Tags

Type your tag names separated by a space and hit enter

Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats.
Nutr Res. 2008 Feb; 28(2):113-21.NR

Abstract

The importance of nutritional supplementation in diabetes remains an unresolved issue. The present study was undertaken to examine the effects of alpha-tocopherol and CoQ(10), powerful antioxidants, on metabolic control and on the pancreatic mitochondria of GK rats, a model of type 2 diabetes. We also evaluated the efficacy of these nutrients in preventing the diabetic pancreatic lesions observed in GK rats. Rats were divided into 4 groups, a control group of diabetic GK rats and 3 groups of GK rats administered with alpha-tocopherol and CoQ(10) alone or both in association, during 8 weeks. Fasting blood glucose levels were not significantly different between the groups, nor were blood glucose levels at 2 hours after a glucose load. HbA1c level was significantly reduced in the group supplemented with both antioxidants. Diabetes induced a decrease in coenzyme Q plasma levels that prevailed after treatment with antioxidants. In addition, the plasma alpha-tocopherol levels were higher after treatment with the antioxidants. An increment in some components of the antioxidant defense system was observed in pancreatic mitochondria of treated GK rats. Moreover, the antioxidants tested either alone or in association failed to prevent the pancreatic lesions in this animal model of type 2 diabetes. In conclusion, our results indicate that CoQ(10) and alpha-tocopherol decrease glycated HbA1c and pancreatic lipid peroxidation. These antioxidants increase some components of the antioxidant defense system but do not prevent pancreatic lesions. Thus, we cannot rule out the potential benefit of antioxidant treatments in type 2 diabetes in the prevention of their complications.

Authors+Show Affiliations

Institute of Physiology, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal. csena@ci.uc.ptNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19083397

Citation

Sena, Cristina M., et al. "Supplementation of Coenzyme Q10 and Alpha-tocopherol Lowers Glycated Hemoglobin Level and Lipid Peroxidation in Pancreas of Diabetic Rats." Nutrition Research (New York, N.Y.), vol. 28, no. 2, 2008, pp. 113-21.
Sena CM, Nunes E, Gomes A, et al. Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats. Nutr Res. 2008;28(2):113-21.
Sena, C. M., Nunes, E., Gomes, A., Santos, M. S., Proença, T., Martins, M. I., & Seiça, R. M. (2008). Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats. Nutrition Research (New York, N.Y.), 28(2), 113-21. https://doi.org/10.1016/j.nutres.2007.12.005
Sena CM, et al. Supplementation of Coenzyme Q10 and Alpha-tocopherol Lowers Glycated Hemoglobin Level and Lipid Peroxidation in Pancreas of Diabetic Rats. Nutr Res. 2008;28(2):113-21. PubMed PMID: 19083397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats. AU - Sena,Cristina M, AU - Nunes,Elsa, AU - Gomes,Aline, AU - Santos,Maria S, AU - Proença,Teresa, AU - Martins,Maria I, AU - Seiça,Raquel M, PY - 2007/05/02/received PY - 2007/11/27/revised PY - 2007/12/02/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/3/7/medline SP - 113 EP - 21 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 28 IS - 2 N2 - The importance of nutritional supplementation in diabetes remains an unresolved issue. The present study was undertaken to examine the effects of alpha-tocopherol and CoQ(10), powerful antioxidants, on metabolic control and on the pancreatic mitochondria of GK rats, a model of type 2 diabetes. We also evaluated the efficacy of these nutrients in preventing the diabetic pancreatic lesions observed in GK rats. Rats were divided into 4 groups, a control group of diabetic GK rats and 3 groups of GK rats administered with alpha-tocopherol and CoQ(10) alone or both in association, during 8 weeks. Fasting blood glucose levels were not significantly different between the groups, nor were blood glucose levels at 2 hours after a glucose load. HbA1c level was significantly reduced in the group supplemented with both antioxidants. Diabetes induced a decrease in coenzyme Q plasma levels that prevailed after treatment with antioxidants. In addition, the plasma alpha-tocopherol levels were higher after treatment with the antioxidants. An increment in some components of the antioxidant defense system was observed in pancreatic mitochondria of treated GK rats. Moreover, the antioxidants tested either alone or in association failed to prevent the pancreatic lesions in this animal model of type 2 diabetes. In conclusion, our results indicate that CoQ(10) and alpha-tocopherol decrease glycated HbA1c and pancreatic lipid peroxidation. These antioxidants increase some components of the antioxidant defense system but do not prevent pancreatic lesions. Thus, we cannot rule out the potential benefit of antioxidant treatments in type 2 diabetes in the prevention of their complications. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19083397/Supplementation_of_coenzyme_Q10_and_alpha_tocopherol_lowers_glycated_hemoglobin_level_and_lipid_peroxidation_in_pancreas_of_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(07)00286-2 DB - PRIME DP - Unbound Medicine ER -