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Immunosuppressive activity of the ethanol extract of Sedum sarmentosum and its fractions on specific antibody and cellular responses to ovalbumin in mice.
Chem Biodivers. 2008 Dec; 5(12):2699-709.CB

Abstract

The immunosuppressive activity of the ethanol extract of Sedum sarmentosum (EESS) and its fractions was studied with respect to specific antibody and cellular response to ovalbumin (OVA) in mice. ICR Mice were immunized subcutaneously with OVA on days 0 and 14. Beginning on the day of immunization, the mice were administered intraperitoneally (ip) with EESS and it fractions at a single dose of 0.25, 0.5, and 1.0 mg, and cyclosporin A at a single dose of 0.1 mg at intervals of 7 days. On day 28, splenocyte proliferation and specific antibody level in serum were measured. EESS significantly suppressed concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and OVA-induced splenocyte proliferation in the immunized mice in a dose-dependent manner. The OVA-specific serum IgG, IgG1, and IgG2b levels in the immunized mice were also markedly reduced by EESS. Among four fractions of EESS, the BuOH fraction consisting mainly of flavonoid glycosides showed the highest suppressive activity. The results suggest that EESS could suppress the cellular and humoral immune response in mice, and deserve further research to be developed as immunosuppressant.

Authors+Show Affiliations

College of Animal Sciences, Zhejiang University, Hangzhou, P. R. China.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19089828

Citation

Qin, Feng, and Hong-Xiang Sun. "Immunosuppressive Activity of the Ethanol Extract of Sedum Sarmentosum and Its Fractions On Specific Antibody and Cellular Responses to Ovalbumin in Mice." Chemistry & Biodiversity, vol. 5, no. 12, 2008, pp. 2699-709.
Qin F, Sun HX. Immunosuppressive activity of the ethanol extract of Sedum sarmentosum and its fractions on specific antibody and cellular responses to ovalbumin in mice. Chem Biodivers. 2008;5(12):2699-709.
Qin, F., & Sun, H. X. (2008). Immunosuppressive activity of the ethanol extract of Sedum sarmentosum and its fractions on specific antibody and cellular responses to ovalbumin in mice. Chemistry & Biodiversity, 5(12), 2699-709. https://doi.org/10.1002/cbdv.200890224
Qin F, Sun HX. Immunosuppressive Activity of the Ethanol Extract of Sedum Sarmentosum and Its Fractions On Specific Antibody and Cellular Responses to Ovalbumin in Mice. Chem Biodivers. 2008;5(12):2699-709. PubMed PMID: 19089828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunosuppressive activity of the ethanol extract of Sedum sarmentosum and its fractions on specific antibody and cellular responses to ovalbumin in mice. AU - Qin,Feng, AU - Sun,Hong-Xiang, PY - 2008/12/18/entrez PY - 2008/12/18/pubmed PY - 2009/2/12/medline SP - 2699 EP - 709 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 5 IS - 12 N2 - The immunosuppressive activity of the ethanol extract of Sedum sarmentosum (EESS) and its fractions was studied with respect to specific antibody and cellular response to ovalbumin (OVA) in mice. ICR Mice were immunized subcutaneously with OVA on days 0 and 14. Beginning on the day of immunization, the mice were administered intraperitoneally (ip) with EESS and it fractions at a single dose of 0.25, 0.5, and 1.0 mg, and cyclosporin A at a single dose of 0.1 mg at intervals of 7 days. On day 28, splenocyte proliferation and specific antibody level in serum were measured. EESS significantly suppressed concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and OVA-induced splenocyte proliferation in the immunized mice in a dose-dependent manner. The OVA-specific serum IgG, IgG1, and IgG2b levels in the immunized mice were also markedly reduced by EESS. Among four fractions of EESS, the BuOH fraction consisting mainly of flavonoid glycosides showed the highest suppressive activity. The results suggest that EESS could suppress the cellular and humoral immune response in mice, and deserve further research to be developed as immunosuppressant. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/19089828/Immunosuppressive_activity_of_the_ethanol_extract_of_Sedum_sarmentosum_and_its_fractions_on_specific_antibody_and_cellular_responses_to_ovalbumin_in_mice_ L2 - https://doi.org/10.1002/cbdv.200890224 DB - PRIME DP - Unbound Medicine ER -