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Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis.
Cancer Epidemiol Biomarkers Prev. 2008 Dec; 17(12):3372-80.CE

Abstract

Hemodialysis patients face an elevated risk of cancer, arteriosclerosis, and other diseases, ascribed in part to increased oxidative stress. Red fruit juice with high anthocyanin/polyphenol content had been shown to reduce oxidative damage in healthy probands. To test its preventive potential in hemodialysis patients, 21 subjects in a pilot intervention study consumed 200 mL/day of red fruit juice (3-week run-in; 4-week juice uptake; 3-week wash-out). Weekly blood sampling was done to monitor DNA damage (comet assay +/- formamidopyrimidine-DNA glycosylase enzyme), glutathione, malondialdehyde, protein carbonyls, trolox equivalent antioxidant capacity, triglycerides, and DNA binding capacity of the transcription factor nuclear factor-kappaB. Results show a significant decrease of DNA oxidation damage (P < 0.0001), protein and lipid peroxidation (P < 0.0001 and P < 0.001, respectively), and nuclear factor-kappaB binding activity (P < 0.01), and an increase of glutathione level and status (both P < 0.0001) during juice uptake. We attribute this reduction in oxidative (cell) damage in hemodialysis patients to the especially high anthocyanin/polyphenol content of the juice. This provides promising perspectives into the prevention of chronic diseases such as cancer and cardiovascular disease in population subgroups exposed to enhanced oxidative stress like hemodialysis patients.

Authors+Show Affiliations

Department of Chemistry, Division of Food Chemistry and Toxicology, University of Kaiserslautern, Erwin-Schroedinger-Strasse 52, 67663 Kaiserslautern, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19064553

Citation

Spormann, Thomas M., et al. "Anthocyanin/polyphenolic-rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study With Patients On Hemodialysis." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 12, 2008, pp. 3372-80.
Spormann TM, Albert FW, Rath T, et al. Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3372-80.
Spormann, T. M., Albert, F. W., Rath, T., Dietrich, H., Will, F., Stockis, J. P., Eisenbrand, G., & Janzowski, C. (2008). Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(12), 3372-80. https://doi.org/10.1158/1055-9965.EPI-08-0364
Spormann TM, et al. Anthocyanin/polyphenolic-rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study With Patients On Hemodialysis. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3372-80. PubMed PMID: 19064553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. AU - Spormann,Thomas M, AU - Albert,Franz W, AU - Rath,Thomas, AU - Dietrich,Helmut, AU - Will,Frank, AU - Stockis,Jean-Pierre, AU - Eisenbrand,Gerhard, AU - Janzowski,Christine, PY - 2008/12/10/pubmed PY - 2009/1/28/medline PY - 2008/12/10/entrez SP - 3372 EP - 80 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 17 IS - 12 N2 - Hemodialysis patients face an elevated risk of cancer, arteriosclerosis, and other diseases, ascribed in part to increased oxidative stress. Red fruit juice with high anthocyanin/polyphenol content had been shown to reduce oxidative damage in healthy probands. To test its preventive potential in hemodialysis patients, 21 subjects in a pilot intervention study consumed 200 mL/day of red fruit juice (3-week run-in; 4-week juice uptake; 3-week wash-out). Weekly blood sampling was done to monitor DNA damage (comet assay +/- formamidopyrimidine-DNA glycosylase enzyme), glutathione, malondialdehyde, protein carbonyls, trolox equivalent antioxidant capacity, triglycerides, and DNA binding capacity of the transcription factor nuclear factor-kappaB. Results show a significant decrease of DNA oxidation damage (P < 0.0001), protein and lipid peroxidation (P < 0.0001 and P < 0.001, respectively), and nuclear factor-kappaB binding activity (P < 0.01), and an increase of glutathione level and status (both P < 0.0001) during juice uptake. We attribute this reduction in oxidative (cell) damage in hemodialysis patients to the especially high anthocyanin/polyphenol content of the juice. This provides promising perspectives into the prevention of chronic diseases such as cancer and cardiovascular disease in population subgroups exposed to enhanced oxidative stress like hemodialysis patients. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/19064553/Anthocyanin/polyphenolic_rich_fruit_juice_reduces_oxidative_cell_damage_in_an_intervention_study_with_patients_on_hemodialysis_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=19064553 DB - PRIME DP - Unbound Medicine ER -