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Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model.
Food Chem Toxicol. 2009 Feb; 47(2):398-403.FC

Abstract

The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of Teucrium japonicum Houttuyn (Labiatae) (AXTJ) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXTJ inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXTJ decreased immunoglobulin E-mediated passive cutaneous anaphylaxis reaction. AXTJ reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. In addition, AXTJ attenuated activation of nuclear factor (NF)-kappaB, and downstream tumor necrosis factor (TNF)-alpha expression in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXTJ inhibits mast cell-derived allergic reactions and involvement of intracellular calcium, TNF-alpha, and NF-kappaB in these effects.

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Authors+Show Affiliations

Kim SH
IHBR, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea. shkim72@knu.ac.kr
Park SB
No affiliation info available
Kang SM
No affiliation info available
Jeon H
No affiliation info available
Lim JP
No affiliation info available
Kwon TK
No affiliation info available
Park WH
No affiliation info available
Kim HM
No affiliation info available
Shin TY
No affiliation info available

MeSH

AnimalsAnti-Allergic AgentsCalcimycinCalciumCells, CulturedHistamine AntagonistsHistamine ReleaseHypersensitivityIonophoresMast CellsNF-kappa BPhorbol EstersPlant ExtractsRatsTeucriumTumor Necrosis Factor-alphap-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19070642

Citation

Kim, Sang-Hyun, et al. "Anti-allergic Effects of Teucrium Japonicum On Mast Cell-mediated Allergy Model." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 2, 2009, pp. 398-403.
Kim SH, Park SB, Kang SM, et al. Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model. Food Chem Toxicol. 2009;47(2):398-403.
Kim, S. H., Park, S. B., Kang, S. M., Jeon, H., Lim, J. P., Kwon, T. K., Park, W. H., Kim, H. M., & Shin, T. Y. (2009). Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(2), 398-403. https://doi.org/10.1016/j.fct.2008.11.030
Kim SH, et al. Anti-allergic Effects of Teucrium Japonicum On Mast Cell-mediated Allergy Model. Food Chem Toxicol. 2009;47(2):398-403. PubMed PMID: 19070642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model. AU - Kim,Sang-Hyun, AU - Park,Seung-Bin, AU - Kang,Sin-Myoung, AU - Jeon,Hoon, AU - Lim,Jong-Pil, AU - Kwon,Taeg Kyu, AU - Park,Won-Hwan, AU - Kim,Hyung-Min, AU - Shin,Tae-Yong, Y1 - 2008/12/03/ PY - 2008/10/07/received PY - 2008/11/17/revised PY - 2008/11/25/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/2/20/medline SP - 398 EP - 403 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 2 N2 - The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of Teucrium japonicum Houttuyn (Labiatae) (AXTJ) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXTJ inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXTJ decreased immunoglobulin E-mediated passive cutaneous anaphylaxis reaction. AXTJ reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. In addition, AXTJ attenuated activation of nuclear factor (NF)-kappaB, and downstream tumor necrosis factor (TNF)-alpha expression in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXTJ inhibits mast cell-derived allergic reactions and involvement of intracellular calcium, TNF-alpha, and NF-kappaB in these effects. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19070642/Anti_allergic_effects_of_Teucrium_japonicum_on_mast_cell_mediated_allergy_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00663-7 DB - PRIME DP - Unbound Medicine ER -