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Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis.
J Hepatol 2009; 50(2):351-7JH

Abstract

BACKGROUND/AIMS

Liver iron deposits are frequent in patients with non-alcoholic steato-hepatitis (NAFLD), but their role is not well defined. To investigate the effect of liver iron excess on the prevalence of hepatocellular carcinoma (HCC) in patients with NASH-related cirrhosis.

METHODS

Hepatic iron was measured retrospectively with a semiquantitative method in liver biopsies of 153 patients with NASH-related cirrhosis: 51 with HCC and 102 controls without HCC, matched for age, sex and stage of liver disease. The corrected total iron score (0-60) was the sum of three scores: the hepatocytic iron score (0-36), sinusoidal iron score (0-12), and portal iron score (0-12), multiplied by 3/3, 2/3, or 1/3 depending on the localisation of the iron in the nodules.

RESULTS

Conditional logistic regression analysis showed that iron deposits (corrected total iron score>0) were more frequent in HCC patients than in controls. The median corrected total iron score was significantly higher in HCC patients than in controls. The liver iron overload was sinusoidal.

CONCLUSIONS

Iron deposition in the liver was more frequent in patients with NASH-related cirrhosis with HCC than in HCC-free controls. Liver iron overload may be associated with development of HCC in patients with NASH-related cirrhosis.

Authors+Show Affiliations

Liver Unit, Clinical and Experimental Hepatology, Department of Internal Medicine, S.G. Moscati Hospital, Avellino, Italy. paolosorrmed@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19070395

Citation

Sorrentino, Paolo, et al. "Liver Iron Excess in Patients With Hepatocellular Carcinoma Developed On Non-alcoholic Steato-hepatitis." Journal of Hepatology, vol. 50, no. 2, 2009, pp. 351-7.
Sorrentino P, D'Angelo S, Ferbo U, et al. Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. J Hepatol. 2009;50(2):351-7.
Sorrentino, P., D'Angelo, S., Ferbo, U., Micheli, P., Bracigliano, A., & Vecchione, R. (2009). Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. Journal of Hepatology, 50(2), pp. 351-7. doi:10.1016/j.jhep.2008.09.011.
Sorrentino P, et al. Liver Iron Excess in Patients With Hepatocellular Carcinoma Developed On Non-alcoholic Steato-hepatitis. J Hepatol. 2009;50(2):351-7. PubMed PMID: 19070395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. AU - Sorrentino,Paolo, AU - D'Angelo,Salvatore, AU - Ferbo,Umberto, AU - Micheli,Pietro, AU - Bracigliano,Alessandra, AU - Vecchione,Raffaela, Y1 - 2008/11/14/ PY - 2008/04/10/received PY - 2008/07/04/revised PY - 2008/09/11/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/3/18/medline SP - 351 EP - 7 JF - Journal of hepatology JO - J. Hepatol. VL - 50 IS - 2 N2 - BACKGROUND/AIMS: Liver iron deposits are frequent in patients with non-alcoholic steato-hepatitis (NAFLD), but their role is not well defined. To investigate the effect of liver iron excess on the prevalence of hepatocellular carcinoma (HCC) in patients with NASH-related cirrhosis. METHODS: Hepatic iron was measured retrospectively with a semiquantitative method in liver biopsies of 153 patients with NASH-related cirrhosis: 51 with HCC and 102 controls without HCC, matched for age, sex and stage of liver disease. The corrected total iron score (0-60) was the sum of three scores: the hepatocytic iron score (0-36), sinusoidal iron score (0-12), and portal iron score (0-12), multiplied by 3/3, 2/3, or 1/3 depending on the localisation of the iron in the nodules. RESULTS: Conditional logistic regression analysis showed that iron deposits (corrected total iron score>0) were more frequent in HCC patients than in controls. The median corrected total iron score was significantly higher in HCC patients than in controls. The liver iron overload was sinusoidal. CONCLUSIONS: Iron deposition in the liver was more frequent in patients with NASH-related cirrhosis with HCC than in HCC-free controls. Liver iron overload may be associated with development of HCC in patients with NASH-related cirrhosis. SN - 0168-8278 UR - https://www.unboundmedicine.com/medline/citation/19070395/Liver_iron_excess_in_patients_with_hepatocellular_carcinoma_developed_on_non_alcoholic_steato_hepatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(08)00711-3 DB - PRIME DP - Unbound Medicine ER -