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The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes.
Thyroid 2009; 19(2):143-8T

Abstract

BACKGROUND

The lymphoid tyrosine phosphatase (LYP) encoded by the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene is a strong inhibitor of T cells. The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD) and type I diabetes (T1D). The purpose of this study was to examine the joint association of this polymorphism with the co-occurrence of AITD and T1D.

METHODS

In this association study, 310 white subjects were genotyped for the C1858T polymorphism. The study population included 70 patients with both AITD and T1D (AITD+T1D), 70 patients with AITD only, 70 patients with T1D only, and 100 healthy controls. Patients with both AITD and T1D, and controls were also typed for HLA-DRB1. PTPN22 C1858T genotyping was performed by minisequencing. For HLA-DRB1 typing, polymerase chain reaction (PCR) sequence-specific oligonucleotide probes were used.

RESULTS

The PTPN22 1858 minor T-allele frequency was strongly increased in patients with AITD+T1D (23.6%) compared with controls (8.0%, pc<0.001), with patients with AITD only (8.6%, pc=0.006), or with T1D only (10.7%, pc=0.028). T-allele carriers were also more frequently present in the group with AITD+T1D versus controls (41.4% vs. 14.0%, OR=4.35, 95% CI=2.08-9.09), AITD (17.1%, OR=3.42, 95% CI=1.56-7.48), and T1D (21.4%, OR=2.59, 95% CI=1.23-5.45). Especially in subjects with Hashimoto's thyroiditis (HT)+T1D, T-allele carriers were mostly frequent (50% vs. 14%, OR=6.14, 95% CI=2.62-14.38, pc<0.001). Considering all included patients with AITD, T-allele carriers were 29.3% vs. 14.0% in controls (p=0.008, OR=2.54, 95% CI=1.30-4.98). Patients carrying the PTPN22 1858 T allele had a twofold increased frequency of the HLA-DRB1*03 allele (64.7% vs. 37.3%, pc=0.034).

CONCLUSION

The PTPN22 gene is a joint susceptibility locus for AITD (especially HT) and T1D.

Authors+Show Affiliations

Department of Medicine I, Gutenberg University, Mainz, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19090780

Citation

Dultz, Georg, et al. "The Protein Tyrosine Phosphatase Non-receptor Type 22 C1858T Polymorphism Is a Joint Susceptibility Locus for Immunthyroiditis and Autoimmune Diabetes." Thyroid : Official Journal of the American Thyroid Association, vol. 19, no. 2, 2009, pp. 143-8.
Dultz G, Matheis N, Dittmar M, et al. The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes. Thyroid. 2009;19(2):143-8.
Dultz, G., Matheis, N., Dittmar, M., Röhrig, B., Bender, K., & Kahaly, G. J. (2009). The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes. Thyroid : Official Journal of the American Thyroid Association, 19(2), pp. 143-8. doi:10.1089/thy.2008.0301.
Dultz G, et al. The Protein Tyrosine Phosphatase Non-receptor Type 22 C1858T Polymorphism Is a Joint Susceptibility Locus for Immunthyroiditis and Autoimmune Diabetes. Thyroid. 2009;19(2):143-8. PubMed PMID: 19090780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes. AU - Dultz,Georg, AU - Matheis,Nina, AU - Dittmar,Manuela, AU - Röhrig,Bernd, AU - Bender,Klaus, AU - Kahaly,George J, PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/4/3/medline SP - 143 EP - 8 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 19 IS - 2 N2 - BACKGROUND: The lymphoid tyrosine phosphatase (LYP) encoded by the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene is a strong inhibitor of T cells. The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD) and type I diabetes (T1D). The purpose of this study was to examine the joint association of this polymorphism with the co-occurrence of AITD and T1D. METHODS: In this association study, 310 white subjects were genotyped for the C1858T polymorphism. The study population included 70 patients with both AITD and T1D (AITD+T1D), 70 patients with AITD only, 70 patients with T1D only, and 100 healthy controls. Patients with both AITD and T1D, and controls were also typed for HLA-DRB1. PTPN22 C1858T genotyping was performed by minisequencing. For HLA-DRB1 typing, polymerase chain reaction (PCR) sequence-specific oligonucleotide probes were used. RESULTS: The PTPN22 1858 minor T-allele frequency was strongly increased in patients with AITD+T1D (23.6%) compared with controls (8.0%, pc<0.001), with patients with AITD only (8.6%, pc=0.006), or with T1D only (10.7%, pc=0.028). T-allele carriers were also more frequently present in the group with AITD+T1D versus controls (41.4% vs. 14.0%, OR=4.35, 95% CI=2.08-9.09), AITD (17.1%, OR=3.42, 95% CI=1.56-7.48), and T1D (21.4%, OR=2.59, 95% CI=1.23-5.45). Especially in subjects with Hashimoto's thyroiditis (HT)+T1D, T-allele carriers were mostly frequent (50% vs. 14%, OR=6.14, 95% CI=2.62-14.38, pc<0.001). Considering all included patients with AITD, T-allele carriers were 29.3% vs. 14.0% in controls (p=0.008, OR=2.54, 95% CI=1.30-4.98). Patients carrying the PTPN22 1858 T allele had a twofold increased frequency of the HLA-DRB1*03 allele (64.7% vs. 37.3%, pc=0.034). CONCLUSION: The PTPN22 gene is a joint susceptibility locus for AITD (especially HT) and T1D. SN - 1557-9077 UR - https://www.unboundmedicine.com/medline/citation/19090780/The_protein_tyrosine_phosphatase_non_receptor_type_22_C1858T_polymorphism_is_a_joint_susceptibility_locus_for_immunthyroiditis_and_autoimmune_diabetes_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2008.0301?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -