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RETRACTED ARTICLE

Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol.
Free Radic Biol Med 2009; 46(5):573-8FR

Abstract

Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine>resveratrol>tyrosol>hydroxytyrosol>red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol>red wine>hydroxytyrosol>white wine>tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.

Authors+Show Affiliations

Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, 06030-1110, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Retracted Publication

Language

eng

PubMed ID

19071213

Citation

Mukherjee, Subhendu, et al. "Expression of the Longevity Proteins By Both Red and White Wines and Their Cardioprotective Components, Resveratrol, Tyrosol, and Hydroxytyrosol." Free Radical Biology & Medicine, vol. 46, no. 5, 2009, pp. 573-8.
Mukherjee S, Lekli I, Gurusamy N, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med. 2009;46(5):573-8.
Mukherjee, S., Lekli, I., Gurusamy, N., Bertelli, A. A., & Das, D. K. (2009). Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radical Biology & Medicine, 46(5), pp. 573-8. doi:10.1016/j.freeradbiomed.2008.11.005.
Mukherjee S, et al. Expression of the Longevity Proteins By Both Red and White Wines and Their Cardioprotective Components, Resveratrol, Tyrosol, and Hydroxytyrosol. Free Radic Biol Med. 2009 Mar 1;46(5):573-8. PubMed PMID: 19071213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. AU - Mukherjee,Subhendu, AU - Lekli,Istvan, AU - Gurusamy,Narasimman, AU - Bertelli,Alberto A A, AU - Das,Dipak K, Y1 - 2008/11/24/ PY - 2008/09/02/received PY - 2008/10/15/revised PY - 2008/11/07/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/12/16/medline SP - 573 EP - 8 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 46 IS - 5 N2 - Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine>resveratrol>tyrosol>hydroxytyrosol>red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol>red wine>hydroxytyrosol>white wine>tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival. SN - 1873-4596 UR - https://www.unboundmedicine.com/medline/citation/19071213/Expression_of_the_longevity_proteins_by_both_red_and_white_wines_and_their_cardioprotective_components_resveratrol_tyrosol_and_hydroxytyrosol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(08)00711-9 DB - PRIME DP - Unbound Medicine ER -