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Perturbation of phospholipid and triacylglycerol fatty acid positional location in the heart of rats depleted of n-3 long-chain polyunsaturates.
Nutr Res. 2008 Jan; 28(1):51-7.NR

Abstract

Rats depleted of long-chain polyunsaturated n-3 fatty acids (n-3-D) display several features of the metabolic syndrome, including obesity, liver steatosis, insulin resistance, hypertension, and cardiac hypertrophy. In this study, the heart phospholipid (PL) and triacylglycerol (TG) fatty acid content and pattern were compared between female control rats (C) and n-3-D rats. The sole n-3 fatty acids found in n-3-D rats, C22:5(n-3) and C22:6(n-3), were 10 to 20 times lower than in C. The total fatty acid content of PL was lower in n-3-D rats than C. No ectopic TG accumulation was found in n-3-D rats. In both PL and TG, the C16:0/C16:1(n-7) and C18:0/C18:1(n-9) ratios suggested increased Delta9-desaturase activity in n-3-D rats. The PL C18:2(n-6)/C20:4(n-6) and C20:4(n-6)/C22:4(n-6) ratios were also lower in n-3-D rats than C. Prior intravenous injection of a medium-chain TG:fish oil emulsion to n-3-D rats 60 to 120 minutes before killing augmented the PL content in C22:5(n-3) and C22:6(n-3), minimized the age-related decrease in the PL C18:1(n-9) relative content, and increased the TG C22:4(n-6) content. The alteration of cardiac function in n-3-D rats and its improvement after injection of medium-chain TG:fish oil emulsion coincides with parallel changes in heart lipid fatty acid content and pattern.

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Authors+Show Affiliations

Portois L
Laboratory of Experimental Surgery, Brussels Free University, B-1070 Brussels, Belgium.
Peltier S
No affiliation info available
Sener A
No affiliation info available
Malaisse WJ
No affiliation info available
Carpentier YA
No affiliation info available

MeSH

AnimalsFatty Acids, Omega-3FemaleHeartInjections, IntravenousMyocardiumPhospholipidsRandom AllocationRatsStearoyl-CoA DesaturaseTriglycerides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19083388

Citation

Portois, Laurence, et al. "Perturbation of Phospholipid and Triacylglycerol Fatty Acid Positional Location in the Heart of Rats Depleted of N-3 Long-chain Polyunsaturates." Nutrition Research (New York, N.Y.), vol. 28, no. 1, 2008, pp. 51-7.
Portois L, Peltier S, Sener A, et al. Perturbation of phospholipid and triacylglycerol fatty acid positional location in the heart of rats depleted of n-3 long-chain polyunsaturates. Nutr Res. 2008;28(1):51-7.
Portois, L., Peltier, S., Sener, A., Malaisse, W. J., & Carpentier, Y. A. (2008). Perturbation of phospholipid and triacylglycerol fatty acid positional location in the heart of rats depleted of n-3 long-chain polyunsaturates. Nutrition Research (New York, N.Y.), 28(1), 51-7. https://doi.org/10.1016/j.nutres.2007.11.006
Portois L, et al. Perturbation of Phospholipid and Triacylglycerol Fatty Acid Positional Location in the Heart of Rats Depleted of N-3 Long-chain Polyunsaturates. Nutr Res. 2008;28(1):51-7. PubMed PMID: 19083388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perturbation of phospholipid and triacylglycerol fatty acid positional location in the heart of rats depleted of n-3 long-chain polyunsaturates. AU - Portois,Laurence, AU - Peltier,Sébastien, AU - Sener,Abdullah, AU - Malaisse,Willy J, AU - Carpentier,Yvon A, PY - 2007/07/16/received PY - 2007/11/19/revised PY - 2007/11/19/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/3/7/medline SP - 51 EP - 7 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 28 IS - 1 N2 - Rats depleted of long-chain polyunsaturated n-3 fatty acids (n-3-D) display several features of the metabolic syndrome, including obesity, liver steatosis, insulin resistance, hypertension, and cardiac hypertrophy. In this study, the heart phospholipid (PL) and triacylglycerol (TG) fatty acid content and pattern were compared between female control rats (C) and n-3-D rats. The sole n-3 fatty acids found in n-3-D rats, C22:5(n-3) and C22:6(n-3), were 10 to 20 times lower than in C. The total fatty acid content of PL was lower in n-3-D rats than C. No ectopic TG accumulation was found in n-3-D rats. In both PL and TG, the C16:0/C16:1(n-7) and C18:0/C18:1(n-9) ratios suggested increased Delta9-desaturase activity in n-3-D rats. The PL C18:2(n-6)/C20:4(n-6) and C20:4(n-6)/C22:4(n-6) ratios were also lower in n-3-D rats than C. Prior intravenous injection of a medium-chain TG:fish oil emulsion to n-3-D rats 60 to 120 minutes before killing augmented the PL content in C22:5(n-3) and C22:6(n-3), minimized the age-related decrease in the PL C18:1(n-9) relative content, and increased the TG C22:4(n-6) content. The alteration of cardiac function in n-3-D rats and its improvement after injection of medium-chain TG:fish oil emulsion coincides with parallel changes in heart lipid fatty acid content and pattern. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19083388/Perturbation_of_phospholipid_and_triacylglycerol_fatty_acid_positional_location_in_the_heart_of_rats_depleted_of_n_3_long_chain_polyunsaturates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(07)00279-5 DB - PRIME DP - Unbound Medicine ER -
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