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Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis.

Abstract

BACKGROUND

Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life, and has a greater mortality risk than Alzheimer's disease among the elderly population group. The angiotensin-converting enzyme insertion/deletion polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the insertion/deletion polymorphism on the vascular dementia.

METHODS

We applied a random-effects model or fixed-effects model to combine odds ratio and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias.

RESULTS

A total of 10 studies were included worldwide. Publication bias was not observed. There was no evidence of the association of angiotensin-converting enzyme insertion/deletion polymorphism with the vascular dementia in general or in the Asian populations or in the Caucasian populations.

CONCLUSIONS

The angiotensin-converting enzyme insertion/deletion polymorphism might be neutral to vascular dementia.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, PR China.

    , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Dementia, Vascular
    Female
    Genetic Predisposition to Disease
    Humans
    INDEL Mutation
    Male
    Middle Aged
    Peptidyl-Dipeptidase A
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    19073835

    Citation

    Liu, Hua, et al. "Association of ACE I/D Gene Polymorphism With Vascular Dementia: a Meta-analysis." Journal of Geriatric Psychiatry and Neurology, vol. 22, no. 1, 2009, pp. 10-22.
    Liu H, Liu M, Li W, et al. Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. J Geriatr Psychiatry Neurol. 2009;22(1):10-22.
    Liu, H., Liu, M., Li, W., Wu, B., Zhang, S. H., Fang, Y., & Wang, Y. (2009). Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. Journal of Geriatric Psychiatry and Neurology, 22(1), pp. 10-22. doi:10.1177/0891988708328221.
    Liu H, et al. Association of ACE I/D Gene Polymorphism With Vascular Dementia: a Meta-analysis. J Geriatr Psychiatry Neurol. 2009;22(1):10-22. PubMed PMID: 19073835.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. AU - Liu,Hua, AU - Liu,Ming, AU - Li,Wei, AU - Wu,Bo, AU - Zhang,Shi-hong, AU - Fang,Yuan, AU - Wang,Yi, Y1 - 2008/12/10/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/17/medline SP - 10 EP - 22 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 22 IS - 1 N2 - BACKGROUND: Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life, and has a greater mortality risk than Alzheimer's disease among the elderly population group. The angiotensin-converting enzyme insertion/deletion polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the insertion/deletion polymorphism on the vascular dementia. METHODS: We applied a random-effects model or fixed-effects model to combine odds ratio and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias. RESULTS: A total of 10 studies were included worldwide. Publication bias was not observed. There was no evidence of the association of angiotensin-converting enzyme insertion/deletion polymorphism with the vascular dementia in general or in the Asian populations or in the Caucasian populations. CONCLUSIONS: The angiotensin-converting enzyme insertion/deletion polymorphism might be neutral to vascular dementia. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/19073835/Association_of_ACE_I/D_gene_polymorphism_with_vascular_dementia:_a_meta_analysis_ L2 - http://journals.sagepub.com/doi/full/10.1177/0891988708328221?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -