Tags

Type your tag names separated by a space and hit enter

Soya protein reverses dyslipidaemia and the altered capacity of insulin-stimulated glucose utilization in the skeletal muscle of sucrose-rich diet-fed rats.
Br J Nutr. 2009 Jul; 102(1):60-8.BJ

Abstract

The present study investigates the benefits of dietary intake of soya protein upon dyslipidaemia and insulin resistance in rats chronically (8 months) fed a sucrose-rich (63 %) diet (SRD). For this purpose, we analysed the effectiveness of soya protein isolate in improving or reversing these metabolic abnormalities. Wistar rats were fed a SRD for 4 months. By the end of this period, stable dyslipidaemia and insulin resistance were present in the animals. From months 4 to 8, half the animals continued with the SRD and the other half were fed a SRD in which the source of protein casein was substituted by soya. The control group received a diet in which the source of carbohydrate was maize starch. The results showed that: (1) soya protein normalized plasma TAG, cholesterol and NEFA levels in the SRD-fed rats. Moreover, the addition of soya protein reversed the hepatic steatosis. (2) Glucose homeostasis was normalized without changes in circulating insulin levels. Whole-body peripheral insulin sensitivity substantially improved. Besides, soya protein moderately decreases body weight gain limiting the accretion of visceral fat. (3) By shifting the source of dietary protein from casein to soya during the last 4 months of the feeding period it was possible to reverse both the diminished insulin-stimulated glucose oxidation and disposal in the skeletal muscle of SRD-fed rats. This study provides new data showing the beneficial effect of soya protein upon lipid and glucose homeostasis in the experimental model of dyslipidaemia and insulin resistance.

Authors+Show Affiliations

Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria Paraje El Pozo, CC 242 (3000) Santa Fe, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19079840

Citation

Oliva, María E., et al. "Soya Protein Reverses Dyslipidaemia and the Altered Capacity of Insulin-stimulated Glucose Utilization in the Skeletal Muscle of Sucrose-rich Diet-fed Rats." The British Journal of Nutrition, vol. 102, no. 1, 2009, pp. 60-8.
Oliva ME, Chicco AG, Lombardo YB. Soya protein reverses dyslipidaemia and the altered capacity of insulin-stimulated glucose utilization in the skeletal muscle of sucrose-rich diet-fed rats. Br J Nutr. 2009;102(1):60-8.
Oliva, M. E., Chicco, A. G., & Lombardo, Y. B. (2009). Soya protein reverses dyslipidaemia and the altered capacity of insulin-stimulated glucose utilization in the skeletal muscle of sucrose-rich diet-fed rats. The British Journal of Nutrition, 102(1), 60-8. https://doi.org/10.1017/S0007114508159013
Oliva ME, Chicco AG, Lombardo YB. Soya Protein Reverses Dyslipidaemia and the Altered Capacity of Insulin-stimulated Glucose Utilization in the Skeletal Muscle of Sucrose-rich Diet-fed Rats. Br J Nutr. 2009;102(1):60-8. PubMed PMID: 19079840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soya protein reverses dyslipidaemia and the altered capacity of insulin-stimulated glucose utilization in the skeletal muscle of sucrose-rich diet-fed rats. AU - Oliva,María E, AU - Chicco,Adriana G, AU - Lombardo,Yolanda B, Y1 - 2008/12/15/ PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/9/1/medline SP - 60 EP - 8 JF - The British journal of nutrition JO - Br J Nutr VL - 102 IS - 1 N2 - The present study investigates the benefits of dietary intake of soya protein upon dyslipidaemia and insulin resistance in rats chronically (8 months) fed a sucrose-rich (63 %) diet (SRD). For this purpose, we analysed the effectiveness of soya protein isolate in improving or reversing these metabolic abnormalities. Wistar rats were fed a SRD for 4 months. By the end of this period, stable dyslipidaemia and insulin resistance were present in the animals. From months 4 to 8, half the animals continued with the SRD and the other half were fed a SRD in which the source of protein casein was substituted by soya. The control group received a diet in which the source of carbohydrate was maize starch. The results showed that: (1) soya protein normalized plasma TAG, cholesterol and NEFA levels in the SRD-fed rats. Moreover, the addition of soya protein reversed the hepatic steatosis. (2) Glucose homeostasis was normalized without changes in circulating insulin levels. Whole-body peripheral insulin sensitivity substantially improved. Besides, soya protein moderately decreases body weight gain limiting the accretion of visceral fat. (3) By shifting the source of dietary protein from casein to soya during the last 4 months of the feeding period it was possible to reverse both the diminished insulin-stimulated glucose oxidation and disposal in the skeletal muscle of SRD-fed rats. This study provides new data showing the beneficial effect of soya protein upon lipid and glucose homeostasis in the experimental model of dyslipidaemia and insulin resistance. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19079840/Soya_protein_reverses_dyslipidaemia_and_the_altered_capacity_of_insulin_stimulated_glucose_utilization_in_the_skeletal_muscle_of_sucrose_rich_diet_fed_rats_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508159013/type/journal_article DB - PRIME DP - Unbound Medicine ER -