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The combination of alpha-lipoic acid supplementation and aerobic exercise inhibits lipid peroxidation in rat skeletal muscles.
Nutr Res. 2008 Jun; 28(6):399-405.NR

Abstract

We investigated the effect of DL-alpha-lipoic acid (LA) supplementation and regular aerobic exercise on the concentrations of malondialdehyde (MDA) and vitamin E, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and the levels of glutathione (GSH) in rat skeletal muscles (soleus and red gastrocnemius). For 8 weeks, rats (n = 7 per group) were (1) exercised on a treadmill for 30 min d(-1), (2) treated with supplemental LA, or (3) exercised and treated with supplemental LA. Control rats (n = 7) did not receive LA and were not exercised. DL-alpha-lipoic acid (100 mg kg(-1)) was administered daily as an oral supplement. The rats were exercised in a graded manner for 5 d wk(-1). The concentration of MDA in the soleus and red gastrocnemius was significantly lower in rats that exercised and received LA than in the other groups. Compared with the other groups, rats that exercised and received LA had a significantly higher vitamin E concentration in the soleus. The SOD and GPx activities in the soleus and red gastrocnemius were significantly higher in rats that exercised and received LA. These results suggest that LA supplementation combined with aerobic treadmill exercise inhibits lipid peroxidation in skeletal muscles. This effect was especially remarkable in the soleus, which is particularly sensitive to oxidative stress, as revealed by the increased vitamin E level and SOD and GPx activities.

Authors+Show Affiliations

School of Sport Science, Sungkyunkwan University, Chunchun-dong, Jangan-gu, Suwon 440-746, South Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19083438

Citation

Chae, Chang-Hun, et al. "The Combination of Alpha-lipoic Acid Supplementation and Aerobic Exercise Inhibits Lipid Peroxidation in Rat Skeletal Muscles." Nutrition Research (New York, N.Y.), vol. 28, no. 6, 2008, pp. 399-405.
Chae CH, Shin CH, Kim HT. The combination of alpha-lipoic acid supplementation and aerobic exercise inhibits lipid peroxidation in rat skeletal muscles. Nutr Res. 2008;28(6):399-405.
Chae, C. H., Shin, C. H., & Kim, H. T. (2008). The combination of alpha-lipoic acid supplementation and aerobic exercise inhibits lipid peroxidation in rat skeletal muscles. Nutrition Research (New York, N.Y.), 28(6), 399-405. https://doi.org/10.1016/j.nutres.2008.02.010
Chae CH, Shin CH, Kim HT. The Combination of Alpha-lipoic Acid Supplementation and Aerobic Exercise Inhibits Lipid Peroxidation in Rat Skeletal Muscles. Nutr Res. 2008;28(6):399-405. PubMed PMID: 19083438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The combination of alpha-lipoic acid supplementation and aerobic exercise inhibits lipid peroxidation in rat skeletal muscles. AU - Chae,Chang-Hun, AU - Shin,Chul-Ho, AU - Kim,Hyun-Tae, PY - 2007/10/02/received PY - 2008/01/03/revised PY - 2008/02/08/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/3/5/medline SP - 399 EP - 405 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 28 IS - 6 N2 - We investigated the effect of DL-alpha-lipoic acid (LA) supplementation and regular aerobic exercise on the concentrations of malondialdehyde (MDA) and vitamin E, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and the levels of glutathione (GSH) in rat skeletal muscles (soleus and red gastrocnemius). For 8 weeks, rats (n = 7 per group) were (1) exercised on a treadmill for 30 min d(-1), (2) treated with supplemental LA, or (3) exercised and treated with supplemental LA. Control rats (n = 7) did not receive LA and were not exercised. DL-alpha-lipoic acid (100 mg kg(-1)) was administered daily as an oral supplement. The rats were exercised in a graded manner for 5 d wk(-1). The concentration of MDA in the soleus and red gastrocnemius was significantly lower in rats that exercised and received LA than in the other groups. Compared with the other groups, rats that exercised and received LA had a significantly higher vitamin E concentration in the soleus. The SOD and GPx activities in the soleus and red gastrocnemius were significantly higher in rats that exercised and received LA. These results suggest that LA supplementation combined with aerobic treadmill exercise inhibits lipid peroxidation in skeletal muscles. This effect was especially remarkable in the soleus, which is particularly sensitive to oxidative stress, as revealed by the increased vitamin E level and SOD and GPx activities. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19083438/The_combination_of_alpha_lipoic_acid_supplementation_and_aerobic_exercise_inhibits_lipid_peroxidation_in_rat_skeletal_muscles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(08)00038-9 DB - PRIME DP - Unbound Medicine ER -