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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
Bioorg Med Chem Lett. 2009 Jan 15; 19(2):524-7.BM

Abstract

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

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Authors+Show Affiliations

Czaplewski LG
Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.
Collins I
No affiliation info available
Boyd EA
No affiliation info available
Brown D
No affiliation info available
East SP
No affiliation info available
Gardiner M
No affiliation info available
Fletcher R
No affiliation info available
Haydon DJ
No affiliation info available
Henstock V
No affiliation info available
Ingram P
No affiliation info available
Jones C
No affiliation info available
Noula C
No affiliation info available
Kennison L
No affiliation info available
Rockley C
No affiliation info available
Rose V
No affiliation info available
Thomaides-Brears HB
No affiliation info available
Ure R
No affiliation info available
Whittaker M
No affiliation info available
Stokes NR
No affiliation info available

MeSH

Anti-Bacterial AgentsBacterial ProteinsBenzamidesCytoskeletal ProteinsMicrobial Sensitivity TestsStaphylococcusStructure-Activity Relationship

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19064318

Citation

Czaplewski, Lloyd G., et al. "Antibacterial Alkoxybenzamide Inhibitors of the Essential Bacterial Cell Division Protein FtsZ." Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 2, 2009, pp. 524-7.
Czaplewski LG, Collins I, Boyd EA, et al. Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorg Med Chem Lett. 2009;19(2):524-7.
Czaplewski, L. G., Collins, I., Boyd, E. A., Brown, D., East, S. P., Gardiner, M., Fletcher, R., Haydon, D. J., Henstock, V., Ingram, P., Jones, C., Noula, C., Kennison, L., Rockley, C., Rose, V., Thomaides-Brears, H. B., Ure, R., Whittaker, M., & Stokes, N. R. (2009). Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorganic & Medicinal Chemistry Letters, 19(2), 524-7. https://doi.org/10.1016/j.bmcl.2008.11.021
Czaplewski LG, et al. Antibacterial Alkoxybenzamide Inhibitors of the Essential Bacterial Cell Division Protein FtsZ. Bioorg Med Chem Lett. 2009 Jan 15;19(2):524-7. PubMed PMID: 19064318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. AU - Czaplewski,Lloyd G, AU - Collins,Ian, AU - Boyd,E Andrew, AU - Brown,David, AU - East,Stephen P, AU - Gardiner,Mihaly, AU - Fletcher,Rowena, AU - Haydon,David J, AU - Henstock,Vincent, AU - Ingram,Peter, AU - Jones,Clare, AU - Noula,Caterina, AU - Kennison,Leanne, AU - Rockley,Chris, AU - Rose,Valerie, AU - Thomaides-Brears,Helena B, AU - Ure,Rebecca, AU - Whittaker,Mark, AU - Stokes,Neil R, Y1 - 2008/11/13/ PY - 2008/10/02/received PY - 2008/11/07/revised PY - 2008/11/10/accepted PY - 2008/12/10/pubmed PY - 2009/3/3/medline PY - 2008/12/10/entrez SP - 524 EP - 7 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 19 IS - 2 N2 - 3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/19064318/Antibacterial_alkoxybenzamide_inhibitors_of_the_essential_bacterial_cell_division_protein_FtsZ_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(08)01389-9 DB - PRIME DP - Unbound Medicine ER -