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Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans.
Environ Pollut. 2009 Apr; 157(4):1171-7.EP

Abstract

Limited information is available on the environmental behavior and associated potential risk of manufactured oxide nanoparticles (NPs). In this research, toxicity of nanoparticulate and bulk ZnO, Al(2)O(3) and TiO(2) were examined to the nematode Caenorhabditis elegans with Escherichia coli as a food source. Parallel experiments with dissolved metal ions from NPs were also conducted. The 24-h median lethal concentration (LC(50)) and sublethal endpoints were assessed. Both NPs and their bulk counterparts were toxic, inhibiting growth and especially the reproductive capability of the nematode. The 24-h LC(50) for ZnO NPs (2.3 mg L(-1)) and bulk ZnO was not significantly different, but significantly different between Al(2)O(3) NPs (82 mg L(-1)) and bulk Al(2)O(3) (153 mg L(-1)), and between TiO(2) NPs (80 mg L(-1)) and bulk TiO(2) (136 mg L(-1)). Oxide solubility influenced the toxicity of ZnO and Al(2)O(3) NPs, but nanoparticle-dependent toxicity was indeed observed for the investigated NPs.

Authors+Show Affiliations

Department of Plant, Soil and Insect Sciences, University of Massachusetts, Stockbridge Hall, Amherst, MA 01003, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19081167

Citation

Wang, Huanhua, et al. "Toxicity of Nanoparticulate and Bulk ZnO, Al2O3 and TiO2 to the Nematode Caenorhabditis Elegans." Environmental Pollution (Barking, Essex : 1987), vol. 157, no. 4, 2009, pp. 1171-7.
Wang H, Wick RL, Xing B. Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans. Environ Pollut. 2009;157(4):1171-7.
Wang, H., Wick, R. L., & Xing, B. (2009). Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans. Environmental Pollution (Barking, Essex : 1987), 157(4), 1171-7. https://doi.org/10.1016/j.envpol.2008.11.004
Wang H, Wick RL, Xing B. Toxicity of Nanoparticulate and Bulk ZnO, Al2O3 and TiO2 to the Nematode Caenorhabditis Elegans. Environ Pollut. 2009;157(4):1171-7. PubMed PMID: 19081167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans. AU - Wang,Huanhua, AU - Wick,Robert L, AU - Xing,Baoshan, Y1 - 2008/12/09/ PY - 2008/08/06/received PY - 2008/10/30/revised PY - 2008/11/03/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/5/15/medline SP - 1171 EP - 7 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 157 IS - 4 N2 - Limited information is available on the environmental behavior and associated potential risk of manufactured oxide nanoparticles (NPs). In this research, toxicity of nanoparticulate and bulk ZnO, Al(2)O(3) and TiO(2) were examined to the nematode Caenorhabditis elegans with Escherichia coli as a food source. Parallel experiments with dissolved metal ions from NPs were also conducted. The 24-h median lethal concentration (LC(50)) and sublethal endpoints were assessed. Both NPs and their bulk counterparts were toxic, inhibiting growth and especially the reproductive capability of the nematode. The 24-h LC(50) for ZnO NPs (2.3 mg L(-1)) and bulk ZnO was not significantly different, but significantly different between Al(2)O(3) NPs (82 mg L(-1)) and bulk Al(2)O(3) (153 mg L(-1)), and between TiO(2) NPs (80 mg L(-1)) and bulk TiO(2) (136 mg L(-1)). Oxide solubility influenced the toxicity of ZnO and Al(2)O(3) NPs, but nanoparticle-dependent toxicity was indeed observed for the investigated NPs. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/19081167/Toxicity_of_nanoparticulate_and_bulk_ZnO_Al2O3_and_TiO2_to_the_nematode_Caenorhabditis_elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(08)00590-3 DB - PRIME DP - Unbound Medicine ER -