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Intake of dairy products and risk of colorectal neoplasia.
Nutr Res Rev 2008; 21(1):56-67NR

Abstract

Prospective cohort studies suggest that higher intakes of dairy products, in particular milk, are associated with a decreased risk of colorectal cancer (CRC). In Western populations, dairy products are major contributors to dietary Ca, which may have chemopreventive effects in the colon. The pooling of data from prospective studies suggests a significant protective effect of Ca on CRC risk. Randomised controlled trials with Ca supplements have been conducted with both colorectal adenoma and CRC as endpoints. Results suggest that Ca supplementation at a level of 1000-2000 mg/d reduces adenoma recurrence in individuals with a previous adenoma but has no effect on CRC incidence. There is evidence that the risk reduction from dairy foods may not be solely due to their high Ca content. Dairy products contain other potential chemopreventive components such as vitamin D, butyric acid, conjugated linoleic acid, sphingolipids, and probiotic bacteria in fermented products such as yoghurt. The present review will focus on the epidemiological evidence (and in particular prospective cohort studies) investigating the relationship between dairy product consumption and risk of CRC. An outline of the proposed mechanisms responsible for the protective effect of both Ca and other potential chemopreventive components in dairy products will also be presented.

Authors+Show Affiliations

Diet and Gastrointestinal Health Group, Nutritional Sciences Division, King's College London, London, UK. maria.pufulete@kcl.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19079854

Citation

Pufulete, Maria. "Intake of Dairy Products and Risk of Colorectal Neoplasia." Nutrition Research Reviews, vol. 21, no. 1, 2008, pp. 56-67.
Pufulete M. Intake of dairy products and risk of colorectal neoplasia. Nutr Res Rev. 2008;21(1):56-67.
Pufulete, M. (2008). Intake of dairy products and risk of colorectal neoplasia. Nutrition Research Reviews, 21(1), pp. 56-67. doi:10.1017/S0954422408035920.
Pufulete M. Intake of Dairy Products and Risk of Colorectal Neoplasia. Nutr Res Rev. 2008;21(1):56-67. PubMed PMID: 19079854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of dairy products and risk of colorectal neoplasia. A1 - Pufulete,Maria, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/3/7/medline SP - 56 EP - 67 JF - Nutrition research reviews JO - Nutr Res Rev VL - 21 IS - 1 N2 - Prospective cohort studies suggest that higher intakes of dairy products, in particular milk, are associated with a decreased risk of colorectal cancer (CRC). In Western populations, dairy products are major contributors to dietary Ca, which may have chemopreventive effects in the colon. The pooling of data from prospective studies suggests a significant protective effect of Ca on CRC risk. Randomised controlled trials with Ca supplements have been conducted with both colorectal adenoma and CRC as endpoints. Results suggest that Ca supplementation at a level of 1000-2000 mg/d reduces adenoma recurrence in individuals with a previous adenoma but has no effect on CRC incidence. There is evidence that the risk reduction from dairy foods may not be solely due to their high Ca content. Dairy products contain other potential chemopreventive components such as vitamin D, butyric acid, conjugated linoleic acid, sphingolipids, and probiotic bacteria in fermented products such as yoghurt. The present review will focus on the epidemiological evidence (and in particular prospective cohort studies) investigating the relationship between dairy product consumption and risk of CRC. An outline of the proposed mechanisms responsible for the protective effect of both Ca and other potential chemopreventive components in dairy products will also be presented. SN - 1475-2700 UR - https://www.unboundmedicine.com/medline/citation/19079854/Intake_of_dairy_products_and_risk_of_colorectal_neoplasia_ L2 - https://www.cambridge.org/core/product/identifier/S0954422408035920/type/journal_article DB - PRIME DP - Unbound Medicine ER -