ducroc,Robert, AU - El Abbes Faouzi,Moulay, AU - Eto,Bruno, AU - Mahraoui,Lahcen, AU - Benhaddou-Andaloussi,Ali, AU - Martineau,Louis Charles, AU - Cherrah,Yahia, AU - Haddad,Pierre Selim, Y1 - 2008/11/17/ PY - 2008/05/14/received PY - 2008/10/13/revised PY - 2008/10/25/accepted PY - 2008/12/9/pubmed PY - 2009/6/10/medline PY - 2008/12/9/entrez SP - 419 EP - 24 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 121 IS - 3 N2 - AIM OF THE STUDY: Nigella sativa L. (Ranunculaceae) seeds have been used traditionally for centuries, notably for treating diabetes. MATERIALS AND METHODS: We studied the effects of the crude aqueous extract of Nigella sativa seeds on intestinal glucose absorption in vitro using a short-circuit current technique and in vivo using an oral glucose tolerance test. RESULTS: The aqueous extract of Nigella sativa (0.1 pg/ml to 100 ng/ml) exerted dose-dependent inhibition of sodium-dependent glucose transport across isolated rat jejunum. Maximal inhibition exceeded 80% and IC50 was close to 10 pg/ml. An oral glucose tolerance test was carried out in rats after the initial dose and after a 6-week treatment of Nigella sativa (2 g/(kg day)), and compared to metformin (300 mg/(kg day)). Chronic Nigella sativa treatment improved glucose tolerance as efficiently as metformin. Nigella sativa and metformin also reduced body weight without any toxic effect. CONCLUSIONS: To our knowledge, this is the first demonstration that Nigella sativa directly inhibits the electrogenic intestinal absorption of glucose in vitro. Together with the observed improvement of glucose tolerance and body weight in rats after chronic oral administration in vivo, these effects further validate the traditional use of Nigella sativa seeds against diabetes. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19061948/Nigella_sativa_inhibits_intestinal_glucose_absorption_and_improves_glucose_tolerance_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00594-1 DB - PRIME DP - Unbound Medicine ER -