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The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension.
J Hum Hypertens. 2009 Jun; 23(6):402-6.JH

Abstract

To investigate the changes of insulin resistance and soluble intercellular adhesion molecule-1 (sICAM-1) in normotensive adolescents with a family history of hypertension (FH) and to analyse the related factors. The study included 142 normotensive adolescents aged 13-15 years. On the basis of an FH, the samples were divided into positive FH (FH(+) group) and negative FH groups (FH(-) group). Anthropometric measurements included height, weight, waist circumference (WC) and blood pressure (BP). Blood samples were collected and fasting plasma glucose (FPG), serum lipids, true insulin (TI) and sICAM-1 were assayed. The FH(+) group had significantly higher levels of FPG, TI, homeostasis model assessment of insulin resistance (HOMA-IR) and sICAM-1 than the FH(-) group (P<0.01). HOMA-IR showed positive correlation with body mass index (BMI; r=0.405), WC (r=0.416), systolic BP (SBP; r=0.165), FPG (r=0.427), triglyceride (r=0.195), TI (r=0.993) and negative correlation with high density lipoprotein cholesterol (r=-0.196) (P<0.05). sICAM-1 showed a positive correlation with triglyceride (r=0.239, P<0.01). In multiple linear regression analysis, WC (beta=0.024, P=0.000) and FH (beta=0.467, P=0.000) were significant independent predictors for HOMA-IR, and triglyceride (beta=0.328, P=0.007) and FH (beta=0.395, P=0.016) were significant independent predictors for sICAM-1. These results indicate that insulin resistance and endothelial activation were found in normotensive adolescents with an FH. We should make great efforts to alleviate the insulin resistance and endothelial activation by diet and exercise, and it would reduce the incidence of hypertension in adolescents with an FH.

Authors+Show Affiliations

Department of Endocrinology, the First Hospital of Qinhuangdao, Hebei Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19078988

Citation

Fu-zai, Yin, et al. "The Study of Insulin Resistance and Soluble Intercellular Adhesion Molecule-1 in Normotensive Adolescents With a Family History of Hypertension." Journal of Human Hypertension, vol. 23, no. 6, 2009, pp. 402-6.
Fu-zai Y, Qiang L, Shu-yi W, et al. The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension. J Hum Hypertens. 2009;23(6):402-6.
Fu-zai, Y., Qiang, L., Shu-yi, W., Chun-ming, M., Dong-hui, L., Bo-wei, L., & Xiao-li, L. (2009). The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension. Journal of Human Hypertension, 23(6), 402-6. https://doi.org/10.1038/jhh.2008.146
Fu-zai Y, et al. The Study of Insulin Resistance and Soluble Intercellular Adhesion Molecule-1 in Normotensive Adolescents With a Family History of Hypertension. J Hum Hypertens. 2009;23(6):402-6. PubMed PMID: 19078988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension. AU - Fu-zai,Yin, AU - Qiang,Lu, AU - Shu-yi,Wang, AU - Chun-ming,Ma, AU - Dong-hui,Lou, AU - Bo-wei,Liu, AU - Xiao-li,Liu, Y1 - 2008/12/11/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/7/18/medline SP - 402 EP - 6 JF - Journal of human hypertension JO - J Hum Hypertens VL - 23 IS - 6 N2 - To investigate the changes of insulin resistance and soluble intercellular adhesion molecule-1 (sICAM-1) in normotensive adolescents with a family history of hypertension (FH) and to analyse the related factors. The study included 142 normotensive adolescents aged 13-15 years. On the basis of an FH, the samples were divided into positive FH (FH(+) group) and negative FH groups (FH(-) group). Anthropometric measurements included height, weight, waist circumference (WC) and blood pressure (BP). Blood samples were collected and fasting plasma glucose (FPG), serum lipids, true insulin (TI) and sICAM-1 were assayed. The FH(+) group had significantly higher levels of FPG, TI, homeostasis model assessment of insulin resistance (HOMA-IR) and sICAM-1 than the FH(-) group (P<0.01). HOMA-IR showed positive correlation with body mass index (BMI; r=0.405), WC (r=0.416), systolic BP (SBP; r=0.165), FPG (r=0.427), triglyceride (r=0.195), TI (r=0.993) and negative correlation with high density lipoprotein cholesterol (r=-0.196) (P<0.05). sICAM-1 showed a positive correlation with triglyceride (r=0.239, P<0.01). In multiple linear regression analysis, WC (beta=0.024, P=0.000) and FH (beta=0.467, P=0.000) were significant independent predictors for HOMA-IR, and triglyceride (beta=0.328, P=0.007) and FH (beta=0.395, P=0.016) were significant independent predictors for sICAM-1. These results indicate that insulin resistance and endothelial activation were found in normotensive adolescents with an FH. We should make great efforts to alleviate the insulin resistance and endothelial activation by diet and exercise, and it would reduce the incidence of hypertension in adolescents with an FH. SN - 1476-5527 UR - https://www.unboundmedicine.com/medline/citation/19078988/The_study_of_insulin_resistance_and_soluble_intercellular_adhesion_molecule_1_in_normotensive_adolescents_with_a_family_history_of_hypertension_ L2 - https://doi.org/10.1038/jhh.2008.146 DB - PRIME DP - Unbound Medicine ER -