Tags

Type your tag names separated by a space and hit enter

Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.
Int Immunopharmacol 2009; 9(2):216-22II

Abstract

Cannabidiol (CBD) is a cannabinoid component from Cannabis sativa that does not induce psychotomimetic effects and possess anti-inflammatory properties. In the present study we tested the effects of CBD in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying these effects. Periodontal disease was induced by a ligature placed around the mandible first molars of each animal. Male Wistar rats were divided into 3 groups: control animals; ligature-induced animals treated with vehicle and ligature-induced animals treated with CBD (5 mg/kg, daily). Thirty days after the induction of periodontal disease the animals were sacrificed and mandibles and gingival tissues removed for further analysis. Morphometrical analysis of alveolar bone loss demonstrated that CBD-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-kappaB ligand RANKL/RANK. Moreover, gingival tissues from the CBD-treated group showed decreased neutrophil migration (MPO assay) associated with lower interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha production. These results indicate that CBD may be useful to control bone resorption during progression of experimental periodontitis in rats.

Authors+Show Affiliations

Laboratory of Molecular Biology, University of Uberaba, Brazil. marcelo.napimoga@uniube.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19070683

Citation

Napimoga, Marcelo H., et al. "Cannabidiol Decreases Bone Resorption By Inhibiting RANK/RANKL Expression and Pro-inflammatory Cytokines During Experimental Periodontitis in Rats." International Immunopharmacology, vol. 9, no. 2, 2009, pp. 216-22.
Napimoga MH, Benatti BB, Lima FO, et al. Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats. Int Immunopharmacol. 2009;9(2):216-22.
Napimoga, M. H., Benatti, B. B., Lima, F. O., Alves, P. M., Campos, A. C., Pena-Dos-Santos, D. R., ... Guimarães, F. S. (2009). Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats. International Immunopharmacology, 9(2), pp. 216-22. doi:10.1016/j.intimp.2008.11.010.
Napimoga MH, et al. Cannabidiol Decreases Bone Resorption By Inhibiting RANK/RANKL Expression and Pro-inflammatory Cytokines During Experimental Periodontitis in Rats. Int Immunopharmacol. 2009;9(2):216-22. PubMed PMID: 19070683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats. AU - Napimoga,Marcelo H, AU - Benatti,Bruno B, AU - Lima,Flavia O, AU - Alves,Polyanna M, AU - Campos,Alline C, AU - Pena-Dos-Santos,Diego R, AU - Severino,Fernando P, AU - Cunha,Fernando Q, AU - Guimarães,Francisco S, Y1 - 2008/12/12/ PY - 2008/08/25/received PY - 2008/11/12/revised PY - 2008/11/13/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/5/1/medline SP - 216 EP - 22 JF - International immunopharmacology JO - Int. Immunopharmacol. VL - 9 IS - 2 N2 - Cannabidiol (CBD) is a cannabinoid component from Cannabis sativa that does not induce psychotomimetic effects and possess anti-inflammatory properties. In the present study we tested the effects of CBD in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying these effects. Periodontal disease was induced by a ligature placed around the mandible first molars of each animal. Male Wistar rats were divided into 3 groups: control animals; ligature-induced animals treated with vehicle and ligature-induced animals treated with CBD (5 mg/kg, daily). Thirty days after the induction of periodontal disease the animals were sacrificed and mandibles and gingival tissues removed for further analysis. Morphometrical analysis of alveolar bone loss demonstrated that CBD-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-kappaB ligand RANKL/RANK. Moreover, gingival tissues from the CBD-treated group showed decreased neutrophil migration (MPO assay) associated with lower interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha production. These results indicate that CBD may be useful to control bone resorption during progression of experimental periodontitis in rats. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/19070683/abstract/Cannabidiol_decreases_bone_resorption_by_inhibiting_RANK/RANKL_expression_and_pro_inflammatory_cytokines_during_experimental_periodontitis_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(08)00346-9 DB - PRIME DP - Unbound Medicine ER -