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Quercetin regulates Th1/Th2 balance in a murine model of asthma.
Int Immunopharmacol 2009; 9(3):261-7II

Abstract

Quercetin is found to be the most active of the flavonoids in studies and many medicinal plants owe much of their activity to their high Quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. However, its anti-allergic effect in the Th1/Th2 immune response was poorly understood. Recently, it was shown that T-bet and GATA-3 were master Th1 and Th2 regulatory transcription factors. In this study, we have attempted to determine whether Quercetin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in OVA-induced asthma model mice. Quercetin reduced the increased levels of IL-4, Th2 cytokine production in OVA-sensitized and -challenged mice. The other side, it increased IFN-gamma, Th1 cytokine production in Quercetin administrated mice. We also examined to ascertain whether Quercetin could influence Eosinophil peroxidase (EPO) activity. The administration of Quercetin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that Quercetin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of Quercetin in terms of its effects in a murine model of asthma, and also broaden current perspectives in our understanding of the immunopharmacological functions of Quercetin.

Authors+Show Affiliations

Department of Pediatrics, Pusan National University College of Medicine, Busan 602-739, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19061976

Citation

Park, Hee-ju, et al. "Quercetin Regulates Th1/Th2 Balance in a Murine Model of Asthma." International Immunopharmacology, vol. 9, no. 3, 2009, pp. 261-7.
Park HJ, Lee CM, Jung ID, et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol. 2009;9(3):261-7.
Park, H. J., Lee, C. M., Jung, I. D., Lee, J. S., Jeong, Y. I., Chang, J. H., ... Park, Y. M. (2009). Quercetin regulates Th1/Th2 balance in a murine model of asthma. International Immunopharmacology, 9(3), pp. 261-7. doi:10.1016/j.intimp.2008.10.021.
Park HJ, et al. Quercetin Regulates Th1/Th2 Balance in a Murine Model of Asthma. Int Immunopharmacol. 2009;9(3):261-7. PubMed PMID: 19061976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quercetin regulates Th1/Th2 balance in a murine model of asthma. AU - Park,Hee-ju, AU - Lee,Chang-Min, AU - Jung,In Duk, AU - Lee,Jun Sik, AU - Jeong,Young-il, AU - Chang,Jeong Hyun, AU - Chun,Sung-Hak, AU - Kim,Min-Jae, AU - Choi,Il-Whan, AU - Ahn,Soon-Cheol, AU - Shin,Yong Kyoo, AU - Yeom,Seok-Ran, AU - Park,Yeong-Min, Y1 - 2008/12/04/ PY - 2008/09/10/received PY - 2008/10/13/revised PY - 2008/10/17/accepted PY - 2008/12/9/pubmed PY - 2009/5/1/medline PY - 2008/12/9/entrez SP - 261 EP - 7 JF - International immunopharmacology JO - Int. Immunopharmacol. VL - 9 IS - 3 N2 - Quercetin is found to be the most active of the flavonoids in studies and many medicinal plants owe much of their activity to their high Quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. However, its anti-allergic effect in the Th1/Th2 immune response was poorly understood. Recently, it was shown that T-bet and GATA-3 were master Th1 and Th2 regulatory transcription factors. In this study, we have attempted to determine whether Quercetin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in OVA-induced asthma model mice. Quercetin reduced the increased levels of IL-4, Th2 cytokine production in OVA-sensitized and -challenged mice. The other side, it increased IFN-gamma, Th1 cytokine production in Quercetin administrated mice. We also examined to ascertain whether Quercetin could influence Eosinophil peroxidase (EPO) activity. The administration of Quercetin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that Quercetin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of Quercetin in terms of its effects in a murine model of asthma, and also broaden current perspectives in our understanding of the immunopharmacological functions of Quercetin. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/19061976/Quercetin_regulates_Th1/Th2_balance_in_a_murine_model_of_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(08)00325-1 DB - PRIME DP - Unbound Medicine ER -