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Effect of ageing and body mass index on prostate-specific antigen levels among Chinese men in Singapore from a community-based study.
BJU Int. 2009 Jun; 103(11):1487-91.BI

Abstract

OBJECTIVE

To assess the effect of ageing and body mass index (BMI) on prostate-specific antigen (PSA) among Chinese men from the results of the 2005 Prostate Awareness Week in Singapore. SUBJECTS AND

METHODS

In all, 2714 men participated in the programme, consisting of 2431 Chinese, 114 Malays, 117 Indians and 52 'others'. Of these, 2410 Chinese men who had a PSA level of <20 ng/mL and were aged >50 years but <80 years were included in the analysis. Height and weight were used to calculate the BMI. The relationship between age and PSA levels was analysed using linear regression and bivariate correlation, and the associations among different groups of BMI and PSA levels were analysed using analysis of variance and covariance.

RESULTS

PSA levels were significantly correlated with age (correlation coefficient, r = 0.27, P < 0.001). Analyses showed a significant inverse association between PSA level and BMI; mean PSA levels decreased with increasing BMI for both standards (standard classification; geometric mean, GM, PSA of 1.08, 1.06, 0.96, 0.83 ng/mL for a BMI of <18.5, 18.5-24.9, 25-29.9 and > or =30 kg/m(2), respectively, P trend <0.01; and for Asian classification, GM PSA 1.08, 1.09, 0.96, 0.91 ng/mL for a BMI of <18.5, 18.5-22.9, 23-27.5 and > or =27.5, respectively, P trend <0.001). There were significant differences (P < 0.05) in the age-adjusted GM PSA levels for the groups with BMI <25 (1.05 ng/mL) and BMI > or =25 kg/m(2) (0.97 ng/mL). Similarly, there were significant differences (P < 0.05) in the age-adjusted GM PSA levels in those with a BMI of <30 (1.03 ng/mL) and > or =30 kg/m(2) (0.85 ng/mL).

CONCLUSION

These data suggest that the BMI in Chinese men in Singapore is significantly associated with PSA levels, especially among the obese men aged 70-79 years.

Authors+Show Affiliations

Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. sin_eng_chia@nuhs.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19076145

Citation

Chia, Sin-Eng, et al. "Effect of Ageing and Body Mass Index On Prostate-specific Antigen Levels Among Chinese Men in Singapore From a Community-based Study." BJU International, vol. 103, no. 11, 2009, pp. 1487-91.
Chia SE, Lau WK, Chin CM, et al. Effect of ageing and body mass index on prostate-specific antigen levels among Chinese men in Singapore from a community-based study. BJU Int. 2009;103(11):1487-91.
Chia, S. E., Lau, W. K., Chin, C. M., Tan, J., Ho, S. H., Lee, J., & Cheng, C. (2009). Effect of ageing and body mass index on prostate-specific antigen levels among Chinese men in Singapore from a community-based study. BJU International, 103(11), 1487-91. https://doi.org/10.1111/j.1464-410X.2008.08246.x
Chia SE, et al. Effect of Ageing and Body Mass Index On Prostate-specific Antigen Levels Among Chinese Men in Singapore From a Community-based Study. BJU Int. 2009;103(11):1487-91. PubMed PMID: 19076145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ageing and body mass index on prostate-specific antigen levels among Chinese men in Singapore from a community-based study. AU - Chia,Sin-Eng, AU - Lau,Weber K O, AU - Chin,Chong Min, AU - Tan,James, AU - Ho,Siew Hong, AU - Lee,June, AU - Cheng,Christopher, Y1 - 2008/12/08/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/6/30/medline SP - 1487 EP - 91 JF - BJU international JO - BJU Int VL - 103 IS - 11 N2 - OBJECTIVE To assess the effect of ageing and body mass index (BMI) on prostate-specific antigen (PSA) among Chinese men from the results of the 2005 Prostate Awareness Week in Singapore. SUBJECTS AND METHODS In all, 2714 men participated in the programme, consisting of 2431 Chinese, 114 Malays, 117 Indians and 52 'others'. Of these, 2410 Chinese men who had a PSA level of <20 ng/mL and were aged >50 years but <80 years were included in the analysis. Height and weight were used to calculate the BMI. The relationship between age and PSA levels was analysed using linear regression and bivariate correlation, and the associations among different groups of BMI and PSA levels were analysed using analysis of variance and covariance. RESULTS PSA levels were significantly correlated with age (correlation coefficient, r = 0.27, P < 0.001). Analyses showed a significant inverse association between PSA level and BMI; mean PSA levels decreased with increasing BMI for both standards (standard classification; geometric mean, GM, PSA of 1.08, 1.06, 0.96, 0.83 ng/mL for a BMI of <18.5, 18.5-24.9, 25-29.9 and > or =30 kg/m(2), respectively, P trend <0.01; and for Asian classification, GM PSA 1.08, 1.09, 0.96, 0.91 ng/mL for a BMI of <18.5, 18.5-22.9, 23-27.5 and > or =27.5, respectively, P trend <0.001). There were significant differences (P < 0.05) in the age-adjusted GM PSA levels for the groups with BMI <25 (1.05 ng/mL) and BMI > or =25 kg/m(2) (0.97 ng/mL). Similarly, there were significant differences (P < 0.05) in the age-adjusted GM PSA levels in those with a BMI of <30 (1.03 ng/mL) and > or =30 kg/m(2) (0.85 ng/mL). CONCLUSION These data suggest that the BMI in Chinese men in Singapore is significantly associated with PSA levels, especially among the obese men aged 70-79 years. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/19076145/Effect_of_ageing_and_body_mass_index_on_prostate_specific_antigen_levels_among_Chinese_men_in_Singapore_from_a_community_based_study_ L2 - https://doi.org/10.1111/j.1464-410X.2008.08246.x DB - PRIME DP - Unbound Medicine ER -