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Xenon-CT study of regional cerebral blood flow around hematoma in patients with basal ganglia hemorrhage.
Acta Neurochir Suppl. 2008; 105:161-4.AN

Abstract

BACKGROUND

Xenon-CT is a quantitive technique for estimating cerebral blood flow. To investigate whether penumbra exists around hematoma, regional cerebral blood flow (ICBF) was measured by Xenon-CT in patients with intracerebral hemorrhage (ICH).

METHODS

Xenon-CT was performed on 15 patients with basal ganglia hemorrhage and hematoma volume < 50 mL. rCBF was measured within 36 h of onset and an average of 13 days later by 27-pixel rings in perihematomal area and its enantiomorph in contralateral hemisphere. Penumbra was defined as rCBF 8-20 mL x 100 g(-1) x min(-1).

RESULTS

Average ICH volume was 13 +/- 7 mL (6.4-23.7 mL). First rCBF examination was conducted at 21.7 +/- 9.4 h (5-37 h), second rCBF examination was conducted at 13.4 +/- 1.8 days (11-18 days) after onset. Within 36h of onset, mean perihematomal rCBF was 28.4 +/- 7.8 mL x 100 g(-1) x min(-1); contralateral region was 34.2 +/- 12.2 mL x 100 g(-l) x min(-1) (p = 0.11). Average 13 days after onset, mean rCBF close to hematoma was 19.4 +/- 8.1 mL x 100 g(-1) x min(-1); rCBF in contralateral region was 40.1 +/- 11.3 mL x 100 g(-1) x min(-1) (p < 0.0001). rCBF in distal perihematomal region was 27.8 +/- 9.5 mL x 100 g(-1) x min(-1); the difference was significant compared to contralateral region (p = 0.0003). One patient's rCBF in area of edema around hematoma was less than 20 mL x 100 g(-1) x min(-1) at first examination. At second examination, 6 patients had same occurrence in region adjacent to hematoma and 2 patients experienced it in distal perihematomal region.

CONCLUSIONS

Reduced perihematomal rCBF was shown after ICH; this phenomenon lasted at least 14 days. A number of ICH patients experienced penumbra around hematoma.

Authors+Show Affiliations

Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19066103

Citation

Ding, H Y., et al. "Xenon-CT Study of Regional Cerebral Blood Flow Around Hematoma in Patients With Basal Ganglia Hemorrhage." Acta Neurochirurgica. Supplement, vol. 105, 2008, pp. 161-4.
Ding HY, Han X, Lv CZ, et al. Xenon-CT study of regional cerebral blood flow around hematoma in patients with basal ganglia hemorrhage. Acta Neurochir Suppl. 2008;105:161-4.
Ding, H. Y., Han, X., Lv, C. Z., & Dong, Q. (2008). Xenon-CT study of regional cerebral blood flow around hematoma in patients with basal ganglia hemorrhage. Acta Neurochirurgica. Supplement, 105, 161-4.
Ding HY, et al. Xenon-CT Study of Regional Cerebral Blood Flow Around Hematoma in Patients With Basal Ganglia Hemorrhage. Acta Neurochir Suppl. 2008;105:161-4. PubMed PMID: 19066103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xenon-CT study of regional cerebral blood flow around hematoma in patients with basal ganglia hemorrhage. AU - Ding,H Y, AU - Han,X, AU - Lv,C Z, AU - Dong,Q, PY - 2008/12/11/pubmed PY - 2009/4/15/medline PY - 2008/12/11/entrez SP - 161 EP - 4 JF - Acta neurochirurgica. Supplement JO - Acta Neurochir. Suppl. VL - 105 N2 - BACKGROUND: Xenon-CT is a quantitive technique for estimating cerebral blood flow. To investigate whether penumbra exists around hematoma, regional cerebral blood flow (ICBF) was measured by Xenon-CT in patients with intracerebral hemorrhage (ICH). METHODS: Xenon-CT was performed on 15 patients with basal ganglia hemorrhage and hematoma volume < 50 mL. rCBF was measured within 36 h of onset and an average of 13 days later by 27-pixel rings in perihematomal area and its enantiomorph in contralateral hemisphere. Penumbra was defined as rCBF 8-20 mL x 100 g(-1) x min(-1). RESULTS: Average ICH volume was 13 +/- 7 mL (6.4-23.7 mL). First rCBF examination was conducted at 21.7 +/- 9.4 h (5-37 h), second rCBF examination was conducted at 13.4 +/- 1.8 days (11-18 days) after onset. Within 36h of onset, mean perihematomal rCBF was 28.4 +/- 7.8 mL x 100 g(-1) x min(-1); contralateral region was 34.2 +/- 12.2 mL x 100 g(-l) x min(-1) (p = 0.11). Average 13 days after onset, mean rCBF close to hematoma was 19.4 +/- 8.1 mL x 100 g(-1) x min(-1); rCBF in contralateral region was 40.1 +/- 11.3 mL x 100 g(-1) x min(-1) (p < 0.0001). rCBF in distal perihematomal region was 27.8 +/- 9.5 mL x 100 g(-1) x min(-1); the difference was significant compared to contralateral region (p = 0.0003). One patient's rCBF in area of edema around hematoma was less than 20 mL x 100 g(-1) x min(-1) at first examination. At second examination, 6 patients had same occurrence in region adjacent to hematoma and 2 patients experienced it in distal perihematomal region. CONCLUSIONS: Reduced perihematomal rCBF was shown after ICH; this phenomenon lasted at least 14 days. A number of ICH patients experienced penumbra around hematoma. SN - 0065-1419 UR - https://www.unboundmedicine.com/medline/citation/19066103/Xenon_CT_study_of_regional_cerebral_blood_flow_around_hematoma_in_patients_with_basal_ganglia_hemorrhage_ L2 - https://medlineplus.gov/ctscans.html DB - PRIME DP - Unbound Medicine ER -