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Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents.
Pediatr Diabetes. 2009 Aug; 10(5):329-35.PD

Abstract

BACKGROUND

Overweight and the metabolic syndrome (MS) represent dramatically increasing problems in children and adolescents. Waist circumference (WC) is an important factor to determine MS. So far, WC is a predictor of blood pressure, high-density lipoprotein (HDL), insulin concentration, and visceral fat in adolescents. We investigated whether WC and body mass index standard deviation score (BMI-SDS) are predictors of adiponectin, stromal-derived factor (SDF-1), and soluble E-selectin (sE-selectin) as parameters for beginning insulin resistance and endothelial damage.

METHODS

Seventy-nine male Caucasian adolescents were studied, aged 13-17 yr. Thirty-eight (48%) of them had a WC above 90th age percentile. All participants were enrolled in one consultation, recording various parameters and collecting one blood sample.

RESULTS

Differences in systolic blood pressure, HDL, high sensitive C-reactive protein, and hemoglobin A1c could be found between groups above or below the 90th WC percentile. Linear regression analysis revealed that WC and BMI-SDS predict traditional risk factors, as well as reduced adiponectin, lower SDF-1, and higher sE-selectin levels. Multiple linear regression analyses show that SDF-1 is in closest correlation to WC and BMI-SDS.

CONCLUSIONS

WC and BMI-SDS predict various alterations of traditional and new cardiovascular risk factors. SDF-1 might be a new marker for diagnosis of obesity-related diseases and help understand pathophysiologic mechanisms.

Authors+Show Affiliations

Clinic of Internal Medicine I, Friedrich-Schiller-University, D-07747 Jena, Germany. christian.jung@med.uni-jena.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19076302

Citation

Jung, Christian, et al. "Association of Waist Circumference, Traditional Cardiovascular Risk Factors, and Stromal-derived Factor-1 in Adolescents." Pediatric Diabetes, vol. 10, no. 5, 2009, pp. 329-35.
Jung C, Fischer N, Fritzenwanger M, et al. Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents. Pediatr Diabetes. 2009;10(5):329-35.
Jung, C., Fischer, N., Fritzenwanger, M., Pernow, J., Brehm, B. R., & Figulla, H. R. (2009). Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents. Pediatric Diabetes, 10(5), 329-35. https://doi.org/10.1111/j.1399-5448.2008.00486.x
Jung C, et al. Association of Waist Circumference, Traditional Cardiovascular Risk Factors, and Stromal-derived Factor-1 in Adolescents. Pediatr Diabetes. 2009;10(5):329-35. PubMed PMID: 19076302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of waist circumference, traditional cardiovascular risk factors, and stromal-derived factor-1 in adolescents. AU - Jung,Christian, AU - Fischer,Nicole, AU - Fritzenwanger,Michael, AU - Pernow,John, AU - Brehm,Bernhard R, AU - Figulla,Hans R, Y1 - 2008/12/05/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/10/29/medline SP - 329 EP - 35 JF - Pediatric diabetes JO - Pediatr Diabetes VL - 10 IS - 5 N2 - BACKGROUND: Overweight and the metabolic syndrome (MS) represent dramatically increasing problems in children and adolescents. Waist circumference (WC) is an important factor to determine MS. So far, WC is a predictor of blood pressure, high-density lipoprotein (HDL), insulin concentration, and visceral fat in adolescents. We investigated whether WC and body mass index standard deviation score (BMI-SDS) are predictors of adiponectin, stromal-derived factor (SDF-1), and soluble E-selectin (sE-selectin) as parameters for beginning insulin resistance and endothelial damage. METHODS: Seventy-nine male Caucasian adolescents were studied, aged 13-17 yr. Thirty-eight (48%) of them had a WC above 90th age percentile. All participants were enrolled in one consultation, recording various parameters and collecting one blood sample. RESULTS: Differences in systolic blood pressure, HDL, high sensitive C-reactive protein, and hemoglobin A1c could be found between groups above or below the 90th WC percentile. Linear regression analysis revealed that WC and BMI-SDS predict traditional risk factors, as well as reduced adiponectin, lower SDF-1, and higher sE-selectin levels. Multiple linear regression analyses show that SDF-1 is in closest correlation to WC and BMI-SDS. CONCLUSIONS: WC and BMI-SDS predict various alterations of traditional and new cardiovascular risk factors. SDF-1 might be a new marker for diagnosis of obesity-related diseases and help understand pathophysiologic mechanisms. SN - 1399-5448 UR - https://www.unboundmedicine.com/medline/citation/19076302/Association_of_waist_circumference_traditional_cardiovascular_risk_factors_and_stromal_derived_factor_1_in_adolescents_ L2 - https://doi.org/10.1111/j.1399-5448.2008.00486.x DB - PRIME DP - Unbound Medicine ER -