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Local excision of ciliary body tumors: a long-term prospective cohort study in China.
Chin Med J (Engl) 2008; 121(21):2152-6CM

Abstract

BACKGROUND

Ciliary body tumors are usually difficult to diagnose and treat in early stages. However, treatment of such tumors has trended toward ocular conservation instead of enucleation. Local excision of ciliary body tumors has become effective with the development of the modern vitrectomy, but long-term outcomes are still not clear. Therefore, we reported the outcome of locally excised ciliary body tumors after long-term follow-up.

METHODS

Twenty-two patients (22 eyes), who had been diagnosed with ciliary body tumors in Beijing Tongren Hospital from January 1996 to June 2001, were enrolled in this prospective cohort study. Localized lamellar sclera-ciliary excisions were performed. In some cases, vitrectomies, scleral graft transplantations, and further excisions of the anterior choroid were performed. Diagnoses were confirmed by histopathologic examination. Patients were followed from five to eleven years after surgery. Their visual acuity, intraocular pressure and local recurrence were recorded with descriptive percentages.

RESULTS

After surgery, all patients maintained normal eyeball appearances. Six patients maintained circular pupils. The final best corrected visual acuities (BCVA) varied from 0.02 - 1.00, including 18 patients (81.82%) who had BCVA equal to or better than that before surgery. Fifteen patients (68.18%) had BCVA better than 0.3. Only two patients had intraocular pressure (IOP) of less than 10 mmHg and the other patients maintained normal IOP. Nine cases (40.91%) were given confirmed diagnosis of malignant melanoma, four (18.18%) of melanocytoma, six (27.27%) of nonpigmented ciliary epithelial adenoma, two (9.09%) of neurofibroma, and one (4.55%) of neurinoma. Twenty patients (90.91%) had no recurrence during the follow-up period. In one case melanocytoma recurred seven years after surgery and enucleation was performed. One patient, whose operation removed a malignant melanoma with a diameter of 16 mm, died of hepatic metastasis five years after the operation.

CONCLUSION

For some ciliary body tumors, especially in the early stages, local excision is an effective and safe method to save the vision and the eyeball.

Authors+Show Affiliations

Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. trweiwenbin@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19080176

Citation

Wei, Wen-bin, et al. "Local Excision of Ciliary Body Tumors: a Long-term Prospective Cohort Study in China." Chinese Medical Journal, vol. 121, no. 21, 2008, pp. 2152-6.
Wei WB, Yang WL, Hu SM, et al. Local excision of ciliary body tumors: a long-term prospective cohort study in China. Chin Med J. 2008;121(21):2152-6.
Wei, W. B., Yang, W. L., Hu, S. M., & Li, B. (2008). Local excision of ciliary body tumors: a long-term prospective cohort study in China. Chinese Medical Journal, 121(21), pp. 2152-6.
Wei WB, et al. Local Excision of Ciliary Body Tumors: a Long-term Prospective Cohort Study in China. Chin Med J. 2008 Nov 5;121(21):2152-6. PubMed PMID: 19080176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local excision of ciliary body tumors: a long-term prospective cohort study in China. AU - Wei,Wen-bin, AU - Yang,Wen-li, AU - Hu,Shi-min, AU - Li,Bin, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/1/7/medline SP - 2152 EP - 6 JF - Chinese medical journal JO - Chin. Med. J. VL - 121 IS - 21 N2 - BACKGROUND: Ciliary body tumors are usually difficult to diagnose and treat in early stages. However, treatment of such tumors has trended toward ocular conservation instead of enucleation. Local excision of ciliary body tumors has become effective with the development of the modern vitrectomy, but long-term outcomes are still not clear. Therefore, we reported the outcome of locally excised ciliary body tumors after long-term follow-up. METHODS: Twenty-two patients (22 eyes), who had been diagnosed with ciliary body tumors in Beijing Tongren Hospital from January 1996 to June 2001, were enrolled in this prospective cohort study. Localized lamellar sclera-ciliary excisions were performed. In some cases, vitrectomies, scleral graft transplantations, and further excisions of the anterior choroid were performed. Diagnoses were confirmed by histopathologic examination. Patients were followed from five to eleven years after surgery. Their visual acuity, intraocular pressure and local recurrence were recorded with descriptive percentages. RESULTS: After surgery, all patients maintained normal eyeball appearances. Six patients maintained circular pupils. The final best corrected visual acuities (BCVA) varied from 0.02 - 1.00, including 18 patients (81.82%) who had BCVA equal to or better than that before surgery. Fifteen patients (68.18%) had BCVA better than 0.3. Only two patients had intraocular pressure (IOP) of less than 10 mmHg and the other patients maintained normal IOP. Nine cases (40.91%) were given confirmed diagnosis of malignant melanoma, four (18.18%) of melanocytoma, six (27.27%) of nonpigmented ciliary epithelial adenoma, two (9.09%) of neurofibroma, and one (4.55%) of neurinoma. Twenty patients (90.91%) had no recurrence during the follow-up period. In one case melanocytoma recurred seven years after surgery and enucleation was performed. One patient, whose operation removed a malignant melanoma with a diameter of 16 mm, died of hepatic metastasis five years after the operation. CONCLUSION: For some ciliary body tumors, especially in the early stages, local excision is an effective and safe method to save the vision and the eyeball. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/19080176/Local_excision_of_ciliary_body_tumors:_a_long_term_prospective_cohort_study_in_China_ L2 - http://Insights.ovid.com/pubmed?pmid=19080176 DB - PRIME DP - Unbound Medicine ER -