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[Relation of vascular endothelial growth factor-D expression to microvessel density, microlymphatic vessel density, and lymph-node metastasis of lung adenocarcinoma].
Zhonghua Yi Xue Za Zhi. 2008 Aug 12; 88(31):2179-82.ZY

Abstract

OBJECTIVE

To investigate the relationship of expression of vascular endothelial growth factor (VEGF)-D to microvessel density (MVD), microlymphatic vessel density (MLVD), and lymph node metastasis in lung adenocarcinoma.

METHODS

Fresh specimens of lung adenocarcinoma were collected form 48 patients with lung adenocarcinoma, 28 males and 20 females, aged 35 - 78, during operation. Semi-quantitative RT-PCR was used to detect the mRNA expression of VEGF-D, and immunohistochemistry was used to detect the protein expression of VEGF-D, CD34 (marker of MVD), and VEGF receptor (VEGFR)-3 (marker of MLV).

RESULTS

The expression of VEGF-D mRNA in the lung cancer was significantly higher than that in the normal lung tissue, and the expression of VEGF-D protein in the cancerous invasive edge was significantly higher than that in the center of cancerous tissues. Twenty-one of the 29 lung adenocarcinoma patients at stages III - IV were VEGF-D positive, a proportion significantly higher than that of the patients at stages I - II (7/19, P = 0.015). The MLVD of the VEGF-D positive group was 10.25 +/- 2.50, significantly higher than that of the VEGF-D negative group (6.8 +/- 2.2, P < 0.01). Twenty-three of the 28 VEGF-D positive patients showed lymph node metastasis, a proportion significantly higher than that of the VEGF-D negative group (9/20, P = 0.012).

CONCLUSION

VEGF-D is related with the lymphangiogenesis and lymph node metastasis in lung adenocarcinoma, but not with angiogenesis.

Authors+Show Affiliations

Department of Thoracic Surgery, Second Affiliated Hospital of Medical College of Shandong University, Jinan 250033, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19080666

Citation

Cong, Bo, et al. "[Relation of Vascular Endothelial Growth factor-D Expression to Microvessel Density, Microlymphatic Vessel Density, and Lymph-node Metastasis of Lung Adenocarcinoma]." Zhonghua Yi Xue Za Zhi, vol. 88, no. 31, 2008, pp. 2179-82.
Cong B, Zhao X, Zhao XG, et al. [Relation of vascular endothelial growth factor-D expression to microvessel density, microlymphatic vessel density, and lymph-node metastasis of lung adenocarcinoma]. Zhonghua Yi Xue Za Zhi. 2008;88(31):2179-82.
Cong, B., Zhao, X., Zhao, X. G., Dong, X. P., & Peng, C. L. (2008). [Relation of vascular endothelial growth factor-D expression to microvessel density, microlymphatic vessel density, and lymph-node metastasis of lung adenocarcinoma]. Zhonghua Yi Xue Za Zhi, 88(31), 2179-82.
Cong B, et al. [Relation of Vascular Endothelial Growth factor-D Expression to Microvessel Density, Microlymphatic Vessel Density, and Lymph-node Metastasis of Lung Adenocarcinoma]. Zhonghua Yi Xue Za Zhi. 2008 Aug 12;88(31):2179-82. PubMed PMID: 19080666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relation of vascular endothelial growth factor-D expression to microvessel density, microlymphatic vessel density, and lymph-node metastasis of lung adenocarcinoma]. AU - Cong,Bo, AU - Zhao,Xin, AU - Zhao,Xiao-gang, AU - Dong,Xiao-peng, AU - Peng,Chuan-liang, PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/4/10/medline SP - 2179 EP - 82 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 88 IS - 31 N2 - OBJECTIVE: To investigate the relationship of expression of vascular endothelial growth factor (VEGF)-D to microvessel density (MVD), microlymphatic vessel density (MLVD), and lymph node metastasis in lung adenocarcinoma. METHODS: Fresh specimens of lung adenocarcinoma were collected form 48 patients with lung adenocarcinoma, 28 males and 20 females, aged 35 - 78, during operation. Semi-quantitative RT-PCR was used to detect the mRNA expression of VEGF-D, and immunohistochemistry was used to detect the protein expression of VEGF-D, CD34 (marker of MVD), and VEGF receptor (VEGFR)-3 (marker of MLV). RESULTS: The expression of VEGF-D mRNA in the lung cancer was significantly higher than that in the normal lung tissue, and the expression of VEGF-D protein in the cancerous invasive edge was significantly higher than that in the center of cancerous tissues. Twenty-one of the 29 lung adenocarcinoma patients at stages III - IV were VEGF-D positive, a proportion significantly higher than that of the patients at stages I - II (7/19, P = 0.015). The MLVD of the VEGF-D positive group was 10.25 +/- 2.50, significantly higher than that of the VEGF-D negative group (6.8 +/- 2.2, P < 0.01). Twenty-three of the 28 VEGF-D positive patients showed lymph node metastasis, a proportion significantly higher than that of the VEGF-D negative group (9/20, P = 0.012). CONCLUSION: VEGF-D is related with the lymphangiogenesis and lymph node metastasis in lung adenocarcinoma, but not with angiogenesis. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/19080666/[Relation_of_vascular_endothelial_growth_factor_D_expression_to_microvessel_density_microlymphatic_vessel_density_and_lymph_node_metastasis_of_lung_adenocarcinoma]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2008&amp;vol=88&amp;issue=31&amp;fpage=2179 DB - PRIME DP - Unbound Medicine ER -