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Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men.
Nutr Metab Cardiovasc Dis 2009; 19(6):401-8NM

Abstract

BACKGROUND AND AIMS

To determine whether triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), which has been shown to be an indicator of the metabolic syndrome (MetS) and insulin resistance, can predict coronary heart disease (CHD) independently of total cholesterol (TC) and other risk factors in an Iranian population with a high prevalence of MetS and low HDL-C.

METHODS AND RESULTS

Between February 1999 and August 2001, 1824 men > or =40 years old, free of clinical cardiovascular diseases at baseline, were followed. Baseline measurements included serum level of TC, HDL-C, TG and risk factors for CHD including age, systolic and diastolic blood pressure, body mass index, waist circumference, diabetes, smoking and a family history of premature cardiovascular diseases. During a median follow up of 6.5 years until March 2007 (11,316 person-years at risk), a total of 163 new CHD events (27 fatal and 136 nonfatal) occurred. The prevalence of MetS in subjects with TG/HDL-C > or =6.9 (top quartile) reached 63.6% versus 3.0% in those with TG/HDL-C <2.8 (low quartile). According to a stepwise Cox proportional hazard model, including TG and TG/HDL-C quartiles, with TC and other risk factors, men in the top quartile of TG/HDL-C relative to the first quartile had a significant hazard ratio (HR) of 1.75 (95% CI, 1.02-3.00), while TG did not remain in the model.

CONCLUSION

The evaluation of TG/HDL-C ratio should be considered for CHD risk prediction in our male population with a high prevalence of MetS.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C.), P.O. Box. Tehran 19395-4763, Iran. fzhadaegh@endocrine.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19091534

Citation

Hadaegh, F, et al. "Triglyceride/HDL-cholesterol Ratio Is an Independent Predictor for Coronary Heart Disease in a Population of Iranian Men." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 19, no. 6, 2009, pp. 401-8.
Hadaegh F, Khalili D, Ghasemi A, et al. Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men. Nutr Metab Cardiovasc Dis. 2009;19(6):401-8.
Hadaegh, F., Khalili, D., Ghasemi, A., Tohidi, M., Sheikholeslami, F., & Azizi, F. (2009). Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 19(6), pp. 401-8. doi:10.1016/j.numecd.2008.09.003.
Hadaegh F, et al. Triglyceride/HDL-cholesterol Ratio Is an Independent Predictor for Coronary Heart Disease in a Population of Iranian Men. Nutr Metab Cardiovasc Dis. 2009;19(6):401-8. PubMed PMID: 19091534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men. AU - Hadaegh,F, AU - Khalili,D, AU - Ghasemi,A, AU - Tohidi,M, AU - Sheikholeslami,F, AU - Azizi,F, Y1 - 2008/12/16/ PY - 2008/06/02/received PY - 2008/08/24/revised PY - 2008/09/05/accepted PY - 2008/12/19/entrez PY - 2008/12/19/pubmed PY - 2009/9/9/medline SP - 401 EP - 8 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 19 IS - 6 N2 - BACKGROUND AND AIMS: To determine whether triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C), which has been shown to be an indicator of the metabolic syndrome (MetS) and insulin resistance, can predict coronary heart disease (CHD) independently of total cholesterol (TC) and other risk factors in an Iranian population with a high prevalence of MetS and low HDL-C. METHODS AND RESULTS: Between February 1999 and August 2001, 1824 men > or =40 years old, free of clinical cardiovascular diseases at baseline, were followed. Baseline measurements included serum level of TC, HDL-C, TG and risk factors for CHD including age, systolic and diastolic blood pressure, body mass index, waist circumference, diabetes, smoking and a family history of premature cardiovascular diseases. During a median follow up of 6.5 years until March 2007 (11,316 person-years at risk), a total of 163 new CHD events (27 fatal and 136 nonfatal) occurred. The prevalence of MetS in subjects with TG/HDL-C > or =6.9 (top quartile) reached 63.6% versus 3.0% in those with TG/HDL-C <2.8 (low quartile). According to a stepwise Cox proportional hazard model, including TG and TG/HDL-C quartiles, with TC and other risk factors, men in the top quartile of TG/HDL-C relative to the first quartile had a significant hazard ratio (HR) of 1.75 (95% CI, 1.02-3.00), while TG did not remain in the model. CONCLUSION: The evaluation of TG/HDL-C ratio should be considered for CHD risk prediction in our male population with a high prevalence of MetS. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19091534/Triglyceride/HDL_cholesterol_ratio_is_an_independent_predictor_for_coronary_heart_disease_in_a_population_of_Iranian_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(08)00187-7 DB - PRIME DP - Unbound Medicine ER -