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Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study.
J Urol 2009; 181(2):710-6JU

Abstract

PURPOSE

We explored risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in the open population.

MATERIALS AND METHODS

A longitudinal, population based study with a followup of 6.5 years was done in 1,688 men who were 50 to 78 years old. Data were collected on transrectal ultrasound of prostate volume, urinary flow rate, ultrasound estimated post-void residual urine volume, generic and disease specific quality of life, and symptom severity based on the International Prostate Symptom Score. Lower urinary tract symptoms suggestive of benign prostatic hyperplasia were defined as an International Prostate Symptom Score of greater than 7 after a report of a score of less than 7 in the previous round. A multivariate Cox proportional hazard model was constructed to determine risk factors for clinical benign prostatic hyperplasia after correcting for patient age.

RESULTS

Total followup was 4,353 person-years. During followup 180 events of attaining an International Prostate Symptoms Score of greater than 7 occurred. Multivariate analysis showed that functional bladder capacity, post-void residual urine volume, treatment for cardiac diseases, education level, antidepressant use, calcium antagonist use, erectile function or dysfunction, prostate specific antigen and a family history of prostate cancer were determinants with a significant HR.

CONCLUSIONS

In addition to age, we established 9 significant determinants for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. However, not all risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia are accounted for since we can conclude that 1 of 3 men without these risk factors will still be diagnosed with lower urinary tract symptoms suggestive of benign prostatic hyperplasia between ages 50 and 80 years.

Authors+Show Affiliations

Department of Urology, University Medical Center Utrecht, Utrecht, The Netherlands. e.t.kok-2@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19091352

Citation

Kok, Esther Tanja, et al. "Risk Factors for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in a Community Based Population of Healthy Aging Men: the Krimpen Study." The Journal of Urology, vol. 181, no. 2, 2009, pp. 710-6.
Kok ET, Schouten BW, Bohnen AM, et al. Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study. J Urol. 2009;181(2):710-6.
Kok, E. T., Schouten, B. W., Bohnen, A. M., Groeneveld, F. P., Thomas, S., & Bosch, J. L. (2009). Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study. The Journal of Urology, 181(2), pp. 710-6. doi:10.1016/j.juro.2008.10.025.
Kok ET, et al. Risk Factors for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in a Community Based Population of Healthy Aging Men: the Krimpen Study. J Urol. 2009;181(2):710-6. PubMed PMID: 19091352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study. AU - Kok,Esther Tanja, AU - Schouten,Boris W, AU - Bohnen,Arthur M, AU - Groeneveld,Frans P M W, AU - Thomas,Siep, AU - Bosch,J L H Ruud, Y1 - 2008/12/16/ PY - 2008/06/09/received PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/2/5/medline SP - 710 EP - 6 JF - The Journal of urology JO - J. Urol. VL - 181 IS - 2 N2 - PURPOSE: We explored risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in the open population. MATERIALS AND METHODS: A longitudinal, population based study with a followup of 6.5 years was done in 1,688 men who were 50 to 78 years old. Data were collected on transrectal ultrasound of prostate volume, urinary flow rate, ultrasound estimated post-void residual urine volume, generic and disease specific quality of life, and symptom severity based on the International Prostate Symptom Score. Lower urinary tract symptoms suggestive of benign prostatic hyperplasia were defined as an International Prostate Symptom Score of greater than 7 after a report of a score of less than 7 in the previous round. A multivariate Cox proportional hazard model was constructed to determine risk factors for clinical benign prostatic hyperplasia after correcting for patient age. RESULTS: Total followup was 4,353 person-years. During followup 180 events of attaining an International Prostate Symptoms Score of greater than 7 occurred. Multivariate analysis showed that functional bladder capacity, post-void residual urine volume, treatment for cardiac diseases, education level, antidepressant use, calcium antagonist use, erectile function or dysfunction, prostate specific antigen and a family history of prostate cancer were determinants with a significant HR. CONCLUSIONS: In addition to age, we established 9 significant determinants for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. However, not all risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia are accounted for since we can conclude that 1 of 3 men without these risk factors will still be diagnosed with lower urinary tract symptoms suggestive of benign prostatic hyperplasia between ages 50 and 80 years. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/19091352/Risk_factors_for_lower_urinary_tract_symptoms_suggestive_of_benign_prostatic_hyperplasia_in_a_community_based_population_of_healthy_aging_men:_the_Krimpen_Study_ L2 - https://www.jurology.com/doi/full/10.1016/j.juro.2008.10.025?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -