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[Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Dec; 25(6):653-6.ZY

Abstract

OBJECTIVE

To investigate the association of matrix metalloproteinase-3 (MMP-3) serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction (ACI) in a Chinese Han population.

METHODS

Two hundred and fifteen patients with acute ACI from the Department of Neurology of Taizhou Hospital and 226 healthy controls were included in the study. Serum MMP-3 level was measured by enzyme-linked immunosorbent assay (ELISA). Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the common 5A/6A functional promoter polymorphism of the MMP-3 gene.

RESULTS

The genotype distribution of the MMP-3 promoter 5A/6A polymorphism between the ACI patients group and the control group was significantly different (chi (2)= 9.389, P= 0.002). The frequencies of the 5A allele were 14.2% and 7.7% in the ACI patients group and the control group respectively (chi (2)= 9.430, P= 0.002). Serum level of MMP-3 in the ACI patients group was significantly higher than that in the control group (t= 24.867, P= 0.000). Among the ACI patients group, serum MMP-3 levels also had significant difference between the 5A/6A+ 5A/5A and the 6A/6A genotype (t= 2.057, P= 0.041).

CONCLUSION

The present findings suggest that serum level of MMP-3 obviously increased within 48 hours of ischemic stroke and the genetic polymorphism of 5A/6A in the MMP-3 promoter is associated with ACI and MMP-3 expression in the Chinese Han population.

Authors+Show Affiliations

Department of Neurology, the Affiliated Taizhou Hospital, Wenzhou Medical College, Taizhou, Zhejiang 317000, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19065524

Citation

Huang, Xiaoya, et al. "[Association of Matrix Metalloproteinase-3 Serum Level and the Promoter 5A/6A Polymorphism of the MMP-3 Gene With Atherosclerotic Cerebral Infarction]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 25, no. 6, 2008, pp. 653-6.
Huang X, Zhu M, Jin X, et al. [Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008;25(6):653-6.
Huang, X., Zhu, M., Jin, X., Zhang, D., Wang, L., & Ye, Z. (2008). [Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 25(6), 653-6.
Huang X, et al. [Association of Matrix Metalloproteinase-3 Serum Level and the Promoter 5A/6A Polymorphism of the MMP-3 Gene With Atherosclerotic Cerebral Infarction]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008;25(6):653-6. PubMed PMID: 19065524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction]. AU - Huang,Xiaoya, AU - Zhu,Min, AU - Jin,Xiaoping, AU - Zhang,Danhong, AU - Wang,Linzhi, AU - Ye,Zusen, PY - 2008/12/10/pubmed PY - 2009/3/26/medline PY - 2008/12/10/entrez SP - 653 EP - 6 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 25 IS - 6 N2 - OBJECTIVE: To investigate the association of matrix metalloproteinase-3 (MMP-3) serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction (ACI) in a Chinese Han population. METHODS: Two hundred and fifteen patients with acute ACI from the Department of Neurology of Taizhou Hospital and 226 healthy controls were included in the study. Serum MMP-3 level was measured by enzyme-linked immunosorbent assay (ELISA). Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the common 5A/6A functional promoter polymorphism of the MMP-3 gene. RESULTS: The genotype distribution of the MMP-3 promoter 5A/6A polymorphism between the ACI patients group and the control group was significantly different (chi (2)= 9.389, P= 0.002). The frequencies of the 5A allele were 14.2% and 7.7% in the ACI patients group and the control group respectively (chi (2)= 9.430, P= 0.002). Serum level of MMP-3 in the ACI patients group was significantly higher than that in the control group (t= 24.867, P= 0.000). Among the ACI patients group, serum MMP-3 levels also had significant difference between the 5A/6A+ 5A/5A and the 6A/6A genotype (t= 2.057, P= 0.041). CONCLUSION: The present findings suggest that serum level of MMP-3 obviously increased within 48 hours of ischemic stroke and the genetic polymorphism of 5A/6A in the MMP-3 promoter is associated with ACI and MMP-3 expression in the Chinese Han population. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/19065524/[Association_of_matrix_metalloproteinase_3_serum_level_and_the_promoter_5A/6A_polymorphism_of_the_MMP_3_gene_with_atherosclerotic_cerebral_infarction]_ DB - PRIME DP - Unbound Medicine ER -