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Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis.
Am J Clin Nutr 2009; 89(2):568-76AJ

Abstract

BACKGROUND

Habitual consumption of diets with a high glycemic index (GI) and a high glycemic load (GL) may influence cancer risk via hyperinsulinemia and the insulin-like growth factor axis.

OBJECTIVE

The objective was to conduct a systematic review to assess the association between GI, GL, and risk of digestive tract cancers.

DESIGN

Medline and Embase were searched for relevant publications from inception to July 2008. When possible, adjusted results from a comparison of cancer risk of the highest compared with the lowest category of GI and GL intake were combined by using random-effects meta-analyses.

RESULTS

Cohort and case-control studies that examined the risk between GI or GL intake and colorectal cancer (n = 12) and adenomas (n = 2), pancreatic cancer (n = 6), gastric cancer (n = 2), and squamous-cell esophageal carcinoma (n = 1) were retrieved. Most case-control studies observed positive associations between GI and GL intake and these cancers. However, pooled cohort study results showed no associations between colorectal cancer risk and GI intake [relative risk (RR): 1.04; 95% CI: 0.92, 1.12; n = 7 studies] or GL intake (RR: 1.06; 95% CI: 0.95, 1.17; n = 8 studies). Furthermore, no significant associations were observed in meta-analyses of cohort study results of colorectal cancer subsites and GI and GL intake. Similarly, no significant associations emerged between pancreatic cancer risk and GI intake (RR: 0.99; 95% CI: 0.83, 1.19; n = 5 studies) or GL intake (RR: 1.01; 95% CI: 0.86, 1.19; n = 6 studies) in combined cohort studies.

CONCLUSIONS

The findings from our meta-analyses indicate that GI and GL intakes are not associated with risk of colorectal or pancreatic cancers. There were insufficient data available regarding other digestive tract cancers to make any conclusions about GI or GL intake and risk.

Authors+Show Affiliations

Cancer Epidemiology & Prevention Research Group, Centre for Clinical & Population Sciences, Queen's University Belfast, Mulhouse Building, Royal Victoria Hospital Site, Belfast, Northern Ireland. hmulholland04@qub.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

19088152

Citation

Mulholland, Helen G., et al. "Glycemic Index, Glycemic Load, and Risk of Digestive Tract Neoplasms: a Systematic Review and Meta-analysis." The American Journal of Clinical Nutrition, vol. 89, no. 2, 2009, pp. 568-76.
Mulholland HG, Murray LJ, Cardwell CR, et al. Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis. Am J Clin Nutr. 2009;89(2):568-76.
Mulholland, H. G., Murray, L. J., Cardwell, C. R., & Cantwell, M. M. (2009). Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis. The American Journal of Clinical Nutrition, 89(2), pp. 568-76. doi:10.3945/ajcn.2008.26823.
Mulholland HG, et al. Glycemic Index, Glycemic Load, and Risk of Digestive Tract Neoplasms: a Systematic Review and Meta-analysis. Am J Clin Nutr. 2009;89(2):568-76. PubMed PMID: 19088152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis. AU - Mulholland,Helen G, AU - Murray,Liam J, AU - Cardwell,Chris R, AU - Cantwell,Marie M, Y1 - 2008/12/16/ PY - 2008/12/18/entrez PY - 2008/12/18/pubmed PY - 2009/2/12/medline SP - 568 EP - 76 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 89 IS - 2 N2 - BACKGROUND: Habitual consumption of diets with a high glycemic index (GI) and a high glycemic load (GL) may influence cancer risk via hyperinsulinemia and the insulin-like growth factor axis. OBJECTIVE: The objective was to conduct a systematic review to assess the association between GI, GL, and risk of digestive tract cancers. DESIGN: Medline and Embase were searched for relevant publications from inception to July 2008. When possible, adjusted results from a comparison of cancer risk of the highest compared with the lowest category of GI and GL intake were combined by using random-effects meta-analyses. RESULTS: Cohort and case-control studies that examined the risk between GI or GL intake and colorectal cancer (n = 12) and adenomas (n = 2), pancreatic cancer (n = 6), gastric cancer (n = 2), and squamous-cell esophageal carcinoma (n = 1) were retrieved. Most case-control studies observed positive associations between GI and GL intake and these cancers. However, pooled cohort study results showed no associations between colorectal cancer risk and GI intake [relative risk (RR): 1.04; 95% CI: 0.92, 1.12; n = 7 studies] or GL intake (RR: 1.06; 95% CI: 0.95, 1.17; n = 8 studies). Furthermore, no significant associations were observed in meta-analyses of cohort study results of colorectal cancer subsites and GI and GL intake. Similarly, no significant associations emerged between pancreatic cancer risk and GI intake (RR: 0.99; 95% CI: 0.83, 1.19; n = 5 studies) or GL intake (RR: 1.01; 95% CI: 0.86, 1.19; n = 6 studies) in combined cohort studies. CONCLUSIONS: The findings from our meta-analyses indicate that GI and GL intakes are not associated with risk of colorectal or pancreatic cancers. There were insufficient data available regarding other digestive tract cancers to make any conclusions about GI or GL intake and risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19088152/Glycemic_index_glycemic_load_and_risk_of_digestive_tract_neoplasms:_a_systematic_review_and_meta_analysis_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2008.26823 DB - PRIME DP - Unbound Medicine ER -