Tags

Type your tag names separated by a space and hit enter

Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis.

Abstract

Hemodialysis patients face an elevated risk of cancer, arteriosclerosis, and other diseases, ascribed in part to increased oxidative stress. Red fruit juice with high anthocyanin/polyphenol content had been shown to reduce oxidative damage in healthy probands. To test its preventive potential in hemodialysis patients, 21 subjects in a pilot intervention study consumed 200 mL/day of red fruit juice (3-week run-in; 4-week juice uptake; 3-week wash-out). Weekly blood sampling was done to monitor DNA damage (comet assay +/- formamidopyrimidine-DNA glycosylase enzyme), glutathione, malondialdehyde, protein carbonyls, trolox equivalent antioxidant capacity, triglycerides, and DNA binding capacity of the transcription factor nuclear factor-kappaB. Results show a significant decrease of DNA oxidation damage (P < 0.0001), protein and lipid peroxidation (P < 0.0001 and P < 0.001, respectively), and nuclear factor-kappaB binding activity (P < 0.01), and an increase of glutathione level and status (both P < 0.0001) during juice uptake. We attribute this reduction in oxidative (cell) damage in hemodialysis patients to the especially high anthocyanin/polyphenol content of the juice. This provides promising perspectives into the prevention of chronic diseases such as cancer and cardiovascular disease in population subgroups exposed to enhanced oxidative stress like hemodialysis patients.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Chemistry, Division of Food Chemistry and Toxicology, University of Kaiserslautern, Erwin-Schroedinger-Strasse 52, 67663 Kaiserslautern, Germany.

    , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Analysis of Variance
    Anthocyanins
    Antioxidants
    Beverages
    Comet Assay
    DNA Damage
    Female
    Flavonoids
    Fruit
    Glutathione
    Humans
    Hydrazones
    Lipid Peroxidation
    Male
    Malondialdehyde
    Middle Aged
    NF-kappa B
    Oxidation-Reduction
    Phenols
    Pilot Projects
    Polyphenols
    Renal Dialysis
    Statistics, Nonparametric
    Triglycerides

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19064553

    Citation

    Spormann, Thomas M., et al. "Anthocyanin/polyphenolic-rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study With Patients On Hemodialysis." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 12, 2008, pp. 3372-80.
    Spormann TM, Albert FW, Rath T, et al. Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3372-80.
    Spormann, T. M., Albert, F. W., Rath, T., Dietrich, H., Will, F., Stockis, J. P., ... Janzowski, C. (2008). Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(12), pp. 3372-80. doi:10.1158/1055-9965.EPI-08-0364.
    Spormann TM, et al. Anthocyanin/polyphenolic-rich Fruit Juice Reduces Oxidative Cell Damage in an Intervention Study With Patients On Hemodialysis. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3372-80. PubMed PMID: 19064553.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis. AU - Spormann,Thomas M, AU - Albert,Franz W, AU - Rath,Thomas, AU - Dietrich,Helmut, AU - Will,Frank, AU - Stockis,Jean-Pierre, AU - Eisenbrand,Gerhard, AU - Janzowski,Christine, PY - 2008/12/10/pubmed PY - 2009/1/28/medline PY - 2008/12/10/entrez SP - 3372 EP - 80 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 12 N2 - Hemodialysis patients face an elevated risk of cancer, arteriosclerosis, and other diseases, ascribed in part to increased oxidative stress. Red fruit juice with high anthocyanin/polyphenol content had been shown to reduce oxidative damage in healthy probands. To test its preventive potential in hemodialysis patients, 21 subjects in a pilot intervention study consumed 200 mL/day of red fruit juice (3-week run-in; 4-week juice uptake; 3-week wash-out). Weekly blood sampling was done to monitor DNA damage (comet assay +/- formamidopyrimidine-DNA glycosylase enzyme), glutathione, malondialdehyde, protein carbonyls, trolox equivalent antioxidant capacity, triglycerides, and DNA binding capacity of the transcription factor nuclear factor-kappaB. Results show a significant decrease of DNA oxidation damage (P < 0.0001), protein and lipid peroxidation (P < 0.0001 and P < 0.001, respectively), and nuclear factor-kappaB binding activity (P < 0.01), and an increase of glutathione level and status (both P < 0.0001) during juice uptake. We attribute this reduction in oxidative (cell) damage in hemodialysis patients to the especially high anthocyanin/polyphenol content of the juice. This provides promising perspectives into the prevention of chronic diseases such as cancer and cardiovascular disease in population subgroups exposed to enhanced oxidative stress like hemodialysis patients. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/19064553/Anthocyanin/polyphenolic_rich_fruit_juice_reduces_oxidative_cell_damage_in_an_intervention_study_with_patients_on_hemodialysis_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=19064553 DB - PRIME DP - Unbound Medicine ER -