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Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.
Carbohydr Res. 2009 Sep 28; 344(14):1788-91.CR

Abstract

In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. The anti-adhesive properties of MCP as well as its potential for increasing apoptotic responses of tumor cells to chemotherapy by inhibiting galectin-3 anti-apoptotic function are discussed in the light of a potential use of this carbohydrate-based substance in the treatment of multiple human malignancies.

Links

Publisher Full Text
ncbi.nlm.nih.gov
linkinghub.elsevier.com
PMC Free PDF

Authors+Show Affiliations

Glinsky VV
Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA.
Raz A
No affiliation info available

MeSH

AnimalsAnoikisAntineoplastic Agents, PhytogenicApoptosisCitrusGalectin 3HumansNeoplasm InvasivenessNeoplasm MetastasisNeovascularization, PathologicPectinsPlant Extracts

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19061992

Clinical Trial Links

Effect of Modified Citrus Pectin on PSA Kinetics in Biochemical Relapsed PC With Serial Increases in PSA

Citation

Glinsky, Vladislav V., and Avraham Raz. "Modified Citrus Pectin Anti-metastatic Properties: One Bullet, Multiple Targets." Carbohydrate Research, vol. 344, no. 14, 2009, pp. 1788-91.
Glinsky VV, Raz A. Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydr Res. 2009;344(14):1788-91.
Glinsky, V. V., & Raz, A. (2009). Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydrate Research, 344(14), 1788-91. https://doi.org/10.1016/j.carres.2008.08.038
Glinsky VV, Raz A. Modified Citrus Pectin Anti-metastatic Properties: One Bullet, Multiple Targets. Carbohydr Res. 2009 Sep 28;344(14):1788-91. PubMed PMID: 19061992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. AU - Glinsky,Vladislav V, AU - Raz,Avraham, Y1 - 2008/09/26/ PY - 2008/07/31/received PY - 2008/08/19/accepted PY - 2008/12/9/pubmed PY - 2009/12/18/medline PY - 2008/12/9/entrez SP - 1788 EP - 91 JF - Carbohydrate research JO - Carbohydr Res VL - 344 IS - 14 N2 - In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. The anti-adhesive properties of MCP as well as its potential for increasing apoptotic responses of tumor cells to chemotherapy by inhibiting galectin-3 anti-apoptotic function are discussed in the light of a potential use of this carbohydrate-based substance in the treatment of multiple human malignancies. SN - 1873-426X UR - https://www.unboundmedicine.com/medline/citation/19061992/Modified_citrus_pectin_anti_metastatic_properties:_one_bullet_multiple_targets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-6215(08)00410-2 DB - PRIME DP - Unbound Medicine ER -