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Commonalities in the genetics of Alzheimer's disease and Parkinson's disease.
Expert Rev Neurother 2008; 8(12):1865-77ER

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative diseases that have a tremendous impact on the lives of affected individuals. There is a great probability of developing concurrent parkinsonism in AD and vice versa than would be predicted by independent prevalence of each disease. Both diseases have genetic familial forms with a prevalence of less than 5-10%, but the majority of the cases are sporadic. Several hypotheses exist regarding the etiology of these diseases, such as oxidative stress, inflammatory processes, ubiquitin-proteasome system dysfunction, energy deficits, cell cycle deficiencies and glutamate exitotoxicities. Since diagnosis occurs in late-stage disease after neuronal loss, it decreases the opportunity for neuroprotective/neurorestorative therapies. Therefore, early and specific diagnosis is required as well as new therapy approaches for the growing burden of AD and PD.

Authors+Show Affiliations

University of Würzburg, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, Neurochemistry Laboratory, Füchsleinstr. 15, D-97080 Würzburg, Germany. gruenblatt_e@klinik.uni-wuerzburg.de

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19086884

Citation

Grünblatt, Edna. "Commonalities in the Genetics of Alzheimer's Disease and Parkinson's Disease." Expert Review of Neurotherapeutics, vol. 8, no. 12, 2008, pp. 1865-77.
Grünblatt E. Commonalities in the genetics of Alzheimer's disease and Parkinson's disease. Expert Rev Neurother. 2008;8(12):1865-77.
Grünblatt, E. (2008). Commonalities in the genetics of Alzheimer's disease and Parkinson's disease. Expert Review of Neurotherapeutics, 8(12), pp. 1865-77. doi:10.1586/14737175.8.12.1865.
Grünblatt E. Commonalities in the Genetics of Alzheimer's Disease and Parkinson's Disease. Expert Rev Neurother. 2008;8(12):1865-77. PubMed PMID: 19086884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Commonalities in the genetics of Alzheimer's disease and Parkinson's disease. A1 - Grünblatt,Edna, PY - 2008/12/18/entrez PY - 2008/12/18/pubmed PY - 2009/3/4/medline SP - 1865 EP - 77 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 8 IS - 12 N2 - Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative diseases that have a tremendous impact on the lives of affected individuals. There is a great probability of developing concurrent parkinsonism in AD and vice versa than would be predicted by independent prevalence of each disease. Both diseases have genetic familial forms with a prevalence of less than 5-10%, but the majority of the cases are sporadic. Several hypotheses exist regarding the etiology of these diseases, such as oxidative stress, inflammatory processes, ubiquitin-proteasome system dysfunction, energy deficits, cell cycle deficiencies and glutamate exitotoxicities. Since diagnosis occurs in late-stage disease after neuronal loss, it decreases the opportunity for neuroprotective/neurorestorative therapies. Therefore, early and specific diagnosis is required as well as new therapy approaches for the growing burden of AD and PD. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/19086884/Commonalities_in_the_genetics_of_Alzheimer's_disease_and_Parkinson's_disease_ L2 - http://www.tandfonline.com/doi/full/10.1586/14737175.8.12.1865 DB - PRIME DP - Unbound Medicine ER -