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Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile.
Am J Clin Nutr 2008; 88(6):1648-52AJ

Abstract

BACKGROUND

Evidence from animal models suggests that fetal undernutrition can predispose to hypercholesterolemia and metabolic disorders directly by programming cholesterol metabolism and may indirectly influence lifestyle choices. We have shown that persons who were exposed to the Dutch famine in early gestation have a more atherogenic lipid profile.

OBJECTIVE

We now investigate whether the excess in hypercholesterolemia may be a result of a more atherogenic diet or a reduction in physical activity.

DESIGN

We measured lipid profiles, dietary intake, and physical activity in 730 men and women (aged 58 y) born in the Wilhelmina Gasthuis in Amsterdam, Netherlands, around the time of the Dutch famine, whose birth records have been kept.

RESULTS

No differences were observed in mean intake of total energy or percentage of protein, carbohydrate, and fat in the diet between the different exposure groups. However, persons exposed to famine in early gestation were twice as likely (odds ratio: 2.1; 95% CI: 1.2, 3.9) to consume a high-fat diet (defined as the highest quartile of percentage of fat in the diet: >39% of energy from fat). They also tended to be less physically active (45% did sports compared with 52% in the unexposed group), although this did not reach statistical significance.

CONCLUSIONS

This is the first direct evidence in humans that prenatal nutrition may affect dietary preferences and may contribute to more atherogenic lipid profiles in later life.

Authors+Show Affiliations

Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19064527

Citation

Lussana, Federico, et al. "Prenatal Exposure to the Dutch Famine Is Associated With a Preference for Fatty Foods and a More Atherogenic Lipid Profile." The American Journal of Clinical Nutrition, vol. 88, no. 6, 2008, pp. 1648-52.
Lussana F, Painter RC, Ocke MC, et al. Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile. Am J Clin Nutr. 2008;88(6):1648-52.
Lussana, F., Painter, R. C., Ocke, M. C., Buller, H. R., Bossuyt, P. M., & Roseboom, T. J. (2008). Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile. The American Journal of Clinical Nutrition, 88(6), pp. 1648-52. doi:10.3945/ajcn.2008.26140.
Lussana F, et al. Prenatal Exposure to the Dutch Famine Is Associated With a Preference for Fatty Foods and a More Atherogenic Lipid Profile. Am J Clin Nutr. 2008;88(6):1648-52. PubMed PMID: 19064527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile. AU - Lussana,Federico, AU - Painter,Rebecca C, AU - Ocke,Marga C, AU - Buller,Harry R, AU - Bossuyt,Patrick M, AU - Roseboom,Tessa J, PY - 2008/12/10/pubmed PY - 2009/1/14/medline PY - 2008/12/10/entrez SP - 1648 EP - 52 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 88 IS - 6 N2 - BACKGROUND: Evidence from animal models suggests that fetal undernutrition can predispose to hypercholesterolemia and metabolic disorders directly by programming cholesterol metabolism and may indirectly influence lifestyle choices. We have shown that persons who were exposed to the Dutch famine in early gestation have a more atherogenic lipid profile. OBJECTIVE: We now investigate whether the excess in hypercholesterolemia may be a result of a more atherogenic diet or a reduction in physical activity. DESIGN: We measured lipid profiles, dietary intake, and physical activity in 730 men and women (aged 58 y) born in the Wilhelmina Gasthuis in Amsterdam, Netherlands, around the time of the Dutch famine, whose birth records have been kept. RESULTS: No differences were observed in mean intake of total energy or percentage of protein, carbohydrate, and fat in the diet between the different exposure groups. However, persons exposed to famine in early gestation were twice as likely (odds ratio: 2.1; 95% CI: 1.2, 3.9) to consume a high-fat diet (defined as the highest quartile of percentage of fat in the diet: >39% of energy from fat). They also tended to be less physically active (45% did sports compared with 52% in the unexposed group), although this did not reach statistical significance. CONCLUSIONS: This is the first direct evidence in humans that prenatal nutrition may affect dietary preferences and may contribute to more atherogenic lipid profiles in later life. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19064527/Prenatal_exposure_to_the_Dutch_famine_is_associated_with_a_preference_for_fatty_foods_and_a_more_atherogenic_lipid_profile_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.26140 DB - PRIME DP - Unbound Medicine ER -