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Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis?
Diabetes Metab Res Rev. 2009 Jan; 25(1):70-5.DM

Abstract

AIM

Hyperhomocystinaemia is associated with macro- and microangiopathic diabetic complications. However, the role of homocysteine (Hcy), serum folate, and vitamin B12 level in the development of premature vascular damage in type 2 diabetic patients is not clear. The present study was designed to assess the relationship between total Hcy, folate, and vitamin B12 levels and arterial stiffness, an early marker of generalized atherosclerosis.

METHODS

As many as 86 subjects with type 2 diabetes mellitus were studied. All participants were evaluated for glucose, HbA(1C), lipid profile, hs-CRP, endothelin, Hcy, vitamin B12, and folate. Pulse wave velocity (PWV) and augmentation index (AI) were performed as a non-invasive recording and computer analysis of the two artery sites pressure waveform using SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia).

RESULTS

Hcy was significantly positively associated with age, serum creatinine, and vitamin B12 levels. No association between Hcy and folate was observed. The Hcy concentration was significantly positively associated with PWV (r = 0.540, p < 0.0001) and AI (r = 0.390, p < 0.0001). In a general linear model of PWV, Hcy emerged as an independent predictor of PWV even after controlling for age, creatinine, vitamin B12, and folate levels. In a multiple linear regression analysis, the association between Hcy and arterial stiffness was independent of traditional cardiovascular risk factors. Vitamin B12 levels were significantly inversely associated with tHcy (r = - 0.263, p = 0.015) and marginally associated with PWV(r = - 0.212, p = 0.052). Significant associations between folate levels and PWV were not detected.

CONCLUSIONS

The results lend support to the hypothesis that elevated Hcy may have a key role in the development of atherogenesis in diabetic patients. Additionally, vitamin B12 is significantly associated with tHcy concentrations and is identified as a marginally independent correlate of PWV in diabetic patients in the absence of folate deficiency.

Authors+Show Affiliations

Department of Endocrinology, Wolfson Medical Center, Tel Aviv, Israel. marinas@wolfson.health.gov.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19065546

Citation

Shargorodsky, M, et al. "Serum Homocysteine, Folate, Vitamin B12 Levels and Arterial Stiffness in Diabetic Patients: Which of Them Is Really Important in Atherogenesis?" Diabetes/metabolism Research and Reviews, vol. 25, no. 1, 2009, pp. 70-5.
Shargorodsky M, Boaz M, Pasternak S, et al. Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis? Diabetes Metab Res Rev. 2009;25(1):70-5.
Shargorodsky, M., Boaz, M., Pasternak, S., Hanah, R., Matas, Z., Fux, A., Beigel, Y., & Mashavi, M. (2009). Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis? Diabetes/metabolism Research and Reviews, 25(1), 70-5. https://doi.org/10.1002/dmrr.902
Shargorodsky M, et al. Serum Homocysteine, Folate, Vitamin B12 Levels and Arterial Stiffness in Diabetic Patients: Which of Them Is Really Important in Atherogenesis. Diabetes Metab Res Rev. 2009;25(1):70-5. PubMed PMID: 19065546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis? AU - Shargorodsky,M, AU - Boaz,M, AU - Pasternak,S, AU - Hanah,R, AU - Matas,Z, AU - Fux,A, AU - Beigel,Y, AU - Mashavi,M, PY - 2008/12/10/pubmed PY - 2009/5/16/medline PY - 2008/12/10/entrez SP - 70 EP - 5 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab Res Rev VL - 25 IS - 1 N2 - AIM: Hyperhomocystinaemia is associated with macro- and microangiopathic diabetic complications. However, the role of homocysteine (Hcy), serum folate, and vitamin B12 level in the development of premature vascular damage in type 2 diabetic patients is not clear. The present study was designed to assess the relationship between total Hcy, folate, and vitamin B12 levels and arterial stiffness, an early marker of generalized atherosclerosis. METHODS: As many as 86 subjects with type 2 diabetes mellitus were studied. All participants were evaluated for glucose, HbA(1C), lipid profile, hs-CRP, endothelin, Hcy, vitamin B12, and folate. Pulse wave velocity (PWV) and augmentation index (AI) were performed as a non-invasive recording and computer analysis of the two artery sites pressure waveform using SphygmoCor (version 7.1, AtCor Medical, Sydney, Australia). RESULTS: Hcy was significantly positively associated with age, serum creatinine, and vitamin B12 levels. No association between Hcy and folate was observed. The Hcy concentration was significantly positively associated with PWV (r = 0.540, p < 0.0001) and AI (r = 0.390, p < 0.0001). In a general linear model of PWV, Hcy emerged as an independent predictor of PWV even after controlling for age, creatinine, vitamin B12, and folate levels. In a multiple linear regression analysis, the association between Hcy and arterial stiffness was independent of traditional cardiovascular risk factors. Vitamin B12 levels were significantly inversely associated with tHcy (r = - 0.263, p = 0.015) and marginally associated with PWV(r = - 0.212, p = 0.052). Significant associations between folate levels and PWV were not detected. CONCLUSIONS: The results lend support to the hypothesis that elevated Hcy may have a key role in the development of atherogenesis in diabetic patients. Additionally, vitamin B12 is significantly associated with tHcy concentrations and is identified as a marginally independent correlate of PWV in diabetic patients in the absence of folate deficiency. SN - 1520-7560 UR - https://www.unboundmedicine.com/medline/citation/19065546/Serum_homocysteine_folate_vitamin_B12_levels_and_arterial_stiffness_in_diabetic_patients:_which_of_them_is_really_important_in_atherogenesis L2 - https://doi.org/10.1002/dmrr.902 DB - PRIME DP - Unbound Medicine ER -