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Risk of Parkinson's disease after hospital contact for head injury: population based case-control study.
BMJ 2008; 337:a2494BMJ

Abstract

OBJECTIVE

To determine whether a hospital contact for a head injury increases the risk of subsequently developing Parkinson's disease.

DESIGN

Population based case-control study.

SETTING

Denmark.

PARTICIPANTS

13 695 patients with a primary diagnosis of Parkinson's disease in the Danish national hospital register during 1986-2006, each matched on age and sex to five population controls selected at random from inhabitants in Denmark alive at the date of the patient's diagnosis (n=68 445).

MAIN OUTCOME MEASURES

Hospital contacts for head injuries ascertained from hospital register; frequency of history of head injury.

RESULTS

An overall 50% increase in prevalence of hospital contacts for head injury was seen before the first registration of Parkinson's disease in this population (odds ratio 1.5, 95% confidence interval 1.4 to 1.7). The observed association was, however, due almost entirely to injuries that occurred during the three months before the first record of Parkinson's disease (odds ratio 8.0, 5.6 to 11.6), and no association was found between the two events when they occurred 10 or more years apart (1.1, 0.9 to 1.3).

CONCLUSIONS

The steeply increased frequency of hospital contacts for a head injury during the months preceding the date at which Parkinson's disease was first recorded is a consequence of the evolving movement disorder rather than its cause.

Authors+Show Affiliations

Institute of Cancer Epidemiology, Danish Cancer Society, 49 Strandboulevarden, DK-2100 Copenhagen, Denmark. rugbjerg@cancer.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19074944

Citation

Rugbjerg, Kathrine, et al. "Risk of Parkinson's Disease After Hospital Contact for Head Injury: Population Based Case-control Study." BMJ (Clinical Research Ed.), vol. 337, 2008, pp. a2494.
Rugbjerg K, Ritz B, Korbo L, et al. Risk of Parkinson's disease after hospital contact for head injury: population based case-control study. BMJ. 2008;337:a2494.
Rugbjerg, K., Ritz, B., Korbo, L., Martinussen, N., & Olsen, J. H. (2008). Risk of Parkinson's disease after hospital contact for head injury: population based case-control study. BMJ (Clinical Research Ed.), 337, pp. a2494. doi:10.1136/bmj.a2494.
Rugbjerg K, et al. Risk of Parkinson's Disease After Hospital Contact for Head Injury: Population Based Case-control Study. BMJ. 2008 Dec 15;337:a2494. PubMed PMID: 19074944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of Parkinson's disease after hospital contact for head injury: population based case-control study. AU - Rugbjerg,Kathrine, AU - Ritz,Beate, AU - Korbo,Lise, AU - Martinussen,Nick, AU - Olsen,Jørgen H, Y1 - 2008/12/15/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/1/22/medline SP - a2494 EP - a2494 JF - BMJ (Clinical research ed.) JO - BMJ VL - 337 N2 - OBJECTIVE: To determine whether a hospital contact for a head injury increases the risk of subsequently developing Parkinson's disease. DESIGN: Population based case-control study. SETTING: Denmark. PARTICIPANTS: 13 695 patients with a primary diagnosis of Parkinson's disease in the Danish national hospital register during 1986-2006, each matched on age and sex to five population controls selected at random from inhabitants in Denmark alive at the date of the patient's diagnosis (n=68 445). MAIN OUTCOME MEASURES: Hospital contacts for head injuries ascertained from hospital register; frequency of history of head injury. RESULTS: An overall 50% increase in prevalence of hospital contacts for head injury was seen before the first registration of Parkinson's disease in this population (odds ratio 1.5, 95% confidence interval 1.4 to 1.7). The observed association was, however, due almost entirely to injuries that occurred during the three months before the first record of Parkinson's disease (odds ratio 8.0, 5.6 to 11.6), and no association was found between the two events when they occurred 10 or more years apart (1.1, 0.9 to 1.3). CONCLUSIONS: The steeply increased frequency of hospital contacts for a head injury during the months preceding the date at which Parkinson's disease was first recorded is a consequence of the evolving movement disorder rather than its cause. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/19074944/Risk_of_Parkinson's_disease_after_hospital_contact_for_head_injury:_population_based_case_control_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=19074944 DB - PRIME DP - Unbound Medicine ER -