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Polycystic ovary syndrome: pathophysiology, molecular aspects and clinical implications.
Panminerva Med. 2008 Dec; 50(4):267-78.PM

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age (5-10% prevalence) and the most common cause of anovulatory infertility. A recent consensus has led to the formulation of unifying diagnostic criteria for PCOS. It is multifactorial and polygenic in nature. Although the ovary is central to the pathogenesis of PCOS, however neuroendocrine, ovarian and metabolic dysfunctions play a significant role in the pathophysiology. Short- and long-term consequences of the syndrome have been the focus of much interest. The association of PCOS with hyperandrogenism, hyperinsulinemia and insulin resistance is known and some of the putative molecular aspects are established. Menstrual abnormalities (oligo- or amenorrhea), subfertility, obesity and symptoms of androgen excess are often the main reasons for early referral, whereas diabetes, cardiovascular disease and endometrial cancer represent a clinical finding later in life. It is plausible that appropriate specialist medical management improves the wellbeing of women with PCOS.

Authors+Show Affiliations

Department of Reproductive Medicine, St Mary's Hospital, Manchester, UK. Luciano.Nardo@cmmc.nhs.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19078868

Citation

Nardo, L G., et al. "Polycystic Ovary Syndrome: Pathophysiology, Molecular Aspects and Clinical Implications." Panminerva Medica, vol. 50, no. 4, 2008, pp. 267-78.
Nardo LG, Patchava S, Laing I. Polycystic ovary syndrome: pathophysiology, molecular aspects and clinical implications. Panminerva Med. 2008;50(4):267-78.
Nardo, L. G., Patchava, S., & Laing, I. (2008). Polycystic ovary syndrome: pathophysiology, molecular aspects and clinical implications. Panminerva Medica, 50(4), 267-78.
Nardo LG, Patchava S, Laing I. Polycystic Ovary Syndrome: Pathophysiology, Molecular Aspects and Clinical Implications. Panminerva Med. 2008;50(4):267-78. PubMed PMID: 19078868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome: pathophysiology, molecular aspects and clinical implications. AU - Nardo,L G, AU - Patchava,S, AU - Laing,I, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/16/medline SP - 267 EP - 78 JF - Panminerva medica JO - Panminerva Med VL - 50 IS - 4 N2 - Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age (5-10% prevalence) and the most common cause of anovulatory infertility. A recent consensus has led to the formulation of unifying diagnostic criteria for PCOS. It is multifactorial and polygenic in nature. Although the ovary is central to the pathogenesis of PCOS, however neuroendocrine, ovarian and metabolic dysfunctions play a significant role in the pathophysiology. Short- and long-term consequences of the syndrome have been the focus of much interest. The association of PCOS with hyperandrogenism, hyperinsulinemia and insulin resistance is known and some of the putative molecular aspects are established. Menstrual abnormalities (oligo- or amenorrhea), subfertility, obesity and symptoms of androgen excess are often the main reasons for early referral, whereas diabetes, cardiovascular disease and endometrial cancer represent a clinical finding later in life. It is plausible that appropriate specialist medical management improves the wellbeing of women with PCOS. SN - 0031-0808 UR - https://www.unboundmedicine.com/medline/citation/19078868/Polycystic_ovary_syndrome:_pathophysiology_molecular_aspects_and_clinical_implications_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -