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Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris.
Br J Dermatol. 2009 Feb; 160(2):345-52.BJ

Abstract

BACKGROUND

The sebaceous gland exhibits an independent peripheral endocrine function and expresses receptors for neuropeptides. Previous reports have confirmed the presence of a complete corticotropin-releasing hormone (CRH) system in human sebocytes in vitro. The capability of hypothalamic CRH to induce lipid synthesis, induce steroidogenesis and interact with testosterone and growth hormone implicates a possibility of its involvement in the clinical development of acne.

OBJECTIVES

The purpose of the study was to detect expression changes of CRH/CRH binding protein (CRHBP)/CRH receptors (CRHRs) in acne-involved skin, especially in the sebaceous glands.

METHODS

Expression of CRH/CRHBP/CRHRs was analysed by immunohistochemistry in biopsies from facial skin of 33 patients with acne, noninvolved thigh skin of the same patients and normal skin of eight age-matched healthy volunteers.

RESULTS

Very strong positive reaction for CRH was observed in acne-involved skin in all types of sebaceous gland cells, irrespective of their differentiation stage, whereas in noninvolved and normal skin sebaceous glands exhibited a weaker CRH staining depending upon the differentiation stage of sebocytes. The strongest reaction for CRHBP in acne-involved sebaceous glands was in differentiating sebocytes. CRHR-1 and CRHR-2 exhibited the strongest expression in sweat glands and sebaceous glands, respectively.

CONCLUSIONS

Expression of the complete CRH system is abundant in acne-involved skin, especially in the sebaceous glands, possibly activating pathways which affect immune and inflammatory processes leading to the development and stress-induced exacerbation of acne.

Authors+Show Affiliations

Centre of Dermatovenereology, Vilnius University Hospital, Santariskiu Klinikos, Vilnius, Lithuania.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19077080

Citation

Ganceviciene, R, et al. "Involvement of the Corticotropin-releasing Hormone System in the Pathogenesis of Acne Vulgaris." The British Journal of Dermatology, vol. 160, no. 2, 2009, pp. 345-52.
Ganceviciene R, Graziene V, Fimmel S, et al. Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. Br J Dermatol. 2009;160(2):345-52.
Ganceviciene, R., Graziene, V., Fimmel, S., & Zouboulis, C. C. (2009). Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. The British Journal of Dermatology, 160(2), 345-52. https://doi.org/10.1111/j.1365-2133.2008.08959.x
Ganceviciene R, et al. Involvement of the Corticotropin-releasing Hormone System in the Pathogenesis of Acne Vulgaris. Br J Dermatol. 2009;160(2):345-52. PubMed PMID: 19077080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. AU - Ganceviciene,R, AU - Graziene,V, AU - Fimmel,S, AU - Zouboulis,C C, Y1 - 2008/12/10/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/14/medline SP - 345 EP - 52 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 160 IS - 2 N2 - BACKGROUND: The sebaceous gland exhibits an independent peripheral endocrine function and expresses receptors for neuropeptides. Previous reports have confirmed the presence of a complete corticotropin-releasing hormone (CRH) system in human sebocytes in vitro. The capability of hypothalamic CRH to induce lipid synthesis, induce steroidogenesis and interact with testosterone and growth hormone implicates a possibility of its involvement in the clinical development of acne. OBJECTIVES: The purpose of the study was to detect expression changes of CRH/CRH binding protein (CRHBP)/CRH receptors (CRHRs) in acne-involved skin, especially in the sebaceous glands. METHODS: Expression of CRH/CRHBP/CRHRs was analysed by immunohistochemistry in biopsies from facial skin of 33 patients with acne, noninvolved thigh skin of the same patients and normal skin of eight age-matched healthy volunteers. RESULTS: Very strong positive reaction for CRH was observed in acne-involved skin in all types of sebaceous gland cells, irrespective of their differentiation stage, whereas in noninvolved and normal skin sebaceous glands exhibited a weaker CRH staining depending upon the differentiation stage of sebocytes. The strongest reaction for CRHBP in acne-involved sebaceous glands was in differentiating sebocytes. CRHR-1 and CRHR-2 exhibited the strongest expression in sweat glands and sebaceous glands, respectively. CONCLUSIONS: Expression of the complete CRH system is abundant in acne-involved skin, especially in the sebaceous glands, possibly activating pathways which affect immune and inflammatory processes leading to the development and stress-induced exacerbation of acne. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/19077080/Involvement_of_the_corticotropin_releasing_hormone_system_in_the_pathogenesis_of_acne_vulgaris_ L2 - https://doi.org/10.1111/j.1365-2133.2008.08959.x DB - PRIME DP - Unbound Medicine ER -