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[Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters].
Vopr Virusol 2008 Sep-Oct; 53(5):41-5VV

Abstract

The essence of studies was that the disease is simulated in 12-day albino mice subcutaneously infected with Hantaan virus, strain 76-118 in a dose of 10 LD50. As an efficiency index, the study of drugs uses major (death protection coefficient, mean animal lifetime) and auxiliary (virological: pathogen accumulation in the brain tissues of deceased animals) parameters, biochemical (the levels of creatinine, urea, alanine aminotransferase, aspartate aminotransferase, malonic dialdehyde), hematological (count of leukocytes, leukogram) ones; as well as interferon status (the levels of circulatory interferon, leukocytic production of alpha- and gamma-interferons). The procedure for simulating the disease caused by Hantaan virus on an experimental animal is used to choose effective drugs against the pathogen of hemorrhagic nephrosonephritis.

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

19069793

Citation

Koval'chuk, A V., et al. "[Simulation of the Disease Caused By Hantaan Virus in White Mice By a Complex of Virological, Biochemical, and Hematological Parameters]." Voprosy Virusologii, vol. 53, no. 5, 2008, pp. 41-5.
Koval'chuk AV, Loginova SIa, Borisevich SV, et al. [Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters]. Vopr Virusol. 2008;53(5):41-5.
Koval'chuk, A. V., Loginova, S. I. a., Borisevich, S. V., Kopylova, N. K., Pashchenko, I. u. I., Khamitov, R. A., & Maksimov, V. A. (2008). [Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters]. Voprosy Virusologii, 53(5), pp. 41-5.
Koval'chuk AV, et al. [Simulation of the Disease Caused By Hantaan Virus in White Mice By a Complex of Virological, Biochemical, and Hematological Parameters]. Vopr Virusol. 2008;53(5):41-5. PubMed PMID: 19069793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Simulation of the disease caused by Hantaan virus in white mice by a complex of virological, biochemical, and hematological parameters]. AU - Koval'chuk,A V, AU - Loginova,S Ia, AU - Borisevich,S V, AU - Kopylova,N K, AU - Pashchenko,Iu I, AU - Khamitov,R A, AU - Maksimov,V A, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/1/16/medline SP - 41 EP - 5 JF - Voprosy virusologii JO - Vopr. Virusol. VL - 53 IS - 5 N2 - The essence of studies was that the disease is simulated in 12-day albino mice subcutaneously infected with Hantaan virus, strain 76-118 in a dose of 10 LD50. As an efficiency index, the study of drugs uses major (death protection coefficient, mean animal lifetime) and auxiliary (virological: pathogen accumulation in the brain tissues of deceased animals) parameters, biochemical (the levels of creatinine, urea, alanine aminotransferase, aspartate aminotransferase, malonic dialdehyde), hematological (count of leukocytes, leukogram) ones; as well as interferon status (the levels of circulatory interferon, leukocytic production of alpha- and gamma-interferons). The procedure for simulating the disease caused by Hantaan virus on an experimental animal is used to choose effective drugs against the pathogen of hemorrhagic nephrosonephritis. SN - 0507-4088 UR - https://www.unboundmedicine.com/medline/citation/19069793/[Simulation_of_the_disease_caused_by_Hantaan_virus_in_white_mice_by_a_complex_of_virological,_biochemical,_and_hematological_parameters] DB - PRIME DP - Unbound Medicine ER -