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[The role of CD4+CD25+ regulatory T cells in the pathogenesis of chronic abacterial prostatitis/chronic pelvic pain syndrome].
Zhonghua Yi Xue Za Zhi. 2008 Nov 04; 88(40):2838-41.ZY

Abstract

OBJECTIVE

To explore the role of CD4+CD25+ regulatory T cells in the pathogenesis of chronic abacterial prostatitis/chronic pelvic pain syndrome (CAP/CPPS).

METHODS

Peripheral blood samples were collected from 45 CAP/CPPS patients and 18 healthy age-matched male persons. Peripheral blood mononuclear cells (PBMCs) were isolated. The percentages of CD4+CD25+ and CD4+CD25high regulatory T cells were detected by flow cytometry. PCR was used to examine the mRNA expression of Foxp3, a transcription factor expressed in the CD4+CD25+ cells. ELISA was used to examine the plasma level of tumor growth factor (TGF)-beta1.

RESULTS

There were no significant differences in the percentages of peripheral blood CD4+CD25+ and CD4+CD25highT cells between the CAP/CPPS patients and normal control group (both P>0.05). The Foxp3 mRNA in the PBMCs of the CAP/CPPS IIIA and CAP/CPPS IIIB patients were (0.69+/-0.23) and (0.44+/-0.18) respectively, both significantly lower than that of the control group [(1.37+/-0.19), P<0.05]. The serum TGF-beta1 levels of the CAP/CPPS IIIA and CAP/CPPS IIIB patients were (18.09+/-10.45) pg/ml and (14.06+/-6.22) pg/ml respectively, both significantly lower than that of the control group [(27.01+/-13.29) pg/ml, both P<0.05].

CONCLUSION

Not the number of peripheral blood CD4+CD25+ regulatory T cells, but its defective function participates in the pathogenesis of CAP/CPPS. The Foxp3 gene and TGF-beta1 play important roles in the process of pathogenesis of CAP/CPPS too.

Authors+Show Affiliations

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. gwangtjm@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19080493

Citation

Wang, Shao-gang, et al. "[The Role of CD4+CD25+ Regulatory T Cells in the Pathogenesis of Chronic Abacterial Prostatitis/chronic Pelvic Pain Syndrome]." Zhonghua Yi Xue Za Zhi, vol. 88, no. 40, 2008, pp. 2838-41.
Wang SG, Bai J, Xi QL, et al. [The role of CD4+CD25+ regulatory T cells in the pathogenesis of chronic abacterial prostatitis/chronic pelvic pain syndrome]. Zhonghua Yi Xue Za Zhi. 2008;88(40):2838-41.
Wang, S. G., Bai, J., Xi, Q. L., Hu, D. L., Liu, J. H., & Ye, Z. Q. (2008). [The role of CD4+CD25+ regulatory T cells in the pathogenesis of chronic abacterial prostatitis/chronic pelvic pain syndrome]. Zhonghua Yi Xue Za Zhi, 88(40), 2838-41.
Wang SG, et al. [The Role of CD4+CD25+ Regulatory T Cells in the Pathogenesis of Chronic Abacterial Prostatitis/chronic Pelvic Pain Syndrome]. Zhonghua Yi Xue Za Zhi. 2008 Nov 4;88(40):2838-41. PubMed PMID: 19080493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of CD4+CD25+ regulatory T cells in the pathogenesis of chronic abacterial prostatitis/chronic pelvic pain syndrome]. AU - Wang,Shao-gang, AU - Bai,Jian, AU - Xi,Qi-lin, AU - Hu,Dong-liang, AU - Liu,Ji-hong, AU - Ye,Zhang-qun, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/5/29/medline SP - 2838 EP - 41 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 88 IS - 40 N2 - OBJECTIVE: To explore the role of CD4+CD25+ regulatory T cells in the pathogenesis of chronic abacterial prostatitis/chronic pelvic pain syndrome (CAP/CPPS). METHODS: Peripheral blood samples were collected from 45 CAP/CPPS patients and 18 healthy age-matched male persons. Peripheral blood mononuclear cells (PBMCs) were isolated. The percentages of CD4+CD25+ and CD4+CD25high regulatory T cells were detected by flow cytometry. PCR was used to examine the mRNA expression of Foxp3, a transcription factor expressed in the CD4+CD25+ cells. ELISA was used to examine the plasma level of tumor growth factor (TGF)-beta1. RESULTS: There were no significant differences in the percentages of peripheral blood CD4+CD25+ and CD4+CD25highT cells between the CAP/CPPS patients and normal control group (both P>0.05). The Foxp3 mRNA in the PBMCs of the CAP/CPPS IIIA and CAP/CPPS IIIB patients were (0.69+/-0.23) and (0.44+/-0.18) respectively, both significantly lower than that of the control group [(1.37+/-0.19), P<0.05]. The serum TGF-beta1 levels of the CAP/CPPS IIIA and CAP/CPPS IIIB patients were (18.09+/-10.45) pg/ml and (14.06+/-6.22) pg/ml respectively, both significantly lower than that of the control group [(27.01+/-13.29) pg/ml, both P<0.05]. CONCLUSION: Not the number of peripheral blood CD4+CD25+ regulatory T cells, but its defective function participates in the pathogenesis of CAP/CPPS. The Foxp3 gene and TGF-beta1 play important roles in the process of pathogenesis of CAP/CPPS too. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/19080493/[The_role_of_CD4+CD25+_regulatory_T_cells_in_the_pathogenesis_of_chronic_abacterial_prostatitis/chronic_pelvic_pain_syndrome]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2008&amp;vol=88&amp;issue=40&amp;fpage=2838 DB - PRIME DP - Unbound Medicine ER -