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What is the mechanism whereby cannabis use increases risk of psychosis?
Neurotox Res 2008; 14(2-3):105-12NR

Abstract

Cannabis use has increased greatly over the last three decades. The various types of cannabis differ in their concentration of the main psychoactive component, Delta-9-tetrahydrocannabinol (THC), and the other major ingredient, cannabidiol (CBD). Plant engineering has maximized levels of THC, thus increasing the potency of street cannabis. It is well known that cannabis intoxication can cause brief psychotic symptoms like paranoia, whilst recent evidence demonstrates that heavy use of cannabis increases the risk of chronic psychoses like schizophrenia; genetic vulnerability seems to predispose some people to a higher risk. This paper starts to consider the neurochemical mechanisms whereby cannabis use increases the risk of psychosis.

Authors+Show Affiliations

Institute of Psychiatry, Division of Psychological Medicine, Denmark Hill, London, SE5 8AF, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19073418

Citation

Luzi, Sonija, et al. "What Is the Mechanism Whereby Cannabis Use Increases Risk of Psychosis?" Neurotoxicity Research, vol. 14, no. 2-3, 2008, pp. 105-12.
Luzi S, Morrison PD, Powell J, et al. What is the mechanism whereby cannabis use increases risk of psychosis? Neurotox Res. 2008;14(2-3):105-12.
Luzi, S., Morrison, P. D., Powell, J., di Forti, M., & Murray, R. M. (2008). What is the mechanism whereby cannabis use increases risk of psychosis? Neurotoxicity Research, 14(2-3), pp. 105-12. doi:10.1007/BF03033802.
Luzi S, et al. What Is the Mechanism Whereby Cannabis Use Increases Risk of Psychosis. Neurotox Res. 2008;14(2-3):105-12. PubMed PMID: 19073418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What is the mechanism whereby cannabis use increases risk of psychosis? AU - Luzi,Sonija, AU - Morrison,Paul D, AU - Powell,John, AU - di Forti,Marta, AU - Murray,Robin M, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/1/medline SP - 105 EP - 12 JF - Neurotoxicity research JO - Neurotox Res VL - 14 IS - 2-3 N2 - Cannabis use has increased greatly over the last three decades. The various types of cannabis differ in their concentration of the main psychoactive component, Delta-9-tetrahydrocannabinol (THC), and the other major ingredient, cannabidiol (CBD). Plant engineering has maximized levels of THC, thus increasing the potency of street cannabis. It is well known that cannabis intoxication can cause brief psychotic symptoms like paranoia, whilst recent evidence demonstrates that heavy use of cannabis increases the risk of chronic psychoses like schizophrenia; genetic vulnerability seems to predispose some people to a higher risk. This paper starts to consider the neurochemical mechanisms whereby cannabis use increases the risk of psychosis. SN - 1029-8428 UR - https://www.unboundmedicine.com/medline/citation/19073418/What_is_the_mechanism_whereby_cannabis_use_increases_risk_of_psychosis L2 - https://dx.doi.org/10.1007/BF03033802 DB - PRIME DP - Unbound Medicine ER -