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TRP channels as emerging targets for pain therapeutics.
Expert Opin Ther Targets. 2009 Jan; 13(1):69-81.EO

Abstract

BACKGROUND

The transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest for the development of potential pain therapeutics.

OBJECTIVE/METHODS

We review the advances in the field in recent years, focusing on a rationale for pain therapy and potential challenges associated with these targets.

RESULTS/CONCLUSIONS

Vanilloid-type TRP 1 (TRPV1) is the most well studied and advanced member of the family, with selective agonists and antagonists already in clinical use or development, respectively. Among other thermo-TRPs (including TRPV2 - 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel pain targets.

Authors+Show Affiliations

Eli Lilly and Company, Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, UK. broad_lisa@lilly.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19063707

Citation

Broad, Lisa M., et al. "TRP Channels as Emerging Targets for Pain Therapeutics." Expert Opinion On Therapeutic Targets, vol. 13, no. 1, 2009, pp. 69-81.
Broad LM, Mogg AJ, Beattie RE, et al. TRP channels as emerging targets for pain therapeutics. Expert Opin Ther Targets. 2009;13(1):69-81.
Broad, L. M., Mogg, A. J., Beattie, R. E., Ogden, A. M., Blanco, M. J., & Bleakman, D. (2009). TRP channels as emerging targets for pain therapeutics. Expert Opinion On Therapeutic Targets, 13(1), 69-81. https://doi.org/10.1517/14728220802616620
Broad LM, et al. TRP Channels as Emerging Targets for Pain Therapeutics. Expert Opin Ther Targets. 2009;13(1):69-81. PubMed PMID: 19063707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRP channels as emerging targets for pain therapeutics. AU - Broad,Lisa M, AU - Mogg,Adrian J, AU - Beattie,Ruth E, AU - Ogden,Ann-Marie, AU - Blanco,Maria-Jesus, AU - Bleakman,David, PY - 2008/12/10/pubmed PY - 2009/3/3/medline PY - 2008/12/10/entrez SP - 69 EP - 81 JF - Expert opinion on therapeutic targets JO - Expert Opin Ther Targets VL - 13 IS - 1 N2 - BACKGROUND: The transient receptor potential (TRP) superfamily of ion channels are a large and diverse group that have received increased attention in recent years. The sub-family of thermo-TRPs which are regulated by temperature, among other physical and chemical stimuli, are of particular interest for the development of potential pain therapeutics. OBJECTIVE/METHODS: We review the advances in the field in recent years, focusing on a rationale for pain therapy and potential challenges associated with these targets. RESULTS/CONCLUSIONS: Vanilloid-type TRP 1 (TRPV1) is the most well studied and advanced member of the family, with selective agonists and antagonists already in clinical use or development, respectively. Among other thermo-TRPs (including TRPV2 - 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel pain targets. SN - 1744-7631 UR - https://www.unboundmedicine.com/medline/citation/19063707/TRP_channels_as_emerging_targets_for_pain_therapeutics_ L2 - https://www.tandfonline.com/doi/full/10.1517/14728220802616620 DB - PRIME DP - Unbound Medicine ER -