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The Klotho gene family as a regulator of endocrine fibroblast growth factors.
Mol Cell Endocrinol. 2009 Feb 05; 299(1):72-8.MC

Abstract

The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis. It has been shown that Klotho-deficient mice and Fgf23 knockout mice exhibit identical phenotypes. This observation led to the identification of Klotho as a cofactor essential for interactions between FGF23 and FGF receptors. In addition to the Klotho-FGF23 axis, recent studies has shown that betaKlotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21. This review summarizes recent progress in understanding of Klotho and betaKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23).

Authors+Show Affiliations

Department of Hygiene and Public Health I, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. kurosu78@research.twmu.ac.jpNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19063940

Citation

Kurosu, Hiroshi, and Makoto Kuro-O. "The Klotho Gene Family as a Regulator of Endocrine Fibroblast Growth Factors." Molecular and Cellular Endocrinology, vol. 299, no. 1, 2009, pp. 72-8.
Kurosu H, Kuro-O M. The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol. 2009;299(1):72-8.
Kurosu, H., & Kuro-O, M. (2009). The Klotho gene family as a regulator of endocrine fibroblast growth factors. Molecular and Cellular Endocrinology, 299(1), 72-8. https://doi.org/10.1016/j.mce.2008.10.052
Kurosu H, Kuro-O M. The Klotho Gene Family as a Regulator of Endocrine Fibroblast Growth Factors. Mol Cell Endocrinol. 2009 Feb 5;299(1):72-8. PubMed PMID: 19063940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Klotho gene family as a regulator of endocrine fibroblast growth factors. AU - Kurosu,Hiroshi, AU - Kuro-O,Makoto, Y1 - 2008/11/21/ PY - 2008/02/15/received PY - 2008/08/04/revised PY - 2008/10/27/accepted PY - 2008/12/10/pubmed PY - 2009/4/3/medline PY - 2008/12/10/entrez SP - 72 EP - 8 JF - Molecular and cellular endocrinology JO - Mol Cell Endocrinol VL - 299 IS - 1 N2 - The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vitamin D homeostasis. It has been shown that Klotho-deficient mice and Fgf23 knockout mice exhibit identical phenotypes. This observation led to the identification of Klotho as a cofactor essential for interactions between FGF23 and FGF receptors. In addition to the Klotho-FGF23 axis, recent studies has shown that betaKlotho, a Klotho family protein, also functions as a cofactor required for FGF19 and FGF21 signaling and determines the tissue-specific metabolic activities of FGF19 and FGF21. This review summarizes recent progress in understanding of Klotho and betaKlotho function in the regulation of tissue-specific metabolic activity of the endocrine fibroblast growth factors (FGF19, FGF21, and FGF23). SN - 0303-7207 UR - https://www.unboundmedicine.com/medline/citation/19063940/The_Klotho_gene_family_as_a_regulator_of_endocrine_fibroblast_growth_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(08)00524-8 DB - PRIME DP - Unbound Medicine ER -