Tags

Type your tag names separated by a space and hit enter

Direct enzymatic synthesis of a polyester with free pendant mercapto groups.
Biomacromolecules 2009; 10(2):366-73B

Abstract

An aliphatic polyester with free pendant mercapto groups was prepared by direct lipase-catalyzed polycondensation of hexane-1,6-diol and dimethyl 2-mercaptosuccinate. The polycondensation reaction using immobilized lipase from Candida antarctica (lipase CA) was carried out in bulk at 70 degrees C without any formation of disulfide or thioester linkages to produce the corresponding polyester with Mw = 14000 g/mol in high yield. The content of free mercapto groups in the polyester could be controlled by copolymerization with other monomers. The obtained polyester was easily cross-linked to form gels by the air oxidation of the pendant thiols to disulfides in dimethyl sulfoxide.

Authors+Show Affiliations

Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. dr064519@yahoo.co.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19072546

Citation

Kato, Makoto, et al. "Direct Enzymatic Synthesis of a Polyester With Free Pendant Mercapto Groups." Biomacromolecules, vol. 10, no. 2, 2009, pp. 366-73.
Kato M, Toshima K, Matsumura S. Direct enzymatic synthesis of a polyester with free pendant mercapto groups. Biomacromolecules. 2009;10(2):366-73.
Kato, M., Toshima, K., & Matsumura, S. (2009). Direct enzymatic synthesis of a polyester with free pendant mercapto groups. Biomacromolecules, 10(2), pp. 366-73. doi:10.1021/bm801132d.
Kato M, Toshima K, Matsumura S. Direct Enzymatic Synthesis of a Polyester With Free Pendant Mercapto Groups. Biomacromolecules. 2009 Feb 9;10(2):366-73. PubMed PMID: 19072546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Direct enzymatic synthesis of a polyester with free pendant mercapto groups. AU - Kato,Makoto, AU - Toshima,Kazunobu, AU - Matsumura,Shuichi, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/14/medline SP - 366 EP - 73 JF - Biomacromolecules JO - Biomacromolecules VL - 10 IS - 2 N2 - An aliphatic polyester with free pendant mercapto groups was prepared by direct lipase-catalyzed polycondensation of hexane-1,6-diol and dimethyl 2-mercaptosuccinate. The polycondensation reaction using immobilized lipase from Candida antarctica (lipase CA) was carried out in bulk at 70 degrees C without any formation of disulfide or thioester linkages to produce the corresponding polyester with Mw = 14000 g/mol in high yield. The content of free mercapto groups in the polyester could be controlled by copolymerization with other monomers. The obtained polyester was easily cross-linked to form gels by the air oxidation of the pendant thiols to disulfides in dimethyl sulfoxide. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/19072546/Direct_enzymatic_synthesis_of_a_polyester_with_free_pendant_mercapto_groups_ L2 - https://dx.doi.org/10.1021/bm801132d DB - PRIME DP - Unbound Medicine ER -