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Dietary calcium, vitamin D, and the risk of colorectal cancer.
Am J Clin Nutr. 2008 Dec; 88(6):1576-83.AJ

Abstract

BACKGROUND

Calcium and vitamin D have a potential protective effect against colorectal cancer.

OBJECTIVE

We investigated the association of dietary intake of calcium and vitamin D with the risk of colorectal cancer in a large prospective cohort study of middle-aged Japanese men and women.

DESIGN

A total of 74 639 subjects (35 194 men and 39 445 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995-1999 to the end of 2004, during which time 761 cases of colorectal cancer (464 men, 297 women) were newly identified. Dietary intake of nutrients was calculated with the use of a 138-item self-administered food-frequency questionnaire.

RESULTS

After adjusting for potential confounding factors, the multivariate hazard ratio in the highest quintile of dietary calcium intake compared with the lowest was 0.71 (95% CI: 0.52, 0.98) among men. The association appeared to decrease considerably among subjects in the second quintile without a clear further dose-response relation (P for trend: 0.09). No association was seen among women. No statistically significant association with dietary vitamin D intake was seen in either men or women, although men in the highest dietary intake group of both nutrients had a lower risk than did men in the lowest group.

CONCLUSIONS

These findings indicate a potential decrease in the risk of colorectal cancer with higher dietary intake of calcium among middle-aged Japanese men, who have a relatively low dietary intake of calcium. Although vitamin D and colorectal cancer risk were not associated, potential effect modification between calcium and vitamin D on the risk of colorectal cancer was indicated.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ishihara J
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Inoue M
No affiliation info available
Iwasaki M
No affiliation info available
Sasazuki S
No affiliation info available
Tsugane S
No affiliation info available

MeSH

Bone Density Conservation AgentsCalcium, DietaryCohort StudiesColorectal NeoplasmsConfidence IntervalsDietFemaleFollow-Up StudiesHealth SurveysHumansJapanMaleMiddle AgedMultivariate AnalysisOdds RatioProspective StudiesRisk FactorsSex FactorsSurveys and QuestionnairesVitamin D

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19064518

Citation

Ishihara, Junko, et al. "Dietary Calcium, Vitamin D, and the Risk of Colorectal Cancer." The American Journal of Clinical Nutrition, vol. 88, no. 6, 2008, pp. 1576-83.
Ishihara J, Inoue M, Iwasaki M, et al. Dietary calcium, vitamin D, and the risk of colorectal cancer. Am J Clin Nutr. 2008;88(6):1576-83.
Ishihara, J., Inoue, M., Iwasaki, M., Sasazuki, S., & Tsugane, S. (2008). Dietary calcium, vitamin D, and the risk of colorectal cancer. The American Journal of Clinical Nutrition, 88(6), 1576-83. https://doi.org/10.3945/ajcn.2008.26195
Ishihara J, et al. Dietary Calcium, Vitamin D, and the Risk of Colorectal Cancer. Am J Clin Nutr. 2008;88(6):1576-83. PubMed PMID: 19064518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary calcium, vitamin D, and the risk of colorectal cancer. AU - Ishihara,Junko, AU - Inoue,Manami, AU - Iwasaki,Motoki, AU - Sasazuki,Shizuka, AU - Tsugane,Shoichiro, PY - 2008/12/10/pubmed PY - 2009/1/14/medline PY - 2008/12/10/entrez SP - 1576 EP - 83 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 88 IS - 6 N2 - BACKGROUND: Calcium and vitamin D have a potential protective effect against colorectal cancer. OBJECTIVE: We investigated the association of dietary intake of calcium and vitamin D with the risk of colorectal cancer in a large prospective cohort study of middle-aged Japanese men and women. DESIGN: A total of 74 639 subjects (35 194 men and 39 445 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995-1999 to the end of 2004, during which time 761 cases of colorectal cancer (464 men, 297 women) were newly identified. Dietary intake of nutrients was calculated with the use of a 138-item self-administered food-frequency questionnaire. RESULTS: After adjusting for potential confounding factors, the multivariate hazard ratio in the highest quintile of dietary calcium intake compared with the lowest was 0.71 (95% CI: 0.52, 0.98) among men. The association appeared to decrease considerably among subjects in the second quintile without a clear further dose-response relation (P for trend: 0.09). No association was seen among women. No statistically significant association with dietary vitamin D intake was seen in either men or women, although men in the highest dietary intake group of both nutrients had a lower risk than did men in the lowest group. CONCLUSIONS: These findings indicate a potential decrease in the risk of colorectal cancer with higher dietary intake of calcium among middle-aged Japanese men, who have a relatively low dietary intake of calcium. Although vitamin D and colorectal cancer risk were not associated, potential effect modification between calcium and vitamin D on the risk of colorectal cancer was indicated. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19064518/Dietary_calcium_vitamin_D_and_the_risk_of_colorectal_cancer_ DB - PRIME DP - Unbound Medicine ER -