Tags

Type your tag names separated by a space and hit enter

Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis.
J Geriatr Psychiatry Neurol 2009; 22(1):10-22JG

Abstract

BACKGROUND

Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life, and has a greater mortality risk than Alzheimer's disease among the elderly population group. The angiotensin-converting enzyme insertion/deletion polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the insertion/deletion polymorphism on the vascular dementia.

METHODS

We applied a random-effects model or fixed-effects model to combine odds ratio and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias.

RESULTS

A total of 10 studies were included worldwide. Publication bias was not observed. There was no evidence of the association of angiotensin-converting enzyme insertion/deletion polymorphism with the vascular dementia in general or in the Asian populations or in the Caucasian populations.

CONCLUSIONS

The angiotensin-converting enzyme insertion/deletion polymorphism might be neutral to vascular dementia.

Authors+Show Affiliations

Department of Neurology, West China Hospital, Sichuan University, Sichuan Province, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

19073835

Citation

Liu, Hua, et al. "Association of ACE I/D Gene Polymorphism With Vascular Dementia: a Meta-analysis." Journal of Geriatric Psychiatry and Neurology, vol. 22, no. 1, 2009, pp. 10-22.
Liu H, Liu M, Li W, et al. Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. J Geriatr Psychiatry Neurol. 2009;22(1):10-22.
Liu, H., Liu, M., Li, W., Wu, B., Zhang, S. H., Fang, Y., & Wang, Y. (2009). Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. Journal of Geriatric Psychiatry and Neurology, 22(1), pp. 10-22. doi:10.1177/0891988708328221.
Liu H, et al. Association of ACE I/D Gene Polymorphism With Vascular Dementia: a Meta-analysis. J Geriatr Psychiatry Neurol. 2009;22(1):10-22. PubMed PMID: 19073835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of ACE I/D gene polymorphism with vascular dementia: a meta-analysis. AU - Liu,Hua, AU - Liu,Ming, AU - Li,Wei, AU - Wu,Bo, AU - Zhang,Shi-hong, AU - Fang,Yuan, AU - Wang,Yi, Y1 - 2008/12/10/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/17/medline SP - 10 EP - 22 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 22 IS - 1 N2 - BACKGROUND: Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life, and has a greater mortality risk than Alzheimer's disease among the elderly population group. The angiotensin-converting enzyme insertion/deletion polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the insertion/deletion polymorphism on the vascular dementia. METHODS: We applied a random-effects model or fixed-effects model to combine odds ratio and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias. RESULTS: A total of 10 studies were included worldwide. Publication bias was not observed. There was no evidence of the association of angiotensin-converting enzyme insertion/deletion polymorphism with the vascular dementia in general or in the Asian populations or in the Caucasian populations. CONCLUSIONS: The angiotensin-converting enzyme insertion/deletion polymorphism might be neutral to vascular dementia. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/19073835/Association_of_ACE_I/D_gene_polymorphism_with_vascular_dementia:_a_meta_analysis_ L2 - http://journals.sagepub.com/doi/full/10.1177/0891988708328221?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -