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Efficacy and safety of acarbose in the treatment of elderly patients with postprandial hypotension.
Chin Med J (Engl). 2008 Oct 20; 121(20):2054-9.CM

Abstract

BACKGROUND

Postprandial hypotension (PPH) occurs frequently in elderly people and may lead to syncope, falls, dizziness, weakness, angina pectoris, and stroke. Some studies suggest that the magnitude of the postprandial fall in blood pressure (BP) is influenced by the rate at which glucose enters the small intestine. We hypothesized that acarbose (alpha-glucosidase inhibitor), a hypoglycemic agent that decreases the rate of glucose absorption in the small intestine, would attenuate PPH in the elderly, and would be safe in the treatment.

METHODS

Forty-three elderly in-patients with PPH were recruited. All of them were in relatively stable conditions. They had semi-liquid standard meals without and with acarbose for the two following days: screening day and intervention day. Blood pressure and heart rate (HR) were recorded at baseline and every 15 minutes for 120 minutes using a non-invasive ambulatory blood pressure monitoring system during the study, and ejection fraction (EF) and fractional shortening (FS) were measured by two dimensional echocardiography.

RESULTS

Compared with the screening day, the falls in systolic, diastolic and mean arterial blood pressure (SBP, DBP, MAP) (all P < 0.05) were significantly attenuated after taking acarbose during breakfast, so were MAP (P < 0.05) during lunch, DBP (P < 0.05) and MAP (P < 0.05) during supper. The change of HR was not statistically significant after taking acarbose in three meals. EF and FS were positively correlated with the relief rate. The effective power was 63%, and the incidence of adverse drug reaction (ADR) was 9%.

CONCLUSION

Acarbose is effective and safe in the treatment of elderly patients with PPH.

Authors+Show Affiliations

Department of Geriatrics, Second Xiangya Hospital Affiliated to the Central South University, Changsha, Hunan 410011, China. jianzaijin@163.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19080275

Citation

Jian, Zai-jin, and Bai-yu Zhou. "Efficacy and Safety of Acarbose in the Treatment of Elderly Patients With Postprandial Hypotension." Chinese Medical Journal, vol. 121, no. 20, 2008, pp. 2054-9.
Jian ZJ, Zhou BY. Efficacy and safety of acarbose in the treatment of elderly patients with postprandial hypotension. Chin Med J (Engl). 2008;121(20):2054-9.
Jian, Z. J., & Zhou, B. Y. (2008). Efficacy and safety of acarbose in the treatment of elderly patients with postprandial hypotension. Chinese Medical Journal, 121(20), 2054-9.
Jian ZJ, Zhou BY. Efficacy and Safety of Acarbose in the Treatment of Elderly Patients With Postprandial Hypotension. Chin Med J (Engl). 2008 Oct 20;121(20):2054-9. PubMed PMID: 19080275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of acarbose in the treatment of elderly patients with postprandial hypotension. AU - Jian,Zai-jin, AU - Zhou,Bai-yu, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/1/24/medline SP - 2054 EP - 9 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 121 IS - 20 N2 - BACKGROUND: Postprandial hypotension (PPH) occurs frequently in elderly people and may lead to syncope, falls, dizziness, weakness, angina pectoris, and stroke. Some studies suggest that the magnitude of the postprandial fall in blood pressure (BP) is influenced by the rate at which glucose enters the small intestine. We hypothesized that acarbose (alpha-glucosidase inhibitor), a hypoglycemic agent that decreases the rate of glucose absorption in the small intestine, would attenuate PPH in the elderly, and would be safe in the treatment. METHODS: Forty-three elderly in-patients with PPH were recruited. All of them were in relatively stable conditions. They had semi-liquid standard meals without and with acarbose for the two following days: screening day and intervention day. Blood pressure and heart rate (HR) were recorded at baseline and every 15 minutes for 120 minutes using a non-invasive ambulatory blood pressure monitoring system during the study, and ejection fraction (EF) and fractional shortening (FS) were measured by two dimensional echocardiography. RESULTS: Compared with the screening day, the falls in systolic, diastolic and mean arterial blood pressure (SBP, DBP, MAP) (all P < 0.05) were significantly attenuated after taking acarbose during breakfast, so were MAP (P < 0.05) during lunch, DBP (P < 0.05) and MAP (P < 0.05) during supper. The change of HR was not statistically significant after taking acarbose in three meals. EF and FS were positively correlated with the relief rate. The effective power was 63%, and the incidence of adverse drug reaction (ADR) was 9%. CONCLUSION: Acarbose is effective and safe in the treatment of elderly patients with PPH. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/19080275/Efficacy_and_safety_of_acarbose_in_the_treatment_of_elderly_patients_with_postprandial_hypotension_ L2 - https://Insights.ovid.com/pubmed?pmid=19080275 DB - PRIME DP - Unbound Medicine ER -