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Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples.
J Chromatogr A. 2009 Jan 09; 1216(2):205-10.JC

Abstract

A fast and novel sample preparation procedure for the determination of triclosan (TCS) and methyltriclosan (MTCS) in water samples is presented. Dispersive liquid-liquid microextraction, using a ternary mixture consisting of a disperser, an extractant and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) as derivatization reagent, was used for the simultaneous derivatization, case of TCS, and concentration of both species in different water samples. Analytes were determined by gas chromatography with tandem mass spectrometry (GC-MS/MS). Influence of different factors on the performance of the sample preparation process is thoroughly discussed. Under final working conditions, a mixture of 1 mL of methanol, 40 microL of 1,1,1-trichloroethane and the same volume of MTBSTFA was added to 10 mL of water in a conical bottom glass tube. After centrifugation, the settled phase was injected directly in the chromatographic system. TCS was quantitatively extracted and converted into the corresponding tert-butyldimethylsilyl derivative, whereas for MTCS an extraction yield around 90% was attained. Limits of quantification between 2 and 5 ng L(-1) and reproducibility values below 10% were achieved; moreover, the performance of the extraction process was scarcely affected by the type of water sample. Globally, these values are comparable, or even better, to those reported for other approaches applied to the determination of same compounds, with the advantage of a shorter sample preparation step. Analysis of surface and wastewater samples confirmed the ubiquitous presence of TCS in the aquatic environment at levels from 20 to 700 ng L(-1).

Authors+Show Affiliations

Departamento de Química Analítica, Nutrición y Bromatología, Instituto de Investigación y Análisis Alimentario, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19084234

Citation

Montes, R, et al. "Dispersive Liquid-liquid Microextraction Applied to the Simultaneous Derivatization and Concentration of Triclosan and Methyltriclosan in Water Samples." Journal of Chromatography. A, vol. 1216, no. 2, 2009, pp. 205-10.
Montes R, Rodríguez I, Rubí E, et al. Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples. J Chromatogr A. 2009;1216(2):205-10.
Montes, R., Rodríguez, I., Rubí, E., & Cela, R. (2009). Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples. Journal of Chromatography. A, 1216(2), 205-10. https://doi.org/10.1016/j.chroma.2008.11.068
Montes R, et al. Dispersive Liquid-liquid Microextraction Applied to the Simultaneous Derivatization and Concentration of Triclosan and Methyltriclosan in Water Samples. J Chromatogr A. 2009 Jan 9;1216(2):205-10. PubMed PMID: 19084234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples. AU - Montes,R, AU - Rodríguez,I, AU - Rubí,E, AU - Cela,R, Y1 - 2008/11/30/ PY - 2008/10/16/received PY - 2008/11/21/revised PY - 2008/11/25/accepted PY - 2008/12/17/entrez PY - 2008/12/17/pubmed PY - 2009/3/20/medline SP - 205 EP - 10 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1216 IS - 2 N2 - A fast and novel sample preparation procedure for the determination of triclosan (TCS) and methyltriclosan (MTCS) in water samples is presented. Dispersive liquid-liquid microextraction, using a ternary mixture consisting of a disperser, an extractant and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) as derivatization reagent, was used for the simultaneous derivatization, case of TCS, and concentration of both species in different water samples. Analytes were determined by gas chromatography with tandem mass spectrometry (GC-MS/MS). Influence of different factors on the performance of the sample preparation process is thoroughly discussed. Under final working conditions, a mixture of 1 mL of methanol, 40 microL of 1,1,1-trichloroethane and the same volume of MTBSTFA was added to 10 mL of water in a conical bottom glass tube. After centrifugation, the settled phase was injected directly in the chromatographic system. TCS was quantitatively extracted and converted into the corresponding tert-butyldimethylsilyl derivative, whereas for MTCS an extraction yield around 90% was attained. Limits of quantification between 2 and 5 ng L(-1) and reproducibility values below 10% were achieved; moreover, the performance of the extraction process was scarcely affected by the type of water sample. Globally, these values are comparable, or even better, to those reported for other approaches applied to the determination of same compounds, with the advantage of a shorter sample preparation step. Analysis of surface and wastewater samples confirmed the ubiquitous presence of TCS in the aquatic environment at levels from 20 to 700 ng L(-1). SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/19084234/Dispersive_liquid_liquid_microextraction_applied_to_the_simultaneous_derivatization_and_concentration_of_triclosan_and_methyltriclosan_in_water_samples_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(08)02115-8 DB - PRIME DP - Unbound Medicine ER -