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Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan.
Environ Res. 2009 Feb; 109(2):175-80.ER

Abstract

Limited data are available on the background levels of exposure to synthetic pyrethroid (PYR) in Japan, despite their frequent application for agriculture and indoor extermination and possible effects of chronic and/or low-dose PYR exposure on human health. This study was conducted to describe the level and distribution of one of the major PYR metabolites, 3-phenoxybenzoic acid (3-PBA), in urine samples collected from a general population in Japan. The subjects were 535 individuals (184 men and 351 women; 61.5+/-9.8 years of age, mean+/-S.D.) residing in a town in Hokkaido, a dairy and agricultural area. Urinary 3-PBA was found detectable in 98% of samples above the limit of detection of 0.02 microg/l. The geometric mean values of urinary 3-PBA in occupationally exposed farmers (n=87) and the remaining general group without occupational exposure (n=448) were 0.38 and 0.29 microg/l, respectively, ranging from <LOD to 17.09 microg/l. No significant differences in urinary 3-PBA concentrations were shown between these two groups. Moreover, 3-PBA concentrations were found comparable to those reported in some countries. The present study is, to our knowledge, the first report of a biological monitoring study of urinary 3-PBA, which elucidated the background environmental exposure level of PYR in the Japanese general population without occupational exposure. Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan.

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Authors+Show Affiliations

Ueyama J
Program in Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461-8673, Japan. ueyama@met.nagoya-u.ac.jp
Kimata A
No affiliation info available
Kamijima M
No affiliation info available
Hamajima N
No affiliation info available
Ito Y
No affiliation info available
Suzuki K
No affiliation info available
Inoue T
No affiliation info available
Yamamoto K
No affiliation info available
Takagi K
No affiliation info available
Saito I
No affiliation info available
Miyamoto K
No affiliation info available
Hasegawa T
No affiliation info available
Kondo T
No affiliation info available

MeSH

AdultAgedBenzoatesCreatinineEnvironmental ExposureEnvironmental MonitoringFemaleGas Chromatography-Mass SpectrometryHumansInsecticidesJapanMaleMiddle AgedOccupational ExposurePyrethrinsRural HealthSurveys and QuestionnairesYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19081088

Citation

Ueyama, Jun, et al. "Urinary Excretion of 3-phenoxybenzoic Acid in Middle-aged and Elderly General Population of Japan." Environmental Research, vol. 109, no. 2, 2009, pp. 175-80.
Ueyama J, Kimata A, Kamijima M, et al. Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan. Environ Res. 2009;109(2):175-80.
Ueyama, J., Kimata, A., Kamijima, M., Hamajima, N., Ito, Y., Suzuki, K., Inoue, T., Yamamoto, K., Takagi, K., Saito, I., Miyamoto, K., Hasegawa, T., & Kondo, T. (2009). Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan. Environmental Research, 109(2), 175-80. https://doi.org/10.1016/j.envres.2008.09.006
Ueyama J, et al. Urinary Excretion of 3-phenoxybenzoic Acid in Middle-aged and Elderly General Population of Japan. Environ Res. 2009;109(2):175-80. PubMed PMID: 19081088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan. AU - Ueyama,Jun, AU - Kimata,Akiko, AU - Kamijima,Michihiro, AU - Hamajima,Nobuyuki, AU - Ito,Yoshinori, AU - Suzuki,Koji, AU - Inoue,Takashi, AU - Yamamoto,Kanami, AU - Takagi,Kenji, AU - Saito,Isao, AU - Miyamoto,Ken-ichi, AU - Hasegawa,Takaaki, AU - Kondo,Takaaki, Y1 - 2008/12/09/ PY - 2008/06/30/received PY - 2008/09/22/revised PY - 2008/09/29/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/2/14/medline SP - 175 EP - 80 JF - Environmental research JO - Environ Res VL - 109 IS - 2 N2 - Limited data are available on the background levels of exposure to synthetic pyrethroid (PYR) in Japan, despite their frequent application for agriculture and indoor extermination and possible effects of chronic and/or low-dose PYR exposure on human health. This study was conducted to describe the level and distribution of one of the major PYR metabolites, 3-phenoxybenzoic acid (3-PBA), in urine samples collected from a general population in Japan. The subjects were 535 individuals (184 men and 351 women; 61.5+/-9.8 years of age, mean+/-S.D.) residing in a town in Hokkaido, a dairy and agricultural area. Urinary 3-PBA was found detectable in 98% of samples above the limit of detection of 0.02 microg/l. The geometric mean values of urinary 3-PBA in occupationally exposed farmers (n=87) and the remaining general group without occupational exposure (n=448) were 0.38 and 0.29 microg/l, respectively, ranging from <LOD to 17.09 microg/l. No significant differences in urinary 3-PBA concentrations were shown between these two groups. Moreover, 3-PBA concentrations were found comparable to those reported in some countries. The present study is, to our knowledge, the first report of a biological monitoring study of urinary 3-PBA, which elucidated the background environmental exposure level of PYR in the Japanese general population without occupational exposure. Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/19081088/Urinary_excretion_of_3_phenoxybenzoic_acid_in_middle_aged_and_elderly_general_population_of_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(08)00243-0 DB - PRIME DP - Unbound Medicine ER -