Tags

Type your tag names separated by a space and hit enter

Effect of taurine treatment on pro-oxidant-antioxidant balance in livers and brains of old rats.
Pharmacol Rep 2008 Sep-Oct; 60(5):673-8PR

Abstract

The effect of taurine treatment on antioxidant defense in liver and brain tissues of old rats was investigated. Endogenous malondialdehyde (MDA) and diene conjugate (DC), ascorbic acid (AA)- and NADPH-induced lipid peroxide levels as well as non-enzymatic (glutathione--GSH, vitamin E and vitamin C) and enzymatic antioxidants (superoxide dismutase, glutathione peroxidase and glutathione transferase) were determined in livers and brains of young (5 months), old (22 months), and taurine-treated old rats. Taurine (2%, w/v; in drinking water) was administered to old rats for 6 weeks. Taurine levels decreased in the liver and brain of old rats compared to young rats.MDA and DC levels increased, GSH levels decreased, but induced lipid peroxidation remained unchanged in livers of aged rats. Oxidative stress parameters did not change in brains of aged rats. Taurine treatment resulted in significant increases in taurine levels, decreases in MDA and DC levels and increases in GSH levels in livers of old rats. Taurine treatment also increased brain taurine levels. However, no significant changes were detected in lipid peroxidation and antioxidant system in brains of old rats following taurine treatment. Accordingly, in old rats the liver seems more susceptible to age-related lipid peroxidation increases and taurine level changes than the brain. Thus, taurine supplementation seems to be useful for decreasing hepatic oxidative stress in aging.

Authors+Show Affiliations

Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Capa, 34093, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19066413

Citation

Parildar-Karpuzoğlu, Hande, et al. "Effect of Taurine Treatment On Pro-oxidant-antioxidant Balance in Livers and Brains of Old Rats." Pharmacological Reports : PR, vol. 60, no. 5, 2008, pp. 673-8.
Parildar-Karpuzoğlu H, Mehmetçik G, Ozdemirler-Erata G, et al. Effect of taurine treatment on pro-oxidant-antioxidant balance in livers and brains of old rats. Pharmacol Rep. 2008;60(5):673-8.
Parildar-Karpuzoğlu, H., Mehmetçik, G., Ozdemirler-Erata, G., Doğru-Abbasoğlu, S., Koçak-Toker, N., & Uysal, M. (2008). Effect of taurine treatment on pro-oxidant-antioxidant balance in livers and brains of old rats. Pharmacological Reports : PR, 60(5), pp. 673-8.
Parildar-Karpuzoğlu H, et al. Effect of Taurine Treatment On Pro-oxidant-antioxidant Balance in Livers and Brains of Old Rats. Pharmacol Rep. 2008;60(5):673-8. PubMed PMID: 19066413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of taurine treatment on pro-oxidant-antioxidant balance in livers and brains of old rats. AU - Parildar-Karpuzoğlu,Hande, AU - Mehmetçik,Güldal, AU - Ozdemirler-Erata,Gül, AU - Doğru-Abbasoğlu,Semra, AU - Koçak-Toker,Necla, AU - Uysal,Müjdat, PY - 2008/02/20/received PY - 2008/09/17/revised PY - 2008/12/11/pubmed PY - 2009/2/21/medline PY - 2008/12/11/entrez SP - 673 EP - 8 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 60 IS - 5 N2 - The effect of taurine treatment on antioxidant defense in liver and brain tissues of old rats was investigated. Endogenous malondialdehyde (MDA) and diene conjugate (DC), ascorbic acid (AA)- and NADPH-induced lipid peroxide levels as well as non-enzymatic (glutathione--GSH, vitamin E and vitamin C) and enzymatic antioxidants (superoxide dismutase, glutathione peroxidase and glutathione transferase) were determined in livers and brains of young (5 months), old (22 months), and taurine-treated old rats. Taurine (2%, w/v; in drinking water) was administered to old rats for 6 weeks. Taurine levels decreased in the liver and brain of old rats compared to young rats.MDA and DC levels increased, GSH levels decreased, but induced lipid peroxidation remained unchanged in livers of aged rats. Oxidative stress parameters did not change in brains of aged rats. Taurine treatment resulted in significant increases in taurine levels, decreases in MDA and DC levels and increases in GSH levels in livers of old rats. Taurine treatment also increased brain taurine levels. However, no significant changes were detected in lipid peroxidation and antioxidant system in brains of old rats following taurine treatment. Accordingly, in old rats the liver seems more susceptible to age-related lipid peroxidation increases and taurine level changes than the brain. Thus, taurine supplementation seems to be useful for decreasing hepatic oxidative stress in aging. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/19066413/Effect_of_taurine_treatment_on_pro_oxidant_antioxidant_balance_in_livers_and_brains_of_old_rats_ L2 - http://www.if-pan.krakow.pl/pjp/pdf/2008/5_673.pdf DB - PRIME DP - Unbound Medicine ER -