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Does the level of soluble intercellular adhesion molecule 1 predict myocardial injury before cardiac markers increase?
Heart Surg Forum. 2008 Dec; 11(6):E352-6.HS

Abstract

BACKGROUND

The measurement of cardiac markers is still the gold standard for diagnosing myocardial infarction (MI), but there is always a transition period between the time of infarction and when a marker can be measured in the blood. Therefore, clinicians are shifting their focus to the identification of potential new analytes capable of predicting MIs before the standard cardiac markers increase. In this study, we tested whether measurement of the concentration of soluble intercellular adhesion molecule 1 (sICAM-1) in plasma can be used for this purpose.

MATERIALS AND METHODS

In this prospective study, we included 60 male patients who had a left main coronary artery lesion or a left main equivalent and who underwent elective (group I, n = 20), urgent (group II, n = 20), or emergent (group III, n = 20) coronary artery bypass grafting (CABG). We excluded patients who had increased cardiac markers at admission, and drew blood samples for sICAM-1 measurements from other patients immediately after coronary angiography evaluations. We divided the patients into 3 groups according to their clinical characteristics and cardiac marker levels. Only patients with increased cardiac markers underwent emergent CABG (group III). We measured sICAM-1 concentrations immediately after coronary angiography and measured creatine kinase MB (CK-MB) and cardiac troponin I (cTnI) just before CABG. We then evaluated the results for correlations.

RESULTS

CK-MB, cTnI, and sICAM-1 levels were significantly higher in group III than in groups I and II (P < .05 for all). Our analysis for correlations between the sICAM-1 level and cardiac marker levels revealed no significant correlations in group I (CK-MB, r = 0.241 [P = .15]; cTnI, r = -0.107 [P = .32]) and group II (CK-MB, r = -0.202 [P = .19]; cTnI, r = 0.606 [P = .002]), but our analysis did reveal highly significant correlations in group III (CK-MB, r = 0.584 [P = .003]; cTnI, r = 0.605 [P = .002]).

CONCLUSION

Measuring the plasma concentration of sICAM-1 before the concentrations of cardiac markers increase in patients with MI may provide clinicians with faster and reliable data for deciding on and administering the most appropriate procedures and/or therapies.

Authors+Show Affiliations

Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19073540

Citation

Iyigun, Taner, et al. "Does the Level of Soluble Intercellular Adhesion Molecule 1 Predict Myocardial Injury Before Cardiac Markers Increase?" The Heart Surgery Forum, vol. 11, no. 6, 2008, pp. E352-6.
Iyigun T, Teskin O, Enc Y, et al. Does the level of soluble intercellular adhesion molecule 1 predict myocardial injury before cardiac markers increase? Heart Surg Forum. 2008;11(6):E352-6.
Iyigun, T., Teskin, O., Enc, Y., Cakmak, M., Iyigun, M., Keser, S., Camur, G., Komurcu, G., Sargin, M., Ozay, B., & Dagsali, S. (2008). Does the level of soluble intercellular adhesion molecule 1 predict myocardial injury before cardiac markers increase? The Heart Surgery Forum, 11(6), E352-6. https://doi.org/10.1532/HSF98.20081092
Iyigun T, et al. Does the Level of Soluble Intercellular Adhesion Molecule 1 Predict Myocardial Injury Before Cardiac Markers Increase. Heart Surg Forum. 2008;11(6):E352-6. PubMed PMID: 19073540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does the level of soluble intercellular adhesion molecule 1 predict myocardial injury before cardiac markers increase? AU - Iyigun,Taner, AU - Teskin,Onder, AU - Enc,Yavuz, AU - Cakmak,Mahmut, AU - Iyigun,Muzeyyen, AU - Keser,Suheyla, AU - Camur,Gercek, AU - Komurcu,Gurkan, AU - Sargin,Murat, AU - Ozay,Batuhan, AU - Dagsali,Sabri, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/16/medline SP - E352 EP - 6 JF - The heart surgery forum JO - Heart Surg Forum VL - 11 IS - 6 N2 - BACKGROUND: The measurement of cardiac markers is still the gold standard for diagnosing myocardial infarction (MI), but there is always a transition period between the time of infarction and when a marker can be measured in the blood. Therefore, clinicians are shifting their focus to the identification of potential new analytes capable of predicting MIs before the standard cardiac markers increase. In this study, we tested whether measurement of the concentration of soluble intercellular adhesion molecule 1 (sICAM-1) in plasma can be used for this purpose. MATERIALS AND METHODS: In this prospective study, we included 60 male patients who had a left main coronary artery lesion or a left main equivalent and who underwent elective (group I, n = 20), urgent (group II, n = 20), or emergent (group III, n = 20) coronary artery bypass grafting (CABG). We excluded patients who had increased cardiac markers at admission, and drew blood samples for sICAM-1 measurements from other patients immediately after coronary angiography evaluations. We divided the patients into 3 groups according to their clinical characteristics and cardiac marker levels. Only patients with increased cardiac markers underwent emergent CABG (group III). We measured sICAM-1 concentrations immediately after coronary angiography and measured creatine kinase MB (CK-MB) and cardiac troponin I (cTnI) just before CABG. We then evaluated the results for correlations. RESULTS: CK-MB, cTnI, and sICAM-1 levels were significantly higher in group III than in groups I and II (P < .05 for all). Our analysis for correlations between the sICAM-1 level and cardiac marker levels revealed no significant correlations in group I (CK-MB, r = 0.241 [P = .15]; cTnI, r = -0.107 [P = .32]) and group II (CK-MB, r = -0.202 [P = .19]; cTnI, r = 0.606 [P = .002]), but our analysis did reveal highly significant correlations in group III (CK-MB, r = 0.584 [P = .003]; cTnI, r = 0.605 [P = .002]). CONCLUSION: Measuring the plasma concentration of sICAM-1 before the concentrations of cardiac markers increase in patients with MI may provide clinicians with faster and reliable data for deciding on and administering the most appropriate procedures and/or therapies. SN - 1522-6662 UR - https://www.unboundmedicine.com/medline/citation/19073540/Does_the_level_of_soluble_intercellular_adhesion_molecule_1_predict_myocardial_injury_before_cardiac_markers_increase L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -